Orally Administered Targeted Recombinant Beta-Lactamase Prevents Ampicillin-Induced Selective Pressure on the Gut Microbiota: A Novel Approach to Reducing Antimicrobial Resistance

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 1, 2004, Pages 75-79

  Harmoinen, Jaana ^a   Mentula, Silja ^b   Heikkilä, Matti ^a   Van Der Rest, Michel ^e   Rajala Schultz, Päivi J ^f   Donskey, Curtis J ^g   Frias, Rafael ^a   Koski, Pertti ^c   Wickstrand, Nina ^c   Jousimies Somer, Hannele ^b   Westermarck, Elias ^a   Lindevall, Kai ^d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c Ipsat Therapies Oy   (Finland)

^d IPSAT Therapies Oy/Ltd   (Finland)

^e Microscreen BV   (Netherlands)

^f OHIO STATE UNIVERSITY   (United States)

^g CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; BETA LACTAMASE; TARGETED RECOMBINANT BETA LACTAMASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG TARGETING; ESCHERICHIA COLI; EXPERIMENTAL MODEL; FECES MICROFLORA; GENE; INTESTINE FLORA; MALE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE;

ADMINISTRATION, ORAL; AMPICILLIN; AMPICILLIN RESISTANCE; ANIMALS; BETA-LACTAMASES; DIGESTIVE SYSTEM; DOGS; ESCHERICHIA COLI; FECES; INFUSIONS, PARENTERAL; JEJUNUM; MALE; PENICILLINS; RECOMBINANT PROTEINS; TABLETS, ENTERIC-COATED;

EID: 9144249815     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.1.75-79.2004     Document Type: Article

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