CagA-positive cytotoxic H. pylori strains as a link between plaque instability and atherosclerotic stroke

European Heart Journal

Volumn 25, Issue 1, 2004, Pages 64-68

  Gabrielli, Maurizio ^a   Santoliquido, Angelo ^a   Cremonini, Filippo ^a   Cicconi, Valerio ^a   Candelli, Marcello ^a   Serricchio, Michele ^a   Tondi, Paolo ^a   Pola, Roberto ^a   Gasbarrini, Giovanni ^a   Pola, Paolo ^a   Gasbarrini, Antonio ^a,b  

^a CATHOLIC UNIVERSITY   (Italy)

^b FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Atherosclerosis; Epidemiology and prevention; Stroke

Indexed keywords

CAGA PROTEIN;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BACTERIAL STRAIN; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; STROKE;

AGED; ANTIGENS, BACTERIAL; ARTERIOSCLEROSIS; BACTERIAL PROTEINS; CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; CEREBROVASCULAR ACCIDENT; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; ODDS RATIO; RISK FACTORS; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 9144238863     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ehj.2003.10.004     Document Type: Article

References (22)

1. Markus HS, Mendall MA. Helicobacter pylori infection: a risk factor for ischaemic cerebrovascular disease and carotid atheroma. J Neurol Neurosurg Psychiatry 1998;64:104-7.
2. Whincup PH, Mendall MA, Perry IJ et al. Prospective relations between Helicobacter pylori infection, coronary heart disease and stroke in middle aged men. Heart 1996;75:568-72.
3. Grau AJ, Buggle F, Lichy C et al. Helicobacter pylori infection as an independent risk factor for cerebral ischemia of atherothrombotic origin. J Neurol Sci 2001;186:1-5.
4. Heuschmann PU, Neureiter D, Gesslein M et al. Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischaemic stroke subtypes: Results from a population-based case-control study. Stroke 2001;32:2253-8.
5. Pietroiusti A, Diomedi M, Silvestrini M et al. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation 2002;106:580-4.
6. Rothwell PM, Gibson R, Warlow CP. Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group. Stroke 2000;31:615-21.
7. De Boer OJ, Van der Wal AC, Becker AE. Atherosclerosis, inflammation and infection. J Pathol 2000;190:237-43.
8. Bodger K, Crabtree JE. Helicobacter pylori and gastric inflammation. Br Med Bull 1998;54:139-50.
9. Yamaoka Y, Kita M, Kodama T et al. Chemokines in the gastric mucosa in HP infection. Gut 1998;42:609-17.
10. Adams HP, Bendixen BH, Kappelle LJ et al. Classification of subtype of acute stroke. Definition for use in a multicenter clinical trial. Stroke 1993;24:35-41.
11. Talley NJ, Phillips SF, Melton LJ et al. A patient questionnaire to identify bowel disease. Ann Intern Med 1989;111:671-4.
12. Swenson WM, Morse RM. The use of self-administered alcoholism screening test (SAAST) in a medical center. Mayo Clin Proc 1975;50:204-8.
13. Manolio TA, Burke GL, O'Leary DH et al. Relationships of cerebral MRI findings to ultrasonographic carotid atherosclerosis in older adults: the Cardiovascular Health Study. CHS Collaborative Research Group. Arterioscler Thromb Vasc Biol 1999;19:356-65.
14. Polak JF, O'Leary DH, Kronmal RA et al. Sonographic evaluation of carotid artery atherosclerosis in the elderly: relationship of disease severity to stroke and transient ischemic attack. Radiology 1993;188:363-70.
15. Norman G, Streiner D. Biostatistics: the bare essentials. Ontario, Canada: B. C. Decker inc; 1998, p. 113-5.
16. Mayr M, Kiecht S, Mendall M et al. Increased risk of atherosclerosis is confined to CagA-positive Helicobacter pylori strains: prospective results from the Bruneck Study. Stroke 2003;34:610-5.
17. Atherton JC. Helicobacter pylori virulence factors. Br Med Bull 1998;54(1):105-20.
18. Libby P. Changing concepts of atherogenesis. J Intern Med 2000;247(3):349-58.
19. Pasceri V, Cammarota G, Patti G et al. Association of virulent Helicobacter pylori strains with ischaemic stroke. Circulation 1998;97:1675-9.
20. Blasi F, Fagetti L, Allegra L. Chlamydia pneumoniae detection atherosclerotic plaques in Italy. J Infect Dis 2000;Suppl 3:S444-6.
21. Ameriso SF, Fridman EA, Leiguarda RC et al. Detection of Helicobacter pylori in human carotid atherosclerotic plaques. Stroke 2001;32:385-91.
22. Franceschi F, Sepulveda AR, Gasbarrini A et al. Cross-reactivity between anti-CagA antibodies with vascular wall antigens. Circulation 2002;106:430-4.