Effects of atipamezole - A selective α2-adrenoceptor antagonist - On cardiac parasympathetic regulation in human subjects

Autonomic and Autacoid Pharmacology

Volumn 24, Issue 3, 2004, Pages 69-75

  Penttila J ^a,b   Kaila, T ^c   Helminen, A ^a,d   Anttila, M ^e   Karhuvaara, S ^e   Huhtala, S ^a   Scheinin, H ^a,f  

^a UNIVERSITY OF TURKU   (Finland)

^b PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e ORION CORPORATION   (Finland)

^f TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Atipamezole; Heart rate variability; Parasympathetic nervous system

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ATIPAMEZOLE;

ADULT; ARTERIAL PRESSURE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INFUSION; ELECTROCARDIOGRAM; HEART REPOLARIZATION; HUMAN; MALE; NORMAL HUMAN; PARASYMPATHETIC NERVE CELL; PRESSORECEPTOR REFLEX; RR INTERVAL; STEADY STATE; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; BAROREFLEX; BLOOD PRESSURE; CROSS-OVER STUDIES; ELECTROCARDIOGRAPHY; HEART; HEART RATE; HUMANS; IMIDAZOLES; MALE; PARASYMPATHETIC NERVOUS SYSTEM; PHENYLEPHRINE; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 8844286066     PISSN: 14748665     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-8673.2004.00318.x     Document Type: Article

References (40)

