Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population

Neuroscience Letters

Volumn 355, Issue 1-2, 2004, Pages 149-151

  Liu, Lin Lin ^a   Wei, Jun ^b   Zhang, Xuan ^a   Li, Xiu Yi ^a   Shen, Yan ^c   Liu, Shu Zheng ^a   Ju, Gui Zhi ^a   Shi, Jie Ping ^a   Yu, Ya Qin ^a   Xu, Qi ^c   Hemmings, Gwynneth P ^b  

^a JILIN UNIVERSITY   (China)

^b Schizophrenia Assoc of Gt Britain   (United Kingdom)

^c CHINESE NATIONAL HUMAN GENOME CENTER AT SHANGHAI   (China)

Author keywords

Chromosome 6p; Genetic heterogeneity; Human major histocompatibility complex; Schizophrenia; Single nucleotide polymorphisms; Tenascin X (TNXA)

Indexed keywords

TENASCIN; TENASCIN X; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CHINA; CHINESE; CHROMOSOME MAP; CONTROLLED STUDY; FEMALE; GENE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC SCREENING; GENETICS; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPRODUCIBILITY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM; TENASCIN X GENE;

EID: 9144222219     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2003.10.059     Document Type: Article

References (17)

1. Boin F., Zanardini R., Pioli R., Altamura C.A., Maes M., Gennarelli M. Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol. Psychiatry. 6:2001;79-82.
2. Bristow J., Tee M.K., Gitelman S.E., Mellon S.H., Miller W.L. Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B. J. Cell Biol. 122:1993;265-278.
3. Cardon L.R., Palmer L.J. Population stratification and spurious allelic association. Lancet. 361:(2003):2003;598-604.
4. Cichon S., Schumacher J., Ivo R., Macchiardi F., Schulze T.G., M?ller D.J., Kremer I., Dobrusin M., Mujaheed M., Murad I., Blanaru M., Bannoura I., Reshef A., Bachner-Melman R., Belmaker R.H., Ebstein R.P., Maier W., Rietschel M., Propping P., Nöthen M.M. The NOTCH4 locus and schizophrenia: analyses in the German and Palestinian Arab population. Am. J. Med. Genet. 105:(Suppl.):2001;571. (Abstr).
5. Colhoun H.M., McKeigue P.M., Smith G.D. Problems of reporting genetic associations with complex outcomes. Lancet. 361:2003;865-872.
6. Erickson H.P. Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions. Curr. Opin. Cell Biol. 5:1993;869-876.
7. Fuss B., Wintergerst E.S., Bartsch U., Schachner M. Molecular characterization and in situ mRNA localization of the neural recognition molecule J1-160/180: a modular structure similar to tenascin. J. Cell Biol. 120:1993;1237-1249.
8. Gotz B., Scholze A., Clement A., Joester A., Schutte K., Wigger F., Frank R., Spiess E., Ekblom P., Faissner A. Tenascin-C contains distinct adhesive, and neurite outgrowth promoting sites for neurons. J. Cell Biol. 132:1996;681-699.
9. Meiners S., Mercado M.L., Nur-e-Kamal M.S., Geller H.M. Tenascin-C contains that independently regulate neurite outgrowth and neurite guidance. J. Neurosci. 19:1999;8443-8453.
10. Mjellem N., Kringlen E. Schizophrenia: a review, with emphasis on the neurodevelopmental hypothesis. Nord. J. Psychiatry. 55:2001;301-309.
11. Rigato F., Garwood J., Calco V., Heck N., Faivre-Sarrailh C., Faissner A. Tenascin-C promotes neurite outgrowth of embryonic hippocampal neurons through the alternatively spliced fibronectin type III BD domains via activation of the cell adhesion molecule F3/contactin. J. Neurosci. 22:2002;6596-6609.
12. Skol A.D., Young K.A., Tsuang D.W., Faraone S.V., Haverstock S.L., Bingham S., Prabhudesai S., Mena F., Menon A.S., Yu C.E., Rundell P., Pepple J., Sauter F., Baldwin C., Weiss D., Collins J., Keith T., Boehnke M., Schellenberg G.D., Tsuang M.T. Modest evidence for linkage and possible confirmation of association of between NOTCH4 and schizophrenia in a large veterans affairs cooperative study sample. Am. J. Med. Genet. 118B:2003;8-15.
13. Complete sequence and gene map of a human major histocompatibility complex. Nature. 401:1999;921-923.
14. Wei J., Hemmings G.P. The NOTCH4 locus is associated with susceptibility to schizophrenia. Nat. Genet. 25:2000;376-377.
15. Wei J., Hemmings G.P. The TNXB locus may be a candidate gene predisposing to schizophrenia. Am. J. Med. Genet. 2004;. (in press).
16. Wright P., Nimgaonkar V.L., Donaldson P.T., Murray R.M. Schizophrenia and HLA: a review. Schizophr. Res. 47:2001;1-12.
17. Zhang X., Wei J., Yu Y.-Q., Liu S.-Z., Shi J.P., Liu L.-L., Ju G.-Z., Yang J.-Z., Zhang D., Xu Q., Shen Y., Hemmings G.P. Is NOTCH4 associated with schizophrenia? Psychiat. Genet. 2003;. (in press).