Age-related deficits on the radial maze and in fear conditioning: Hippocampal processing and consolidation

Hippocampus

Volumn 8, Issue 4, 1998, Pages 402-415

  Oler, Jonathan A ^a   Markus, Etan J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Aging; Massed conditioning; Rats; Spaced conditioning; Spatial learning; Working memory

Indexed keywords

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; CONDITIONING; CONTROLLED STUDY; FEAR; HIPPOCAMPUS; INFORMATION PROCESSING; LEARNING; MALE; MAZE TEST; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; RAT; WORKING MEMORY;

AGING; ANIMALS; CONDITIONING (PSYCHOLOGY); FEAR; HIPPOCAMPUS; MALE; MAZE LEARNING; RATS; RATS, INBRED F344; RETENTION (PSYCHOLOGY); TIME FACTORS;

EID: 0031683583     PISSN: 10509631     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1063(1998)8:4<402::AID-HIPO8>3.0.CO;2-I     Document Type: Article

References (74)

1. Amaral DG, Witter MP. The three-dimensional organization of the hippocampal formation: a review of anatomical data Neuroscience 1989;31:571-591.
2. Ando S, Ohashi Y. Longitudinal study on age-related changes of working and reference memory in the rat Neurosci Lett 1991;128:17-20.
3. Barnes C. Spatial cognition and functional alterations of aged rat hippocampus. In: Wang E, Snyder DS, eds. Handbook of the aging brain. New York: Academic Press, 1998.
4. Barnes CA, McNaughton BL. An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses. Behav Neurosci 1985;99:1040-1048.
5. Barnes CA, Nadel L, Honig WK. Spatial memory deficit in senescent rats. Can J Psychol 1980;34:29-39.
6. BartusRT, Dean RL, Fleming DL. Aging in the mesus monkey: effects on visual discrimination learning and reversal learning. J Gerontol 1979;34:209-219.
7. Birren JE. Age differences in learning a two-choice task water maze by rats. J Gerontol 1962;17:207-213.
8. Blanchard RJ, Fukunaga KK, Blanchard DC. Environmental control and defensive reactions to foot shock. Bull Psychonomic Soc 1976;8:129-130.
9. Belles RC. Species-specific defensive reactions and avoidance learning. Psychol Rev 1970;71:32-48.
10. Botwinick J, Brinley JF, Robbin JS. Learning a position discrimination and position reversals by Sprague-Dawley rats of different ages. J Gerontol 1962;17:315-319.
11. Brown JE, Hunt K, Markus EJ. Fear conditioning the relative importance of local and distal spatial contextual environment. Soc Neurosci Abstr 1997;23:1609.
12. Bruner CA, Vargas I. The activity of rats in a swimming situation as a function of water temperature. Physiol Behav 1994;55:21-28.
13. Bruning RH, Holzbauer E, Kimberlin C. Age, word imagery and delay interval: effects on short-term and long-term retention. J Gerontol 1975;30:312-318.
14. Buzsáki G. The hippocampal-neocortical dialogue. Cereb Cortex 1996;6: 81-92.
15. D'Amato MR. Experimental Psychology: Methodology, Psychophysics, and Learning. New York: McGraw-Hill.
16. Davis M. The role of the amygdala in fear and anxiety. Annu Rev Neurosci 1992;15:353-375.
17. Desmond NL, Levy WB. Ovarian steroidal control of connectivity in the female hippocampus: an overview of recent experimental findings and speculations on its functional consequences. Hippocampus 1997;7: 239-245.
18. Dudchenko PA, Goodridge JP, Seiterle DA, Taube JS. Effects of repeated disorientation on acquisition of spatial tasks in rats: dissociation between the appetitive radial arm maze and aversive water maze. J Exp Psychol 1997;23:194-210.
19. Ebbinghaus H. Memory: A Contribution to Experimental Psychology. New York: Dover.
20. Eichenbaum H, Otto T, Cohen NJ. Two functional components of the hippocampal memory system. Behav Brain Sci 1994;17:449-518.
21. Fanselow MS, DeCola JP, Young SL. Mechanisms responsible for reduced contextual conditioning with massed unsignaled unconditional stimuli. J Exp Psychol Anim Behav Process 1993;19:121-137.
