Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: Requirement of upstream sequences for control by the proximal regulatory domain

Endocrinology

Volumn 137, Issue 3, 1996, Pages 1080-1088

  Frenkel, B ^a   Montecino, M ^a   Green, J ^a   Aslam, F ^a   Desai, R ^a   Banerjee, C ^a   Stein, J L ^a   Lian, J B ^a   Stein, G S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; OSTEOCALCIN; TRANSCRIPTION FACTOR; VITAMIN D;

ARTICLE; CELL DIFFERENTIATION; CHROMATIN STRUCTURE; DNA TRANSFECTION; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; REGULATOR GENE; REPORTER GENE; TRANSCRIPTION REGULATION; VITAMIN METABOLISM;

EID: 0030053230     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.3.8603577     Document Type: Article

References (42)

1. Stein GS, Lian JB 1995 Molecular mechanisms mediating proliferation-differentiation interrelationships during progressive development of the osteoblast phenotype: update 1995. Endocr Rev 4:290-297
2. Kesterson RA, Stanley L, DeMayo F, Finegold M, Pike JW 1993 The human osteocalcin promoter directs bone-specific vitamin D-regulatable gene expression in transgenic mice. Mol Endocrinol 7:462-467
3. Baker AR, Hollingshead PG, Pitts-Meek S, Hansen S, Taylor R, Stewart TA 1992 Osteoblast-specific expression of growth hormone stimulates bone growth in transgenic mice. Mol Cell Biol 12:5541-5547
4. Aslam F, Shalhoub V, van Wijnen AJ, Banerjee C, Bortell R, Shakoori AR, Litwack G, Stein JL, Stein GS, Lian JB 1995 Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription. Mol Endocrinol 9:679-690
5. Banerjee C, Hiebert SW, Stein JL, Lian JB, Stein GS, An AML-1 consensus sequence binds an osteoblast-specific complex and transcriptionally activates the osteocalcin gene. Proc Natl Acad Sci USA, in press.
6. 3. Proc Natl Acad Sci USA 87:369-373
7. Ducy P, Karsenty G 1995 Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene. Mol Cell Biol 15:1858-1869
8. Frenkel B, Mijnes J, Aronow MA, Zambetti G, Banerjee C, Stein JL, Lian JB, Stein GS 1993 Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene. Biochemistry 32:13636-13643
9. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL 1994 Transcriptional control of the tissue-specific developmentally regulated osteocalcin gene requires a binding motif for the MSX-family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-42891
10. 3. Proc Natl Acad Sci USA 86:4455-4459
11. 3-mediated transcriptional activation. Mol Endocrinol 5:373-385
12. Towler DA, Bennett CD, Rodan GA 1994 Activity of the rat osteocalcin basal promoter in osteoblastic cells is dependent upon homeodomain and CP1 binding motifs. Mol Endocrinol 8:614-624
13. 3. Biochemistry 17:8521-8526
14. Frenkel B, Montecino M, Stein JL, Lian JB, Stein GS 1994 A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene; promoter and cell type requirements. Proc Natl Acad Sci USA 91:10923-10927
15. Heinrichs AAJ, Banerjee C, Bortell R, Owen TA, Stein JL, Stein GS, Lian JB 1993 Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation. J Cell Biochem 53:240-250
16. Tamura M, Noda M 1994 Identification of a DNA sequence involved in osteoblast-specific gene expression via interaction with helix-loop-helix (HLH)-type transcription factors. J Cell Biol 126:773-782
17. Lian J, Stewart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Zambetti G, Stein G 1989 Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Proc Natl Acad Sci USA 86:1143-1147
18. Hoffmann HM, Beumer T, Rahman S, McCabe LR, Banerjee C, Aslam F, Tiro JA, van Wijnen AJ, Stein JL, Stein GS, Lian JB Bone tissue specific transcription of the osteocalcin gene: role of an activator osteoblast specific complex and suppressor Hox proteins that bind the OC box. J Cell Biochem, in press
19. Bortell R, Owen TA, Bidwell JP Gavazzo P, Breen E, van Wijnen AJ, DeLuca HF, Stein JL, Lian JB, Stein GS 1992 Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression. Proc Natl Acad Sci USA 89:6119-6123
