Purification, Molecular Cloning, and Expression of a Novel Growth-Promoting Factor for Retinal Pigment Epithelial Cells, REF-1/TFPI-2

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 1, 2004, Pages 245-252

  Tanaka, Yasuhiko ^a   Utsumi, Jun ^b   Matsui, Mizuo ^c   Sudo, Tetsuo ^b   Nakamura, Noriko ^b   Mutoh, Masato ^b   Kajita, Akemi ^b   Sone, Saburo ^b   Kigasawa, Kazuteru ^d   Shibuya, Masahiko ^a   Reddy, Venkat N ^e   Zhang, Qiang ^a,f   Iwata, Takeshi ^a  

^a NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

^c NIHON UNIVERSITY   (Japan)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e UNIVERSITY OF MICHIGAN   (United States)

^f KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; GROWTH FACTOR; PLACENTA PROTEIN 5; RECOMBINANT PROTEIN; RETINA PIGMENT EPITHELIUM CELL FACTOR 1; SERINE PROTEINASE INHIBITOR; TISSUE FACTOR PATHWAY INHIBITOR; TISSUE FACTOR PATHWAY INHIBITOR 1; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CHO CELL; CHROMATOGRAPHY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; EXPRESSION VECTOR; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN UMBILICAL VEIN ENDOTHELIUM CELL; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; PIGMENT EPITHELIUM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; RETINA PIGMENT EPITHELIUM K1034 CELL;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; CELL LINE; CHO CELLS; CLONING, MOLECULAR; CRICETINAE; CULTURE MEDIA, CONDITIONED; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLASTS; GENE EXPRESSION; GENETIC VECTORS; GLYCOPROTEINS; GROWTH SUBSTANCES; HUMANS; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; PIGMENT EPITHELIUM OF EYE; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE PROTEINASE INHIBITORS; TRANSFECTION;

EID: 9144260699     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0230     Document Type: Article

References (26)

1. Marmor MF. Introduction to structure, function, and diseases of the retinal pigment epithelium. In: Marmor MF, Wolfensberger TJ. The Retinal Pigment Epithelium: Function and Disease. London, UK: Oxford University Press. 1998;3-12.
2. Hackett SF, Schoenfeld CL, Freund J, Gottsch JD, Bhargave S, Campochiaro PA. Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells. Exp Eye Res. 1997;64:865-873.
3. Campochiaro PA, Glaser BM. Platelet-derived growth factor is chemotactic for human retinal pigment epithelial cells. Arch Ophthalmol. 1985;103:576-579.
4. Kaven CW, Spraul CW, Zavazava NK, Lang GK, Lang GE. Growth factor combinations modulate human retinal pigment epithelial cell proliferation. Curr Eye Res. 2000;20:480-487.
5. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC, Gospodarowicz D. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature. 1987;325:257-259.
6. Cassidy L, Barry P, Shaw C, Duffy J, Kennedy S. Platelet derived growth factor and fibroblast growth factor basic levels in the vitreous of patients with vitreoretinal disorders. Br J Ophthalmol. 1998;82:181-185.
7. Kliffen M, Sharma HS, Mooy CM, Kerkvliet S, de Jong PT. Increased expression of angiogenic growth factors in age-related maculopathy. Br J Ophthalmol. 1997;81:154-162.
8. Sprecher CA, Kisiel W, Mathewes S, Foster DC. Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. Proc Natl Acad USA. 1994;91:3353-3357.
9. Miyagi Y, Koshikawa N, Yasumitsu H, et al. cDNA cloning and mRNA expression of a serine proteinase inhibitor secreted by cancer cells: identification as placental protein 5 and tissue factor pathway inhibitor-2. J Biochem. 1994;116:939-942.
10. Utsumi J, Iizuka M, Kobayashi S. Interferon production with multitray culture system on a large scale. J Interferon Res. 1984;4:9-16.
11. Kigasawa K, Soushi S, Tanaka Y, Obazawa H. Morphologic and chromosomal study of a human retinal pigment epithelial cell line. Jpn J Ophthalmol. 1994;38:10-15.
12. Sano E, Okano K, Sawada R, et al. Constitutive long-term production and characterization of recombinant human interferon-gammas from two different mammalian cells. Cell Struct Funct. 1988;13:143-159.
13. Petersen LC, Sprecher CA, Foster DC, Blumberg H, Hamamoto T, Kisiel W. Inhibitory properties of a novel human Kunitz-type protease inhibitor homologous to tissue factor pathway inhibitor, Biochemistry. 1996;35:266-272.
14. Rao CN, Reddy P, Liu Y, et al. Extracellular matrix-associated serine protease inhibitors (Mr. 33, 000, 31.000, and 27, 000) are single-gene products with differential glycosylation: cDNA cloning of the 33-kDa inhibitor reveals its identity to tissue factor pathway inhibitor-2. Arch Biochem Biophys. 1996;335:82-92.
15. Rao CN, Mohanam S, Puppala A, Rao JS. Regulation of proMMP-1 and ProMMP-3 activation by tissue factor pathway inhibitor-2/matrix-associated serine protease inhibitor. Biochem Biophys Res Commun. 1999;255:94-98.
16. Herman MP, Sukhova GK, Kiesiel W, et al. Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implication for atherosclerosis. J Clin Invest. 2000;107:1117-1126.
17. Shinoda E, Yui Y, Hattori R, et al. Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells. J Biol Chem. 1999;274:5379-5384.
18. Konduri SD, Tasiou A, Chandrasekar N, Nicolson GL, Rao JS. Role of tissue factor pathway inhibitor-2 (TFPI-2) in amelanotic melanoma (C-32) invasion. Clin Exp Metastasis. 2000;18:303-308.
19. Konuri SD, Rao CN, Chandrasekar N, et al. A novel function of tissue factor pathway inhibitor-2 (TFPI-2) in human glioma invasion. Oncogene. 2001;20:6938-6945.
20. Ortego J, Escribano J, Coca-Prados M. Gene expression of proteases and protease inhibitors in the human ciliary epithelium and ODM-2 cells. Exp Eye Res. 1997;65:289-299.
21. Lee SC, Seong GJ, Kim SH, Kwon OW. Synthesized TGF-beta s in RPE regulates cellular proliferation. Kor J Ophthalmol. 1999;13:16-24.
22. Gasson JC, Molecular physiology of granulocyte-macrophages colony stimulating factors. Blood. 1991;77:1131-1145.
23. Fischer HG, Frosch S, Reske K, Reske-Kunz AB. Granulocyte-macrophages colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation. J Immunol. 1988;141:3882-3888.
24. Crane IJ, Kuppner MC, McKillop-Smith S, Wallace CA, Forrester JV. Cytokine regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) production by human retinal pigment epithelial cells. Clin Exp Immunol. 1999;115:288-293.
25. Plank SR, Huang X-N, Robertson JE, Rosenbaum JT. Retinal pigment epithelial cells produce interleukin-1β and granulocyte-macrophage colony-stimulating factor in response to interleukin-1α. Curr Eye Res. 1993;12:205-212.
26. Crane IJ, Wallace CA, Forrester JV. Regulation of granulocyte-macrophage colony-stimulating factor in human retinal pigment epithelial cells by IL-1β and IFN-γ. Cell Immunol. 2001;209:132-139.