Reduction of 1,2-dimethylhydrazine-induced colorectal proliferative lesions in mice by Aloe arborescens var. natalensis (Kidachi aloe)

Pharmaceutical Biology

Volumn 41, Issue 8, 2003, Pages 631-636

  Shimpo, Kan ^a   Chihara, T ^a   Shinzato, M ^a   Beppu, H ^a   Kaneko, T ^a   Shamoto, M ^a   Kuzuya, H ^a  

^a FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

1,2 dimethylhydrazine; Aloe arborescens Miller var. natalensis Berger (Kidachi aloe); Colorectal tumors

Indexed keywords

1,2 DIMETHYLHYDRAZINE; ALOE ARBORESCENS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADENOMA; ALOE; ALOE ARBORESCENS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; COLORECTAL DISEASE; CONTROLLED STUDY; DIARRHEA; FEMALE; MOUSE; NONHUMAN; PLANT LEAF; WEIGHT REDUCTION;

ACRONICTA LEPORINA; ALOE; ALOE ARBORESCENS; ALOE ARBORESCENS VAR. NATALENSIS; ANIMALIA;

EID: 9144234111     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/13880200390502612     Document Type: Article

References (38)

1. Capasso F, Borrelli F, Capasso R, Di Carlo G, Izzo AA, Pinto L, Mascolo N, Castaldo S, Longo R (1998): Aloe and its therapeutic use. Phytother Res 12: s124-s127.
2. Chihara T, Shimpo K, Shinzato M, Beppu H, Kaneko T, Ida C, Kawai K, Hirono I, Shamoto M, Nagatsu T, Kuzuya H (2000): Inhibition of N-ethyl-N′-nitro-N-nitrosoguanidine-induced duodenal tumorigenesis in mice by whole-leaf Aloe arborescens Miller van natalensis Berger. Asian Pacific J Cancer Prev 1: 283-288.
3. Fujita K (1993): Aloe arborescens Miller var. natalensis Berger. The Pharmacological and Therapeutic Effects I, pp. 5-138, Fujita Health Univ Press, Toyoake, Japan.
4. Fujita K, Suzuki I, Ochiai J, Shimpo K, Inoue S, Saito H (1978): Specific reaction of Aloe extract with serum proteins of various animals. Experientia 34: 523-524.
5. Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, Lee I-S, Hirose M (2002): Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters. Cancer Lett 178: 117-122.
6. Groom QJ, Reynolds T (1987): Barbaloin in Aloe species. Planta Med 53: 345-348.
7. Hattori M, Kanda T, Shu Y-Z, Akao T, Kobashi K, Namba T (1988): Metabolism of barbaloin by intestinal bacteria. Chem Pharm Bull 36: 4462-4466.
8. Imanishi K (1993): Aloctin A an active substance of Aloe arborescens Miller as an immunomodulator. Phytother Res 7: s20-s22.
9. Ishii Y, Tanizawa H, Ikemoto C, Takino Y (1981): Studies of aloe. 1. Cathartic effects. Yakugaku Zasshi 101: 254-258.
10. Koike T, Beppu H, Kuzuya H, Maruta K, Shimpo K, Suzuki M, Titani K, Fujita K (1995a): A 35kDa mannose-binding lectin with hemagglutinating and mitogenic activities from "Kidachi aloe" (Aloe arborescens Miller var natalensis Berger). J Biochem 118: 1205-1210.
11. Koike T, Titani K, Suzuki M, Beppu H, Kuzuya H, Maruta K, Shimpo K, Fujita K (1995b): The complete amino acid sequence of a mannose-binding lectin from "Kidachi aloe" (Aloe arborescens Miller var natalensis Berger). Biochem Biophys Res Commun 214: 163-170.
12. Kuzuya H, Tamai I, Beppu H, Shimpo K, Chihara T (2001): Determination of aloenin, barbaloin and isobarbaloin in Aloe species by micellar electrokinetic chromatography. J Chromatogr B 752: 91-97.
13. Lingeman CH, Garner FM (1972): Comparative study of intestinal adenocarcinomas of animals and man. J Natl Cancer Inst 48: 325-346.
14. Mascolo N, Mereto E, Borrelli F, Orsi P, Sini D, Izzo AA, Massa B, Boggio M, Capasso F (1999): Does senna extract promote growth of aberrant crypt foci and malignant tumors in rat colon? Dig Dis Sci 44: 2226-2230.
15. Mereto E, Ghia M, Brambilla G (1996): Evaluation of the potential carcinogenic activity of senna and cascara glycosides for the rat colon. Cancer Lett 101: 79-83.
16. Mori H, Sugie S, Niwa K, Takahashi M, Kawai K (1985): Induction of intestinal tumours in rats by chrysazin. Br J Cancer 52: 781-783.
17. Mori H, Sugie S, Niwa K, Yoshimi N, Tanaka T, Hirono I (1986): Carcinogenicity of chrysazin in large intestine and liver of mice. Jpn J Cancer Res 77: 871-876.
