Targeting malaria with polyamines

Bioconjugate Chemistry

Volumn 15, Issue 6, 2004, Pages 1161-1165

  Geall, Andrew J ^a   Baugh, John A ^b   Loyevsky, Mark ^c   Gordeuk, Victor R ^c   Al Abed, Yousef ^d   Bucala, Richard ^e  

^a VICAL INC   (United States)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c HOWARD UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d North Shore LIJ Research Institute ^*  (United States)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; BLOOD; DISEASES; ENZYME ACTIVITY; FLUORESCENCE;

EXTRACELLULAR; FLUORESCENT MICROSCOPY; HUMAN ERYTHROCYTES; INTRACELLULAR ACCUMULATION; PARASITE-; PLASMODIUM FALCIPARUM; POLYAMINE CONJUGATES; POLYAMINES; SPERMIDINE; SYNTHESISED;

AMINES;

ANTHRANILIC ACID DERIVATIVE; N METHYLANTHRANILIC ACID; POLYAMINE; PUTRESCINE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

ASEXUAL REPRODUCTION; CONFERENCE PAPER; CONTROLLED STUDY; ERYTHROCYTE; FLUORESCENCE; HUMAN; HUMAN CELL; MALARIA; METABOLISM; NONHUMAN; PARASITE DEVELOPMENT; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 9244257354     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0499578     Document Type: Conference Paper

References (22)

1. Tabor, C. W., and Tabor, H. (1984) Polyamines. Annu. Rev. Biochem. 53, 749-790.
2. Kramer, D. L, Miller, J. T., Bergeron, R. J., Khomutov, R., Knomutov, A., and Porter, C. W. (1993) regulation of polyamine transport by polyamines and polyamine analogs. J. Cell Physiol. 155, 399-407.
3. Marton, L. J., and Pegg, A. E. (1995) Polyamines as targets for therapeutic intervention. Annu. Rev. Pharmacol. Toxicol. 35, 55-91.
4. Seiler, N., Delcros, J. G., and Moulinoux, J. P. (1996) Review: Polyamine transport in mammalian cells. Int. J. Biochem. Cell Biol. 28, 843-861.
5. Assaraf, Y. G., Golenser, J., Spira, D. T., and Bachrach, U. (1984) Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malaria parasite, Plasmodium falciparum. Biochem. J. 222, 815-819.
6. Müller, S., Coombs, G. H., and Walter, R. D. (2001) Targeting polyamines of parasitic protozoa in chemotherapy. Trends Parasitol. 17, 242-249.
7. Moulinoux, J.-P., Le Calve, M., Quemener, V., and Quash, G. (1984) In vitro studies on the entry of polyamines into normal red blood cells. Biochimie 66, 385-393.
8. Singh, S., Puri, S. K., Singh, S. K., Srivastava, R., Gupta, R. C., and Pandey, V. C. (1997) Characterization of simian malarial parasite (Plasmodium. falciparum)-induced putrescine transport in rhesus monkey erythroctes. J. Biol. Chem. 272, 13506-13511.
9. Muller, S., Da'dara, A., Luersen, K., Wrenger, C., Das Gupta, R., Madhubala, R., and Walter, R. D. (2000) In the human malaria parasite Plasmodium falciparum, polyamines are synthesized by a bifunctional ornithine decarboxylase, s-adenosylmethionine decarboxylase. J. Biol. Chem. 11, 8097-8102.
10. Le Roch, K. G., Zhou, Y., Blair, P. L., Grainger, M., Moch, J. K., Haynes, J. D., De La Vega, P., Holder, A. A., Batalov, S., Carucci, D. J., and Winzeler, E. A. (2003) Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 301, 1503-1508.
11. Kaiser, A., Gottwald, A., Maier, W. and Seitz, H. M. (2003) Targeting enzymes involved in spermidine metabolism of parasitic protozoa - a possible new strategy for anti-parasitic treatment. Parasitol. Res. 91, 508-516.
12. Ginsburg, H., and Kirk, K. (1998) Membrane Transport in the Malaria-infected Erythrocyte. Malaria: Parasite Biology, Pathogenesis, and Protection (Sherman, I. W., Ed.) pp 219-232, ASM Press, Washington, DC.
13. Cullis, P. M., Green, R. E., Merson-Davies, L., and Travis, N. (1999) Probing the mechanism of transport and compartmentalization of polyamines in mammalian cells. Chem. Biol. 6, 717-729.
14. Porter, C. W., Miller, J., and Bergeron, R. J. (1984) Aliphatic chain-length specificity of the polyamine transport-system in ascites L1210 leukemia-cells. Cancer Res. 44, 126-128.
15. Bergeron, R. J., McManis, J. S., Weimar, W. R., Schreier, K. M., Gao, F., Wu, Q., Oritiz-Ocasio, J., Luchetta, G. R., Porter, C., and Vinson, J. R. T. (1995) The role of charge in polyamine analogue recognition. J. Med. Chem. 38, 2278-2285.
16. Wang, C., Delcros, J.-G., Cannon, L., Konate, F., Carias, H., Biggerstaff, J., Gardner, R. A., and Phanstiel, O., IV. (2003) Defining the molecular requirements for selective delivery of polyamine conjugates into cells containing active polyamine transporters. J. Med. Chem. 46, 5129-5138.
17. Aziz, S. M., Yatin, M., Worthen, D. R., Lipke, D. W., and Crooks, P. A. (1998) A novel technique for visualizing the intracellular localization and distribution of transported polyamines in cultured pulmonary artery smooth muscle cells. J. Pharm. Biomed. Anal. 17, 307-320.
18. Ganem, B., and Chantrapromma, K. (1983) Preparation of thermospermine. Methods Enzymol. 94, 416-418.
19. Lurdes, M., Almeida, S., Grehn, L., and Ragnarsson, U. (1988) Selective protection of polyamines: Synthesis of model compounds and spermidine derivatives. J. Chem. Soc., Perkin Trans, 1 1905-1911.
20. + + 1 = 279.
21. a studies and condensation of calf thymus DNA. Bioconjugate Chem. 11, 314-326.
22. Geall, A. J., and Blagbrough, I. S. (2000) Homologation of polyamines in the rapid synthesis of lipospermine conjugates and related lipoplexes. Tetrahedron 56, 2449-2460.