22. Fischer W, Chen KS, Gage FH, Bjorklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol Aging 1992;13:9-23.
23. Fisk AD, Hertzog C, Lee MD, Rogers WA, Anderson Garlach M. Long-term retention of skilled visual search: do young adults retain more than old adults? Psychol Aging 1994;9:206-215.
24. Frohman LA. A neuroendocrine overview of aging. Neurobiol Aging 1994;15:479-484.
25. Gallagher M, Burwell RD. Relationship of age-related decline across several behavioral domains. Neurobiol Aging 1989;10:691-708.
26. Gallagher M, Rapp PR. The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 1997;48:339-370.
27. Geinisman Y, Bondareff W, Dodge JT. Partial deafferentation of neurons in the dentate gyrus of the senescent rat. Brain Res 1977;134:541-545.
28. Geinisman Y, deToledo-Morrell L, Morrell F, Heller RE. Hippocampal markers of age-related memory dysfunction: behavioral, electrophysiological and morphological perspectives. Prog Neurobiol 1995;45:223-252.
29. Goodrick CL. Learning, retention, and extinction of a complex maze habit for mature-young and sensecent Wistar albino rats. J Gerontol 1968;23:298-304.
30. Hodges H. Maze procedures: the radial-arm maze and water maze compared. Brain Res Cogn Brain Res 1996;3:167-181.
31. Houston FP, Stevenson GD, McNaughton BL, Barnes CL. Faster forgetting of spatial context and altered consolidation dynamics in aged F344 rats. Soc Neurosci Abstr 1997;23:507.
32. Jarrard LE. On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 1993;60:9-26.
33. Kadar T, Silbermann M, Brandeis R, Levy A. Age-related structural changes in the rat hippocampus: correlation with working memory deficiency. Brain Res 1990;512:113-120.
34. Kay H, Sime ME. Discrimination learning with old and young rats. J Gerontol 1962;17:75-80.
35. Kim JJ, Fanselow MS. Modality-specific retrograde amnesia of fear. Science 1992;256:675-677.
36. Lindner MD, Gribkoff VK. Relationship between performance in the Morris water task, visual acuity, and thermoregulatory function in aged F-344. Behav Brain Res 1991;45:45-55.
37. Markowska AL, Stone WS, Ingram DK, Reynolds J, Gold PE, Conti LH, Pontecorvo MJ, Wenk GL, Olton DS. Individual differences in aging behavioral and neurobiological correlates. Neurobiol Aging 1989;10: 31-43.
38. Markus EJ, Zecevic M. Sex differences and estrous cycle changes in hippocampus-dependent fear conditioning. Psychobiology 1997;25: 246-252.
39. Martin GM, Harley CW, Smith AR, Hoyles ES, Hynes CA. Spatial disorientation blocks reliable goal location on a plus maze but does not prevent goal location in the water maze. J Exp Psychol 1997;23: 183-193.
40. McClelland JL, O'Reilly R, McNaughton BL. Why are there complementary learning systems in the hippocampus and neocortex: insights from successes and failures of connectionist models of learning and memory. Psychol Rev 1995;102:419-457.
41. Miller RA. The aging immune system: primer and prospectus. Science 1996;273:70-74.
42. Morris RGM. Development of the water-maze procedure for studying learning in the rat. J Neurosci 1984;11:47-60.
43. Norris CM, Korol DL, Foster TC. Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging. J Neurosci 1996;16:5382-5392.
44. Oler JA, Markus EJ. Aging and the hippocampus: impairments on fear conditioning and radial maze tasks. Soc Neurosci Abstr 1997;23: 1608.
45. Olton DS, Samuelson RJ. Remembrance of places passed spatial memory in rats. J Exp Psychol Anim Behav Process 1976;2:97-116.
46. O'Steen WK, Spencer RL, Bare DJ, McEwen BS. Analysis of severe photoreceptor loss and Morris water-maze performance in aged rats. Behav Brain Res 1995;68:151-158.
47. Pelleymounter MA, Smith MY, Gallagher M. Spatial learning impairments in aged rats trained with a salient configuration of stimuli. Psychobiology 1987;15:248-254.
48. Petit TL, Markus EJ. The cellular basis of learning and memory: the anatomical sequel to neuronal use. In: Milgram N, Macleod C, Petit T, eds. Neural plasticity, learning and memory. New York: Academic Press, 1987;87-124.
