The influence of autoantibodies to myeloperoxidase on neutrophil function and intracellular signaling

Japanese Journal of Infectious Diseases

Volumn 57, Issue 5, 2004, Pages

  Williams, Julie ^a   Hewins, Peter ^a   Savage, Caroline ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BETA2 INTEGRIN; CALCIUM; CD11B ANTIGEN; CD18 ANTIGEN; CYTOKINE; FC RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C BETA; PROTEIN KINASE SYK; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; THROMBOXANE; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN ANTIBODY REACTION; APOPTOSIS; CALCIUM TRANSPORT; CELL ADHESION; CELL SURFACE; CONFERENCE PAPER; CYTOKINE RELEASE; DEGRANULATION; DISEASE ASSOCIATION; ENZYME ACTIVITY; HUMAN; LEUKOCYTE FUNCTION; PATHOGENESIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; RESPIRATORY BURST; SIGNAL TRANSDUCTION; SMALL VESSEL VASCULITIS; SYSTEMIC VASCULITIS;

ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; HUMANS; NEUTROPHILS; PEROXIDASE; SIGNAL TRANSDUCTION; VASCULITIS;

EID: 9144269698     PISSN: 13446304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (8)

1. Hewins, P. and Savage, C. O. S. (2002): Anti-neutrophil cytoplasm antibody associated vasculitis. Int. J. Biochem. Cell. Biol., 1347, 1-6.
2. Harper, L., Williams, J. M. and Savage, C. O. S. (2004): The importance of resolution of inflammation in the pathogenesis of ANCA-associated vasculitis. Biochem. Soc. Trans., 32, 502-506.
3. Hewins, P., Williams, J. M., Wakelam, M. J. O. and Savage, C. O. S. (2004): Activation of Syk in neutrophils by anti-neutrophil cytoplasm antibodies occurs via Fcγ receptors and CD18. J. Am. Soc. Nephrol., 15, 796-808.
4. Kettritz, R., Choi., M., Rolle, S., Wellner, M. and Luft, F. (2004): Integrins and cytokines activate nuclear transcription factor-kappab in human neutrophils. J. Biol. Chem., 279, 2657-2665.
5. Calderwood, J., Williams, J., Morgan, M., Nash, G. and Savage, C. (2004): ANCA induces β2 integrin and CXC chemokine dependent neutrophil-endothelial cell interactions that mimic those of highly cytokine activated endothelium. J. Leukoc. Biol., (in press).
6. Williams, J. M., Ben-Smith, A., Hewins, P.,Dove, S. K., Hughes, P., McEwan, R. et al. (2003): Activation of the Gi heterotrimeric G protein by ANCA IgG F(ab')2 fragments is necessary but not sufficient to stimulate the recruitment of those downstream mediators used by intact ANCA IgG. J. Am. Soc. Nephrol., 14, 661-669.
7. Williams, J. and Savage, C. (2004): Characterisation of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. J. Am. Soc. Nephrol., (in press).
8. Hattar, K. Bickenbach, A., Csernok, E., Rosseau, S., Grandel, U., Seeger, W. et al. (2002): Antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release-role of autocrine activation. J. Leukoc. Biol., 71, 996-1004.