1. ANDREJAK, M., WARD, M. & SCHMITT, H. (1983). Cardiovascular effects of yohimbine in anaesthetized dogs. Eur. J. Pharmacol., 94, 219-228.
2. BERLAN, M., MONTASTRUC, J.L. & LAFONTAN, M. (1992). Pharmacological prospects for alpha 2-adrenoceptor and antagonist therapy. Trends Pharmacol. Sci., 13, 277-282.
3. BROWN, T.E., BEIGHTOL, L.A., KOH, J. & ECKBERG, D.L. (1993). Important influence of respiration on human R-R interval power spectra is largely ignored. J. Appl. Physiol., 75, 2310-2317.
4. CHAPLEO, B. (1988). The discovery and therapeutic potential of selective alpha 2-adrenoceptor antagonists. In: Recent Advances in Receptor Chemistry (Eds C. MELCHIORRE & M. GIANELLA), pp. 85-106. Elsevier Science Publishers, Amsterdam, the Netherlands.
5. CIVANTOS CALZADA, B. & ALEIXANDRE DE ARTINANO, A. (2001). Alpha-adrenoceptor subtypes. Pharmacol. Res., 44, 195-208.
6. DAMASE-MICHEL, C., TRAN, M.A., LLAU, M.E., CHOLLET, F., SENARD, J.M., GUIRAUD-CHAUMEIL, B., MONTASTRUC, J.L. & MONTASTRUC, P. (1993). The effect of yohimbine on sympathetic responsiveness in essential hypertension. Eur. J. Clin. Pharmacol., 44, 199-201.
7. DODA, M. (1997). Role of different subtypes of adrenoceptors in pressor responses to catecholamines released from sympathetic nerve endings. Brain Res. Bull., 42, 51-57.
8. ELGHOZI, J.L., LAUDE, D. & JANVIER, F. (1991). Clonidine reduces blood pressure and heart rate oscillations in hypertensive patients. J. Cardiovasc. Pharmacol., 17, 935-940.
9. ELLIOTT, H.L., JONES, C.R., VINCENT, J., LAWRIE, C.B. & REID, J.L. (1984). The alpha adrenoceptor antagonist properties of idazoxan in normal subjects. Clin. Pharmacol. Ther., 36, 190-196.
10. GOLDBERG, M.R., HOLLISTER, A.S. & ROBERTSON, D. (1983). Influence of yohimbine on blood pressure, autonomic reflexes and plasma catecholamines in humans. Hypertension, 5, 772-778.
11. HAYANO, J., SAKAKIBARA, Y., YAMADA, A., YAMADA, M., MUKAI, S., FUJINAMI, T., YOKOYAMA, K., WATANABE, Y. & TAKATA, K. (1991). Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am. J. Cardiol., 67, 199-204.
12. HUUPPONEN, R., KARHUVAARA, S., ANTTILA, M., VUORILEHTO, L. & SCHEININ, H. (1995). Buccal delivery of an alpha 2-adrenergic receptor antagonist, atipamezole, in humans. Clin. Pharmacol. Ther., 58, 506-511.
13. KARHUVAARA, S., KALLIO, A., SCHEININ, M., KOULU, M., SCHEININ, H. & VIIKARI, J. (1989). Tolerability and effects of atipamezole, a novel alpha 2-adrenoceptor antagonist, in healthy male volunteers. Curr. Ther. Res., 45, 633-642.
14. KARHUVAARA, S., KALLIO, A., SCHEININ, M., ANTTILA, M., SALONEN, J.S. & SCHEININ, H. (1990). Pharmacological effects and pharmacokinetics of atipamezole, a novel alpha 2-adrenoceptor antagonist - a randomized, double-blind cross-over study in healthy male volunteers. Br. J. Clin. Pharmacol., 30, 97-106.
15. LOIACONO, R.E. & STORY, D.F. (1986). Effect of alpha-adrenoceptor agonists and antagonists on cholinergic transmission in guinea-pig isolated atria. Naunyn-Schmiedeberg's Arch. Pharmacol., 334, 40-47.
16. McCALL, R.B., SCHUETTE, M.R., HUMPHREY, S.J., LAHTI, R.A. & BARSUHN, C. (1983). Evidence for a central sympathoexcitatory action of alpha-2 adrenergic antagonists. J. Pharmacol. Exp. Ther., 224, 501-507.
17. MEDIGUE, C., GIRARD, A., LAUDE, D., MONTI, A., WARGON, M. & ELGHOZI, J.L. (2001). Relationship between pulse interval and respiratory sinus arrhythmia: a time- and frequency-domain analysis of the effects of atropine. Pflugers Arch., 441, 650-655.
18. MOSQUEDA-GARCIA, R., EERNANDEZ-VIOLANTE, R., TANK, J., SNELL, M., CUNNINGHAM, G. & FURLAN, R. (1998). Yohimbine in neurally mediated syncope. Pathophysiological implications. J. Clin. Invest., 102, 1824-1830.
19. NEWMAN-TANCREDI, A., NICOLAS, J.P., AUDINOT, V., GAVAUDAN, S., VERRIELE, L., TOUZARD, M., CHAPUT, C., RICHARD, N. & MILLAN, M.J. (1998). Actions of alpha2-adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors. Naunyn-Schmiedeberg's Arch. Pharmacol., 358, 197-206.
20. PAGANI, M., LOMBARDI, F., GUZZETTI, S. et al. (1986). Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circ. Res., 59, 178-193.