49. Phillips RG, LeDoux JE. Lesions in the dorsal hippocampus formation interfere with background but not foreground contextual fear conditioning. Learn Mem 1994;1:34-44.
50. Phillips RG, LeDoux LE. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning Behav Neurosci 1992;106:274-285.
51. Port RL, Murphy HA, Magee RA. Age-related impairment in instrumental conditioning is restricted to initial acquisition. Exp Aging Res 1996;22:73-81.
52. QinY, McNaughton BL, Skaggs WE, Barnes CA, Suster MS, Weaver KL, Gerrard JL. Interaction between hippocampus and neocortex in the replay of temporal sequences during sleep. Soc Neurosci Abstr 1996;22:1872.
53. Rick JT, Murphy MP, Ivy GO, Milgram NW. Short intertriai intervals impair water maze performance in old Fischer 344 rats. J Gerontol Biol Sci 1996;51A:B253-B260.
54. Rozenzweig MR, Bennett EL, Colombo PJ, Lee DW, Serrano PA. Short-term, intermediate-term, and long-term memories. Behav Brain Res 1993;57:193-198.
55. Sarter M, Markowitsch HJ. Reduced resistance to progressive extinction in senescent rats: a neuroanatomical and behavioral study. Neurobiol Aging 1983;4:203-215.
56. Schneider-Rivas S, Rivas-Arancibia S, Vazquez-Pereyra F, Vazquez-Sandoval R, Borgonio-Perez G. Modulation of long-term memory and extinction responses induced by growth hormone (gh) and growth hormone releasing hormone (ghrh) in rats. Life Sci 1995;56: PL433-441.
57. Scoville WB, Milner B. Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 1957;20:11-21.
58. Shinowara NL, London ED, Rapoport SI. Changes in retinal morphology and glucose utilization in aging albino rats. Exp Eye Res 1982;34:517-530.
59. Skaggs WE, McNaughton BL. Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science 1996;271:1870-1873.
60. Solyom L, Miller S. The effect of age differences on the acquisition of operant and classical conditioned responses in rats. J Gerontol 1965;20:311-314.
61. Squire LR. The hippocampus, space, and human amnesia. Behav Brain Sci 1979;2:241-273.
62. Squire LR. Memory and the hippocampus: a synthesis from findings with rats, monkeys and humans, Psychol Rev 1992;99:195-231.
63. Stephens DN, Weidmann R, Quartermain D, Sarter M. Reversal learning in senescent rats. Behav Brain Res 1985;17:193-202.
64. Stewart J, Mitchell J, Kalant N. The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and the Morris water mazes. Neurobiol Aging 1989;10:669-675.
65. Stoehr JD, Wenk GL. Effects of age and lesions of the nucleus basalis on contextual fear conditioning. Psychobiology 1995;23:173-177.
66. Underwood BJ. Ten years of massed practice on distributed practice. Psychol Rev 1961;68:229-247.
67. Wallace JE, Krauter EE, Campbell BA. Animal models of declining memory in the aged: short-term and spatial memory in the aged rat J Gerontol 1980;35:355-363.
68. Willig F, Palacios A, Monmaur P, M'harzi M, Laurent J, Delacour J. Short-term memory, exploration and locomotor activity in aged rats. Neurobiol Aging 1987;8:393-402.
69. Winocur G. The effects of retroactive and proactive interference on learning and memory in young and old rats. Dev Psychobiol 1984;17:537-545.
70. Winocur G. Long-term memory loss in senescent rats neuropsychological analysis of interference and context effects. Psychol Aging 1988;3:273-279.
71. Woodruff-Pak DS. Aging and classical conditioning: parallel studies in rabbits and humans. Neurobiol Aging 1988;9:511-522.
72. Woolley CL, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuations in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci 1990;10:4035-4039.
73. Woolley CS, McEwen BS. Estradiol mediates fluctuations in hippocampal synaptic density during the estrous cycle in the adult rat. J Neurosci 1992;12:2549-2554.
74. Zyzak DR, Otto T, Eichenbaum H, Gallagher M. Cognitive decline associated with normal aging in rats: a neuropsychological approach. Learn Mem 1995;2:1-16.