Minimal self-replicating systems

Current Opinion in Chemical Biology

Volumn 8, Issue 6, 2004, Pages 634-639

  Paul, Natasha ^a   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; DEOXYRIBOZYME; DICYCLOHEXYLCARBODIIMIDE; NUCLEIC ACID; PEPTIDE;

CATALYSIS; GENE REPLICATION; MEDICAL RESEARCH; NUCLEOTIDE SEQUENCE; REVIEW;

BIOGENESIS; CATALYSIS; NUCLEIC ACIDS; PEPTIDES; RNA, CATALYTIC; TEMPLATES, GENETIC;

EID: 8844245640     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2004.09.005     Document Type: Review

References (28)

1. M.M. Conn, and J. Rebek Jr. The design of self-replicating molecules Curr Opin Struct Biol 4 1994 629 635
2. B.G. Bag, and G. von Kiedrowski Templates, autocatalysis and molecular replication Pure Appl Chem 68 1996 2145 2152
3. A. Robertson, A.J. Sinclair, and D. Philp Minimal self-replicating systems Chem Soc Rev 29 2000 141 152
4. N. Paul, and G.F. Joyce Self-replication Curr Biol 13 2003 R46
5. G. von Kiedrowski A self-replicating hexadeoxynucleotide Angew Chem 25 1986 932 935
6. W.S. Zielinski, and L.E. Orgel Autocatalytic synthesis of a tetranucleotide analogue Nature 327 1987 346 347
7. G. von Kiedrowski, B. Wlotzka, J. Helbing, M. Mazten, and S. Jordan Parabolic growth of a self-replicating hexadeoxynucleotide bearing a 3′-5′-phosphoamidate linkage Angew Chem 30 1991 423 426
8. N. Paul, and G.F. Joyce A self-replicating ligase ribozyme Proc Natl Acad Sci USA 99 2002 12733 12740 This article describes a self-replicating system based on an RNA template that also functions as a ribozyme to catalyze its own replication. It is the first example of a self-replicating system with a reaction order of 1.0.
9. D.H. Lee, J.R. Granja, J.A. Martinez, K. Severin, and M.R. Ghadiri A self-replicating peptide Nature 382 1996 525 528
10. D.H. Lee, K. Severin, Y. Yokobayashi, and M.R. Ghadiri Emergence of symbiosis in peptide self-replication through a hypercyclic network Nature 390 1997 591 594
11. S. Yao, I. Ghosh, R. Zutshi, and J. Chmielewski A pH-modulated, self-replicating peptide J Am Chem Soc 119 1997 10559 10560
12. S. Yao, I. Ghosh, R. Zutshi, and J. Chmielewski Selective amplification by auto- and cross-catalysis in a replicating peptide system Nature 396 1998 447 450
13. R. Issac, and J. Chmielewski Approaching exponential growth with a self-replicating peptide J Am Chem Soc 124 2002 6808 6809 This communication describes a peptide-based replicator with shortened substrate-recognition domains. The template-product complex was somewhat destabilized, resulting in a reaction order of 0.91.
14. X. Li, and J. Chmielewski Peptide self-replication enhanced by a proline link J Am Chem Soc 125 2003 11820 11821 This communication describes a peptide-based self-replicating system in which a proline residue was introduced to cause a kink in the templating surface. This substitution destabilized the template-product complex, resulting in improved product release and a reaction order of 0.91.
15. T. Tijvikua, P. Ballester, and J. Rebek Jr. A self-replicating system J Am Chem Soc 112 1990 1249 1250
16. A. Terfort, and G. von Kiedrowski Self-replication by condensation of 3-aminobenzamides and 2-formylphenoxyacetic acids Angew Chem 31 1992 654 656
17. E.A. Wintner, M.M. Conn, and J. Rebek Jr. Self-replicating molecules: a second generation J Am Chem Soc 116 1994 8877 8884
18. G. von Kiedrowski Minimal replicator theory I: parabolic versus exponential growth H. Dugas Bioorganic Chemistry vol 3 1993 Springer-Verlag Berlin, Heidelberg 115 146
19. R. Issac, Y.-W. Ham, and J. Chmielewski The design of self-replicating helical peptides Curr Opin Struct Biol 11 2001 458 463
20. P.E. Dawson, T.W. Muir, I. Clark-Lewis, and S.B.H. Kent Synthesis of proteins by native chemical ligation Science 266 1994 776 779
21. J. Rogers, and G. Joyce The effect of cytidine on the structure and function of an RNA ligase ribozyme RNA 7 2001 395 404
22. S.W. Santoro, and G.F. Joyce A general purpose RNA-cleaving DNA enzyme Proc Natl Acad Sci USA 94 1997 4262 4266
23. M. Levy, and A.D. Ellington Exponential growth by cross-catalytic cleavage of deoxyribozymogens Proc Natl Acad Sci USA 100 2003 6416 6421 This article describes a deoxyribozyme-based, cross-catalytic amplification system in which efficient product release was achieved through cleavage, rather than a joining reaction. Optimal sequences of the substrate-recognition domains were isolated by in vitro selection.
24. D. Sievers, and G. von Kiedrowski Self-replication of complementary nucleotide-based oligomers Nature 369 1994 221 224
25. J. Chen, S. Korner, S.L. Craig, D.M. Rudkevich, and J. Rebek Jr. Amplification by compartmentalization Nature 415 2002 385 386 This paper describes a chemical amplification system in which release of a precursor reagent from a compartment led to the formation of two product molecules, each of which promoted the release of two additional precursor molecules. The rate of precursor release was found to increase exponentially over time.
26. ••], with emphasis on the autocatalytic nature of product uptake into the compartments.
27. T. Achilles, and G. von Kiedrowski A self-replicating system from three starting materials Angew Chem 32 1993 1198 1201
28. G. Ashkenasy, R. Jagasia, M. Yadav, and M.R. Ghadiri Design of a directed molecular network Proc Natl Acad Sci USA 101 2004 10872 10877 This article describes the design and implementation of a network of nine α-helical peptides that direct each other's synthesis through various autocatalytic and cross-catalytic pathways. The network has a complex topology, including two-, three- and four-member cross-catalytic cycles.