18. Mori H, Yoshimi N, Iwata H, Mori Y, Hara A, Tanaka T, Kawai K (1990): Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms. Carcinogenesis 11: 799-802.
19. Obata M, Ito S, Beppu H, Fujita K, Nagatsu T (1993): Mechanism of antiinflammatory and antithermal burn action of CPase from Aloe arborescens Miller var. natalensis Berger in rats and mice. Phytother Res 7: s30-s33.
20. Saito H (1993): Purification of active substances of Aloe arborescens Miller and their biological and pharmacological activity. Phytother Res 7: s14-s19.
21. Sato Y, Ohta S, Shinoda M (1990): Studies on chemical protectors against radiation. XXXI. Protection effects of Aloe arborescens on skin injury induced by X-irradiation. Yakugaku Zasshi 110: 876-884.
22. Shimpo K, Chihara T, Beppu H, Kaneko T, Ida C, Nagatsu T, Kuzuya H (1999): Inhibitory effects of JP aloe and aloin on the formation of aberrant crypt foci in rat colorectum induced by azoxymethane. Fujita-Gakuen Igakkaishi (Bull Fujita Med Soc) 23: 123-127.
23. Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Nagatsu T, Kuzuya H (2001a): Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. natalensis Berger. Phytother Res 15: 705-711.
24. Shimpo K, Chihara T, Ida C, Kaneko T, Beppu H, Kuzuya H (2001b): Inhibitory effects of Aloe on the formation of aberrant crypt foci in rat colorectum induced by azoxymethane - Modulation of phase 2 detoxification enzymes. Fujita-Gakuen Igakkaishi (Bull Fujita Med Soc) 25: 89-93.
25. Siegers C-P (1992): Anthranoid laxatives and colorectal cancer. Trends Pharmacol Sci 13: 229-231.
26. Siegers C-P, Siemers J, Baretton G (1993): Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice. Pharmacology 47(suppl 1): 205-208.
27. Sohn OS, Ishizaki H, Yang CS, Fiala ES (1991): Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12: 127-131.
28. Sugie S, Mori Y, Okumura A, Yoshimi N, Okamoto K, Sato S, Tanaka T, Mori H (1994): Promoting and synergistic effects of chrysazin on 1,2- dimethylhydrazine-induced carcinogenesis in male ICR/CD-1 mice. Carcinogenesis 15: 1175-1179.
29. Suzuki I, Saito H, Inoue S, Migita S, Takahashi T (1979): Purification and characterization of two lectins from Aloe arborescens Mill. J Biochem 85: 163-171.
30. Teradaira R, Shinzato M, Beppu H, Fujita K (1993): Antigastric ulcer effects in rats of Aloe arborescens Miller var. natalensis Berger extract. Phytother Res 7: s34-s36.
31. Thurnherr N, Deschner EE, Stonehill EH, Lipkin M (1973): Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res 33: 940-945.
32. Tsuda H, Matsumoto K, Ito M, Hirono I, Kawai K, Beppu H, Fujita K, Nagao M (1993): Inhibitory effect of Aloe arborescens Miller var. natalensis Berger (Kidachi aloe) on induction of preneoplastic focal lesions in the rat liver. Phytother Res 7: s43-s47.
33. Uehara N, Iwahori Y, Asamoto M, Baba-Toriyama H, Iigo M, Ochiai M, Nagao M, Nakayama M, Degawa M, Matsumoto K, Hirono I, Beppu H, Fujita K, Tsuda H (1996): Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with β-carotene, α-tocopherol and freeze-dried aloe. Jpn J Cancer Res 87: 342-348.
34. Van Gorkom BAP, De Vries EGE, Karrenbeld A, Kleibeuker JH (1999): Anthranoid laxatives and their potential carcinogenic effects. Aliment Pharmacol Ther 13: 443-452.
35. Yagi A (1993): Chemical and pharmacological studies on Aloe. Annual Report of the Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University 11: 27-45.
36. Yagi A, Machii K, Nishimura H, Shida T, Nishioka I (1985): Effect of aloe lectin on deoxyribonucleic acid synthesis in baby hamster kidney cells. Experientia 41: 669-671.
37. Yamamoto M, Masui T, Sugiyama K, Yokota M, Nakagomi K, Nakazawa H (1991): Anti-inflammatory active constituents of Aloe arborescens Miller. Agric Biol Chem 55: 1627-1629.
38. Yamamoto M, Maeda Y, Nakazawa H (1995): Biological activities of Aloes and evaluations of foods containing Aloes. Foods and Food Ingredients J Jpn 164: 22-35.