Potassium chloride supplementation diminishes platelet reactivity in humans

Hypertension

Volumn 44, Issue 6, 2004, Pages 969-973

  Kimura, Masayuki ^a   Lu, Xiaobin ^a   Skurnick, Joan ^b   Awad, Girgis ^a   Bogden, John ^b   Kemp, Francis ^b   Aviv, Abraham ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

Atherosclerosis; Cardiovascular disease; Stroke

Indexed keywords

ADENOSINE DIPHOSPHATE; POTASSIUM CHLORIDE;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POTASSIUM EXCRETION; POTASSIUM INTAKE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; ADULT; BLOOD PRESSURE; COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION; POTASSIUM; POTASSIUM CHLORIDE; SODIUM;

EID: 9644258507     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000147660.58694.6f     Document Type: Article

References (22)

1. Gallen IW, Rosa RM, Esparaz DY, Young JB, Robertson GL, Battle D, Epstein FH, Landsberg L. On the mechanism of the effects of potassium restriction on blood pressure and renal sodium retention. Am J Kidney Dis. 1998;31:19-27.
2. Whelton PK, He J, Cutler JA, Brancati FL, Appel LJ, Follmann D, Kleg. MJ Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. J Am Med Assoc. 1997;277:1624-1632.
3. Suter PM. The effects of potassium, magnesium, calcium, and fiber on risk of stroke. Nutr Rev. 1999;57:84-88.
4. Ascherio A, Rimm EB, Hernan MA, Giovannucci EL, Kawachi I, Stampfer MJ, Willett WC. Intake of potassium, magnesium, calcium and fiber and risk of stroke among US men. Circulation. 1998;98:1198-1204.
5. Iso H, Stampfer MJ, Manson JE, Rexrode K, Hennekeus CH, Colditz GA, Speizer FC, Willette WC. Prospective study of calcium, potassium and magnesium intake and risk of stroke in women. Stroke. 1999;30:772-1779.
6. Green DM, Ropper AH, Kronmal RA, Psaty BM, Burke GL. Cardiovascular Health Study: serum potassium level and dietary potassium intake as risk factors for stroke. Neurology. 2002;59:314-320.
7. Khaw KT, Barrett-Connor E. Dietary potassium and stroke-associated mortality. A 12-year prospective population study. N Engl J Med. 1987;316:235-240.
8. Franse LV, Pahor M, Di Bari M, Somes GW, Cushman WC, Applegate WB. Hypokalemia associated with diuretic use and cardiovascular events in the Systolic Hypertension in the Elderly Program. Hypertension. 2000;35:10250-11030.
9. Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective mechanisms. Am J Physiol. 1995;268:R825-R837.
10. Sica DA, Struthers AD, Cushman WC, Wood M, Banas JS Jr, Epstein M. Importance of potassium in cardiovascular disease. J Clin Hypertens. 2002;4:198-206.
11. Luft FC, Rankin LI, Bloch R, Weyman AE, Willis LR, Murray RH, Grim CE, Weinberger MH. Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men. Circulation. 1979;60:697-706.
12. Watson RL, Langford HG, Abernethy J, Barnes TY, Watson MJ. Urinary electrolytes, body weight, and blood pressure. Pooled cross-sectional results among four groups of adolescent females. Hypertension. 1980;2:93-98.
13. Pratt JH, Jones JJ, Miller JZ, Wagner MA, Fineberg NS. Racial differences in aldosterone excretion and plasma aldosterone concentrations in children. N Engl J Med. 1989;321:1152-1157.
14. Langford HG, Cushman WC, Hsu H. Chronic effect of K Cl on black-white differences in plasma renin activity, aldosterone, and urinary electrolytes. Am J Hypertens. 1991;4:399-403.
15. Pratt JH, Ambrosius WT, Agarwal R, Eckert GJ, Newman S. Racial difference in the acticity of the amiloride-sensitive epithelial sodium channel. Hypertension. 2002;40:903-908.
16. Aviv A, Hollenberg NK, Weder A. Urinary potassium excretion and sodium sensitivity in blacks. Hypertension. 2004;43:707-713.
17. Kimura M, Jeanclos EM, Donnelly RJ, Lytton J, Reeves JP, Aviv A. Physiological and molecular characterization of the Na+/Ca2+ exchanger in human platelets. Am J Physiol. 1999;277:H911-H917.
18. Kimura M, Aviv A, Reeves JP. K(+)-dependent Na+/Ca2+ exchange in human platelets. J Biol Chem. 1993;268:6874-6877.
19. Lin H, Young DB. Thrombosis/thrombolysis/vasodilator responses: interaction between plasma potassium and epinephrine in coronary thrombosis in dogs. Circulation 1994;89:331-338.
20. Huo Y, Schober A, Forlow SB, Smith DF, Hyman MC, Jung S, Littman DR, Weber C, Ley K. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med. 2003;9:61-67.
21. Haszon I, Papp F, Kovacs J, Haszon T, Papp F, Kovacs J, Bors M, Nemeth T, Bereczki C, Turi S. Platelet aggregation, blood viscosity and serum lipids in hypertensive and obese children. Eur J Pediatr. 2003;162:385-390.
22. Preston RA, Jy W, Jimenez JJ, Mauro LM, Horstman LL, Valle M, Aime G, Ahn YS. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension. 2003;41:211-217.