Fischer 344 rats display age-related memory deficits in trace fear conditioning

Behavioral Neuroscience

Volumn 118, Issue 6, 2004, Pages 1166-1175

  Villarreal, Julissa S ^a   Dykes, James R ^a   Barea Rodriguez, Edwin J ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN FUNCTION; CONDITIONING; CONTROLLED STUDY; FEAR; FREEZING; HIPPOCAMPUS; MOTOR DYSFUNCTION; NONHUMAN; PROCESS DEVELOPMENT; RAT; SENSORY DYSFUNCTION; TASK PERFORMANCE; TRAINING;

AGE FACTORS; AGING; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING (PSYCHOLOGY); FEAR; IMMOBILIZATION; MALE; MEMORY DISORDERS; RATS; RATS, INBRED F344; TIME FACTORS;

EID: 9644253002     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.118.6.1166     Document Type: Article

References (29)

1. Barnes, C. A. (1987). Neurological and behavioral investigations of memory failure in aging animals. International Journal of Neurology, 21-22, 130-136.
2. Barnes, C. A., Nadel, L., & Honig, W. K. (1980). Spatial memory deficit in senescent rats. Canadian Journal of Psychology, 34, 29-39.
3. Blank, T., Nijholt, I., Kye, M. J., Radulovic, J., & Spiess, J. (2003). Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits. Nature Neuroscience, 6, 911-912.
4. Clayton, D. A., Mesches, M. H., Alvarez, E., Bickford, P. C., & Browning, M. D. (2002). A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. Journal of Neuroscience, 22, 3628-3637.
5. Gallagher, M., Burwell, R., & Burchinal, M. (1993). Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze. Behavioral Neuroscience, 107, 618-626.
6. Houston, F. P., Stevenson, G. D., McNaughton, B. L., & Barnes, C. A. (1999). Effects of age on the generalization and incubation of memory in the F344 rat. Learning & Memory, 6, 111-119.
7. Huerta, P. T., Sun, L. D., Wilson, M. A., & Tonegawa, S. (2000). Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons. Neuron, 25, 473-480.
8. Kim, J. J., & Fanselow, M. S. (1992, May 1). Modality-specific retrograde amnesia of fear. Science, 256, 675-677.
9. Kirk, R. E. (1995). Experimental design: Procedures for the behavioral sciences. Pacific Grove, CA: Brooks/Cole.
10. Knuttinen, M. G., Gamelli, A. E., Weiss, C., Power, J. M., & Disterhoft, J. F. (2001). Age-related effects on eyeblink conditioning in the F344 × BN F1 hybrid rat. Neurobiology of Aging, 22, 1-8.
11. Maren, S. (1998). Overtraining does not mitigate contextual fear conditioning deficits produced by neurotoxic lesions of the basolateral amygdala. Journal of Neuroscience, 18, 3088-3097.
12. McEchron, M. D., Bouwmeester, H., Tseng, W., Weiss, C., & Disterhoft, J. F. (1998). Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat. Hippocampus, 8, 638-646.
13. McEchron, M. D., & Disterhoft, J. F. (1997). Sequence of single neuron changes in CA1 hippocampus of rabbits during acquisition of trace eyeblink conditioned responses. Journal of Neurophysiology, 78, 1030-1044.
14. Morris, R. G., Garrud, P., Rawlins, J. N., & O'Keefe, J. (1982, June 24). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
15. Moser, M. B., Moser, E. I., Forrest, E., Andersen, P., & Morris, R. G. (1995). Spatial learning with a minislab in the dorsal hippocampus. Proceedings of the National Academy of Sciences, USA, 92, 9697-9701.
16. Moyer, J. R., Jr., Deyo, R. A., & Disterhoft, J. F. (1990). Hippocampectomy disrupts trace eye-blink conditioning in rabbits. Behavioral Neuroscience, 104, 243-252.
17. Moyer, J. R., Jr., Thompson, L. T., & Disterhoft, J. F. (1996). Trace eyeblink conditioning increases CA1 excitability in a transient and learning-specific manner. Journal of Neuroscience, 16, 5536-5546.
18. Oler, J. A., & Markus, E. J. (1998). Age-related deficits on the radial maze and in fear conditioning: Hippocampal processing and consolidation. Hippocampus, 8, 402-415.
19. Phillips, R. G., & LeDoux, J. E. (1992). Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience, 106, 274-285.
20. Rawlins, J. N. (1985). Associations across time: The hippocampus as a temporary memory store. Behavioral and Brain Neuroscience, 8, 479-528.
21. Rudy, J. W., & Sutherland, R. J. (1989). The hippocampal formation is necessary for rats to learn and remember configural discriminations. Behavioural Brain Research, 34, 97-109.
22. Rudy, J. W., & Sutherland, R. J. (1995). Configural association theory and the hippocampal formation: An appraisal and reconfiguration. Hippocampus, 5, 375-389.
23. Scoville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery, and Psychiatry, 20, 11-21.
24. Thompson, L. T., Moyer, J. R., Jr., & Disterhoft, J. F. (1996). Transient changes in excitability of rabbit CA3 neurons with a time course appropriate to support memory consolidation. Journal of Neurophysiology, 76, 1836-1849.
25. Villarreal, J. S., Gonzalez-Lima, F., Berndt, J., & Barea-Rodriguez, E. J. (2002). Water maze training in aged rats: Effects on brain metabolic capacity and behavior. Brain Research, 939, 43-51.
26. Wallenstein, G. V., Eichenbaum, H., & Hasselmo, M. E. (1998). The hippocampus as an associator of discontiguous events. Trends in Neurosciences, 21, 317-323.
27. Weeber, E. J., Atkins, C. M., Selcher, J. C., Varga, A. W., Mirnikjoo, B., Paylor, R., et al. (2000). A role for the beta isoform of protein kinase C in fear conditioning. Journal of Neuroscience, 20, 5906-5914.
28. Weiss, C., Bouwmeester, H., Power, J. M., & Disterhoft, J. F. (1999). Hippocampal lesions prevent trace eyeblink conditioning in the freely moving rat. Behavioural Brain Research, 99, 123-132.
29. Weitemier, A. Z., & Ryabinin, A. E. (2003). Alcohol-induced memory impairment in trace fear conditioning: A hippocampus-specific effect. Hippocampus, 13, 305-315.