21. PARATI, G., DI RIENZO, M. & MANCIA, G. (2000). How to measure baroreflex sensitivity: from the cardiovascular laboratory to daily life. J. Hypertens., 18, 7-19.
22. PARLOW, J.L., BEGOU, G., SAGNARD, P. et al. (1999). Cardiac baroreflex during the postoperative period in patients with hypertension: effect of clonidine. Anesthesiology, 90, 681-692.
23. PENTTILÄ, J., HELMINEN, A., JARTTI, T., KUUSELA, T., HUIKURI, H.V., TULPPO, M.P., COFFENG, R. & SCHEININ, H. (2001a). Time domain, geometrical and frequency domain analysis of cardiac vagal outflow: effects of various respiratory patterns. Clin. Physiol., 21, 365-376.
24. PENTTILÄ, J., HELMINEN, A., LUOMALA, K. & SCHEININ, H. (2001b). Pharmacokinetic-pharmacodynamic model for the anticholinergic effect of glycopyrrolate. Eur. J. Clin. Pharmacol., 57, 153-158.
25. PENTTILÄ, J., SYVÄLAHTI, E., HINKKA, S., KUUSELA, T. & SCHEININ, H. (2001c). The effects of amitriptyline, citalopram and reboxetine on autonomic nervous system. A randomised placebo-controlled study on healthy volunteers. Psychopharmacology (Berl.), 154, 343-349.
26. PENTTILÄ, J., HELMINEN, A., ANTTILA, M., HINKKA, S. & SCHEININ, H. (2004). Cardiovascular and parasympathetic effects of dexmedetomidine in healthy subjects. Can. J. Physiol. Pharmacol., 82, 359-362.
27. POMERANZ, B., MACAULAY, R.J., CAUDILL, M.A. et al. (1985). Assessment of autonomic function in humans by heart rate spectral analysis. Am. J. Physiol., 248, H151-H153.
28. RAMAGE, A.G. & TOMLINSON, A. (1985). The effect of yohimbine, WY 26392 and idazoxan on sympathetic nerve activity. Eur. J. Pharmacol., 109, 153-160.
29. SCHEININ, H., MACDONALD, E. & SCHEININ, M. (1988). Behavioural and neurochemical effects of antipamezole, a novel alpha 2-adrenoceptor antagonist. Eur. J. Pharmacol., 151, 35-42.
30. SCHEININ, H., HELMINEU, A., HUHTALA, S. GRÖNROOS, P., BOSCH, J.A., KUUSELA, T., KANTO, J. & KAILA, T. (1999). Spectral analysis of heart rate variability as a quantitative measure of parasympatholytic effect - integrated pharmacokinetics and pharmacodynamics of three anticholinergic drugs. Ther. Drug Monit., 21, 141-151.
31. SENARD, J.M., RASCOL, O., DURRIEU, G., TRAN, M.A., BERLAN, M., RASCOL, A. & MONTASTRUC, J.L. (1993). Effects of yohimbine on plasma catecholamine levels in orthostatic hypotension related to Parkinson's disease or multiple system atrophy. Clin. Neuropharmacol., 16, 70-76.
32. SHIN, K., MINAMITANI, H., ONISHI, S., YAMAZAKI, H. & LEE, M. (1997). Autonomic differences between athletes and nonathletes: spectral analysis approach. Med. Sci. Sports Exerc., 29, 1482-1490.
33. SJÖHOLM, B., SAVOLA, J.M. & SCHEININ, M. (1995). Nonadrenergic binding of [3H]atipamezole in rat lung. A novel imidazole binding site? Ann. N. Y. Acad. Sci., 763, 66-77.
34. SZABADI, E., BRADSHAW, C.M., BOSTON, P.F. & LANGLEY, R.W. (1998). The human pharmacology of reboxetine. Hum. Psychopharmacol. Clin. Exp., 13, S3-S12.
35. TASK FORCE OF THE EUROPEAN SOCIETY OF CARDIOLOGY AND THE NORTH AMERICAN SOCIETY OF PACING AND ELECTROPHYSIOLOGY (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Circulation, 93, 1043-1065.
36. TELLEZ, S., COLPAERT, F. & MARIEN, M. (1999). Alpha2-adrenoceptor modulation of cortical acetylcholine release in vivo. Neuroscience, 89, 1041-1050.
37. TULEN, J.H., SMEETS, F.M., MAN IN 'T VELD, A.J., VAN STEENIS, A.J. VAN DE WETERING, B.J. & MOLEMAN, P. (1993). Cardiovascular variability after clonidine challenge: assessment of dose-dependent temporal effects by means of spectral analysis. J. Cardiovasc. Pharmacol., 22, 112-119.
38. UNNERSTALL, J.R., KOPAJTIC, T.A. & KUHAR, M.J. (1984). Distribution of alpha 2-agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res. Rev., 7, 69-101.
39. VAYSSETTES-COURCHAY, C., BOUYSSET, F., CORDI, A.A., LAUBIE, M. & VERBEUREN, T.J. (1996). A comparative study of the reversal by different alpha 2-adrenoceptor antagonists of the central sympatho-inhibitory effect of clonidine. Br. J. Pharmacol., 117, 587-593.
40. VIRTANEN, R., SAVOLA, J.M. & SAANO, V. (1989). Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch. Int. Pharmacodyn. Ther., 297, 190-204.