20. Bidwell JP, van Wijnen AJ, Fey EG, Dworetzky S, Penman S, Stein JL, Lian JB, Stein GS 1993 Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proc Natl Acad Sci USA 90:3162-3166
21. Montecino M, Pockwinse S, Lian J, Stein G, Stein J 1994 DNase I hypersensitive sites in promoter elements associated with basal and vitamin D dependent transcription of the bone-specific osteocalcin gene. Biochemistry 33:348-353
22. Felsenfeld G 1992 Chromatin as an essential part of the transcriptional mechanism. Nature 355:219-224
23. Pienta KJ, Getzenberg RH, Coffey DS 1991 Cell structure and DNA organization. Eukary Gene Expr 1:355-385
24. Stein GS, van Wijnen AJ, Stein J, Lian B, Montecino M 1995 Contribution of nuclear architecture to transcriptional control. Int Rev Cytol 162A:251-278
25. Elgin SCR 1988 The formation and function of DNase I hypersensitive sites in the process of gene activation. J Biol Chem 263:19259-19262
26. Schild C, Claret F-X, Wahli W, Wolffe AP 1993 A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro. EMBO J 12:423-433
27. Baniahmad A, Ha I, Reinberg D, Tsai S, Tsai MJ, O'Malley BW 1993 Interaction of human thyroid hormone receptor β with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc Natl Acad Sci USA 90:8832-8836
28. Ing NH, Beekman JM, Tsai SY, Tsai MJ, O'Malley BW 1992 Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J Biol Chem 267:17617-17623
29. Blanco JCG, Wang I-M, Tsai SY, Tsai M-J, O'Malley BW, Jurutka PW, Haussler MR, Ozato K 1995 Transcription factor TFIIB and the vitamin D receptor cooperatively activate ligand-dependent transcription. Proc Natl Acad Sci USA 92:1535-1539
30. MacDonald PN, Sherman DR, Dowd DR, Jefcoat Jr SC, DeLisle RK 1995 The vitamin D receptor interacts with general transcription factor IIB. J Biol Chem 270:4748-4752
31. Majeska RJ, Rodan SB, Rodan GA 1980 Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology 107:1494-1503
32. Ausubel FM, Brent R, Kingston R, Moore DD, Seidman JG, Smith JA, Struhl K (eds) 1989 Current Protocols in Molecular Biology. Wiley and Sons, New York
33. Chen CA, Okayama H 1987 High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7:2745-2752
34. Gundberg CM, Hauschka P, Lian JB, Gallop PM 1984 Osteocalcin: isolation characterization and detection. In: Moldave K (ed) Methods in Enzymology. Academic Press, New York, vol 107:516-544
35. Wu C 1980 The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I. Nature 286:854-860
36. Bortell R, Owen TA, Shalhoub V, Heinrichs A, Aronow MA, Rochette-Egly C, Lutz Y, Stein JL, Lian JB, Stein GS 1993 Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein/DNA interactions at promoter regulatory elements. Proc Natl Acad Sci USA 90:2300-2304
37. Thompson JF, Hayes LS, Lloyd DB 1991 Modulation of firefly luciferase stability and impact on studies of gene regulation. Gene 103:171-177
38. Breen EC, van Wijnen AJ, Lian JB, Stein GS, Stein JL 1994 In vivo occupancy of the vitamin D responsive element in the osteocalcin gene supports vitamin D dependent transcriptional upregulation in intact cells. Proc Natl Acad Sci USA 91:12902-12906
39. Markose ER, Stein JL, Stein GS, Lian JB 1990 Vitamin D-mediated modifications in protein-DNA interactions at two promoter elements of the osteocalcin gene. Proc Natl Acad Sci USA 87:1701-1705
40. Merriman HL, van Wijnen AJ, Hibert S, Bidwell JP, Fey E, Lian B, Stein J, Stein GS 1995 The tissue-specific nuclear matrix protein, NMP-2, is a member of the AML/CBF/PEBP2 runt domain transcription factor family: interactions with the osteocalcin promoter. Biochemistry 34:13125-13132
41. van den Ent FMI, van Wijnen AJ, Last TJ, Bortell R, Stein JL, Lian JB, Stein GS 1993 Concerted control of multiple histone promoter factors during cell density inhibition of proliferation in osteosarcoma cells: reciprocal regulation of cell cycle controlled and bone-related genes. Cancer Res 53:2399-2409
42. Gorman CM, Moffat LF, Howard BH 1982 Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol 2:1044-1051