Pralidoxime and l-lactate effects in vitro on the inhibition of acetylcholinesterase by paraoxon: Pralidoxime does not confer superior protection

Journal of Applied Toxicology

Volumn 21, Issue 1, 2001, Pages 7-13

  Petroianu, Georg ^a   Roth, Christina ^a   Beha, Ulrike ^a   Fisher, Joseph ^a   Bergler, Wolfgang ^a   Rüfer, Roderich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Acetylcholinesterase; In vitro; l lactate; Organophosphorus compounds; Paraoxon; Pralidoxime

Indexed keywords

BUTYRYLCHOLINE; CHOLINESTERASE INHIBITOR; LACTIC ACID; ORGANOPHOSPHORUS COMPOUND; PARAOXON; PRALIDOXIME;

ARTICLE; BLOOD SAMPLING; CATECHOLAMINE RELEASE; CELL PROTECTION; CHEMICAL WARFARE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; INTOXICATION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; DRUG INTERACTIONS; FEMALE; HUMANS; LACTIC ACID; MALE; PARAOXON; PRALIDOXIME COMPOUNDS;

EID: 0035131921     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.726     Document Type: Article

References (10)

1. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis
2. Organophosphorus poisoning and anaesthesia
3. Recognized and possible effects of pesticides in humans
4. Nerve gases
5. Die Wirkung organischer Phosphorsäureester bzw. Phosphorsäureester auf verschiedene Enzyme
6. Cholinesterase inhibition by organophosphorous compounds and its clinical effects
7. Control of blood pressure, heart rate and haematocrit during high-dose intravenous paraoxon exposure in mini pigs
8. Pharmacological effects of oximes: How relevant are they?
9. L-lactate reduces in vitro the inhibition of butyrylcholinesterase (BChE) by paraoxon (E 600)
10. L-Lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600)