Enzymic degradatoin of a β-lactam antibiotic, ampicillin, in the gut: A novel treatment modality

Journal of Antimicrobial Chemotherapy

Volumn 51, Issue 2, 2003, Pages 361-365

  Harmoinen, Jaana ^a   Vaali, Kirsi ^b   Koski, Pertti ^c   Syrjänen, Kaisa ^c   Laitinen, Outi ^a   Lindevall, Kai ^c   Westermarck, Elias ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Ipsat Therapies Ltd   (Finland)

Author keywords

lactamase; lactams; Jejunum; Microflora

Indexed keywords

A PEN; AMPICILLIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; EUDRAGIT; NITROCEFIN; RECOMBINANT ENZYME; PENICILLIN DERIVATIVE; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BACILLUS LICHENIFORMIS; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG POTENCY; ENTERIC COATED TABLET; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME THERAPY; GASTROINTESTINAL TRACT; INTESTINE FISTULA; INTESTINE FLORA; JEJUNUM; NONHUMAN; ANIMAL; DIGESTIVE SYSTEM; DRUG EFFECT; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MICROBIOLOGY; PH;

AMPICILLIN; ANIMALS; AREA UNDER CURVE; BETA-LACTAMASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGESTIVE SYSTEM; DOGS; HYDROGEN-ION CONCENTRATION; JEJUNUM; PENICILLINS; RECOMBINANT PROTEINS; TABLETS, ENTERIC-COATED;

EID: 0037323736     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkg095     Document Type: Article

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