Enzyme reactivator treatment in organophosphate exposure: Clinical relevance of thiocholinesteratic activity of pralidoxime

Journal of Applied Toxicology

Volumn 24, Issue 6, 2004, Pages 429-435

  Petroianu, Georg A ^a,b   Missler, Anke ^a   Zuleger, Katia ^a   Thyes, Caroline ^a   Ewald, Vanessa ^a   Maleck, Wolfgang H ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^c Spital Grenchen   (Switzerland)

Author keywords

Cholinesterase; Organophosphate; Poisoning; Pralidoxime; Therapy

Indexed keywords

ACETYLTHIOCHOLINE; BUTYRYLTHIOCHOLINE; CHOLINESTERASE; ENZYME ACTIVATOR; ORGANOPHOSPHATE; PRALIDOXIME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVITY; EXPERIMENTAL ANIMAL; FEMALE; INTOXICATION; MINIPIG; NONHUMAN; PHOTOMETRY; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANIMALS; ANTIDOTES; CHOLINESTERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; PHOTOMETRY; POISONING; PRALIDOXIME COMPOUNDS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SWINE;

EID: 9644270247     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.995     Document Type: Article

References (23)

1. Bergner AD, O'Neill JJ. 1958. A modification of the Koelle technique for use with oximes. J. Histochem. Cytochem. 6: 72-74.
2. Dart RC, Goldfrank LR, Chyka PA, Lotzer D, Woolf AD, McNally J, Snodgrass WR, Olson KR, Scharman E, Geller RJ, Spyker D, Kraft M, Lipsy R. 2000. Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States. Ann. Emerg. Med. 36: 126-132.
3. Ellman GL, Courtney KD, Andres V, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholin-esterase activity. Biochem Pharmacol 7: 88-95.
4. Geldmacher-von Mallinckrodt M, Urbach HJ, Kittel H, Lindorf HH. 1969. Zur Messung der in vivo und in vitro Reaktivierbarkeit alkylphosphatvergifteter Serumcholinesterase durch 2-PAM und Toxogonin mit verschiedenen Substanzen. Z. Klin. Chem. Klin. Bioochem. 7: 480-485.
5. Heitmann R, Felgenhauer K. 1969. On the esterolytic effect of toxogonin. Dtsch. Med. Wochenschr. 94: 1583.
6. Jeyaratnam J. 1990. Acute pesticide poisoning: a major global health problem. World Health Stat. Q. 43: 139-144.
7. Johnson MK, Jacobsen D, Meredith TJ, Eyer P, Heath AJ, Ligtenstein DA, Marrs TC, Szinicz L, Vale JA and Haines JA. 2000. Evaluation of antidotes for poisoning by organophosphorus pesticides. Emerg. Med. 12: 22-37.
8. Karalliedde L. 1999. Organophosphorus poisoning and anaesthesia. Anaesthesia 54: 1073-1088.
9. Levine R. 1991. Recognized and possible effects of pesticides in humans. In Handbook of Pesticide Toxiclogy, General Principles Vol. 1, Hayes WJ, Laws ER (eds). Academic Press: San Diego; 275-360.
10. Maleck WH, Kern N, Beha U, Roth C, Rufer R, Petroianu GA. 2002. iv-L-lactate application in minipigs partially protects acetylcholinesteratic, but not butyrylcholinesteratic activity in plasma from inhibition by paraoxon. Crit. Care Med. 30: 1547-1552.
11. Martindale. 1999. The Complete Drug Reference (32nd edn), Parfitt K (ed.). Pharmaceutical Press: Taunton, MA; 992-993.
12. Namba T. 1971. Cholinesterase inhibition by organophosporus compounds, and its clinical effects. Bull. WHO 44: 289-307.
13. Namba T, CT Nolle, J Jackrel, D Grob. 1971. Poisoning due to organophosphate insecticides: acute and chronic manifestations. Am. J. Med. 50: 475-492.
14. Nenner M, Erdmann WD. 1969. Toxogonin - a catalyst of ester hydrolysis? Ger. Med. Mon. 14: 194-196.
15. Pannbacker RG, Oehme FW. 2003. Pralidoxime hydrolysis of thiocholine esters. Vet Hum. Toxicol. 45: 39-40.
16. Peter JV, AM. Cherian. 2000. Organic insecticides. Anaesth. Intens. Care 28: 11-21.
17. Petroianu G., L. M. Toomes, A. Petroianu, W. Bergeler, R. Rüfer. 1998a. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs. J. Appl. Toxicol. 18: 293-298.
18. Petroianu G, Altmannsberger S, Maleck W, Jatzko A, Bergler W, Ruefer R. 1998b. Zero stress anaesthesia induction (ZESTRANI) in Göttingen minipigs. Scand. J. Lab. Anim. Sci. 25 (Suppl. 1): 109-115.
19. Petroianu G, Roth C, Beha U, Fischer J, Bergler W, Rüfer R. 2001. Pralidoxime and L-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: pralidoxime does not confer superior protection. J. Appl. Toxicol. 21: 7-13.
20. Sidell FR, WA Groff, A Kaminskis. 1972. Pralidoxime methanesulfonate, plasma levels and pharmacokinetics after oral administration to man. J. Pharm. Sci. 61: 1136-1140.
21. Swartz RD, Sidell FR. 1973. Effects of heart and exercise on the elimination of pralidoxime in man. Clin. Pharmacol. Ther. 14: 83-89.
22. van Helden HP, Busker RW, Melchers BPC, Bruijnzeel PLB. 1996. Pharmacological effects of oximes: how relevant are they? Arch. Toxicol. 70: 779-786.
23. Zoch E. 1971. Die Wirkung organischer Phosphorsäureester bzw. Phosphorsäureester auf verschiedene Enzyme. Arzneim. Forschung. 21: 181-187.