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9144253823
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note
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Typical loadings are 0.0125 mmol of 1 and 0.0112 mmol of 2 per gram of SBA-15, respectively.
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18
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9144231148
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note
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Although β-alkyl β-ketoesters can be hydrogenated with complete conversions in the presence of 1% of 2, much inferior e.e. values (10-15% lower) were obtained.
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19
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33845282793
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21
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9144262901
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note
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All the reactions were judged to have > 99% conversions based on integrations of NMR peaks. E.e.% values were determined by GC using a Superco γ-Dex 225 column or by HPLC using a Chiralpak AD column and by SFC using a Chiralpak AS column.
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