Infectious plasmid resistance and efflux pump mediated resistance

Acta Microbiologica et Immunologica Hungarica

Volumn 51, Issue 3, 2004, Pages 333-349

  Molnar J ^a   Molnár, Annamária ^a   Spengler, Gabriella ^a   Mándi, Yvette ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Antibiotic resistance; Antiplasmid effect; Efflux pumps; Tricyclic compounds

Indexed keywords

ALIMEMAZINE; ANTIDEPRESSANT AGENT; CHLORPROMAZINE DERIVATIVE; CHLORPROTHIXENE; DESIPRAMINE; HETEROCYCLIC COMPOUND; LIDOCAINE; NOXIPTILINE; PLASMID DNA; PROCAINE; PROFENAMINE; PROMAZINE; PROTRIPTYLINE; THIAZINAMIUM; TOLONIUM CHLORIDE; TRIMIPRAMINE;

ANTIBIOTIC RESISTANCE; BACTERIAL CHROMOSOME; BACTERIUM CULTURE; CHEMICAL STRUCTURE; NONHUMAN; PLASMID; REVIEW; STEREOSPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 8844241542     PISSN: 12178950     EISSN: None     Source Type: Journal    
DOI: 10.1556/AMicr.51.2004.3.11     Document Type: Review

References (55)

1. Amabile Cuevas, C. F., Chicure, M. E.: Bacterial plasmids gene flux. Cell 70, 189-199 (1992).
2. Davies, J.: Inactivation of antibiotics and the dissemination of resistance genes. Science 264, 375-382 (1994).
3. Shaw, K. J., Rather, P. N., Hare, R. S., Miller, G. H.: Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev 57, 138-163 (1993).
4. Nikaido, H.: Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264, 382-388 (1994).
5. Nikaido, H.: Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. Cell & Developmental Biology 12, 215-223 (2001).
6. Levy, S.: Active efflux mechanisms for antibiotic resistance. Antimicrob Agents. Chemother 36, 695-703 (1992).
7. Mándi, Y., Molnár, J., Holland, I. B., Bélá di, I.: Efficient curing of an Escherichia coli F-prime plasmid by phenothiazines. Genet Res Camb 26, 109-111 (1976).
8. Molnár, J., Király, J., Mándi, Y.: The antibacterial action of R-factor inhibiting activity by chlorpromazine. Experientia 31, 444-445 (1975).
9. Molnár, J., Batho, N., Csik, V., Chevalier, J., Cremieux, A.: Interaction between tricyclic psychopharmacons and antibiotics. Acta Microbiol Hung 40, 91-99 (1993).
10. Barabás, K., Molnár, J.: Lack of correlation between intercalation and plasmid curing ability of some tricyclic compounds. Acta Microbiol Acad Sci Hung 27, 55-61 (1980).
11. Molnár, J.: Antiplasmid activity of tricyclic compounds. Meth Find Exp Clin Pharmacol 10(7), 467-474 (1988).
12. Molnár, J., Földeák, S., Nakamura, M. J., Rausch, H., Domonkos, K., Szabó, M.: Antiplasmid activity: loss of bacterial resistance to antibiotics. APMIS Suppl. 30/100, 25-32 (1992).
13. Molnár, J., Mándi, Y., Földeák, S.: Drug-receptor interaction on plasmid elimination by phenothiazines and imipramine in Escherichia coli. Acta Microbiol Acad Sci Hung 29, 17-25 (1982)
14. Molnár, J., Bathó, N., Csík, V., Chevalier, J., Cremieux, A.: Interaction between tricyclic psychopharmacons and some antibiotics. Acta Microbiol Immunol Hung 42, 277-285 (1995).
15. Miskolci, Cs., Labádi, I., Kurihara, T., Motohashi, N., Molnár, J.: Guanine-cytosine rich regions of plasmid DNA can be the target in anti-plasmid effect of phenothiazines. Int J Antimicrob Agents 14, 243-247 (2000).
16. Kurihara, T., Motohashi, N., Kobayashi, H., Yamanaka, W., Dohyashki, S-I., Molnár, J.: Interaction of chlorpromazine with 2′- deoxyguanosine-5′-monophosphate by PM3 calculation. Anticancer Res 18, 3493-3498 (1998).
17. Szabó, M., Molnár, J., Bánfalvi, Zs., Motohashi, N.: Inhibition of tumor induction by Agrobacterium tumefaciens and nodulation induced by Rhisobium meliloti in the presence of phenothiazines and structurally related compounds. Anticancer Res 12, 1667-1670 (1992).
18. Molnár, J., Nakamura, M. J.: Virulence associated plasmid and R-plasmid curing in Yersinia enterocolitica by some tricyclic compounds. Acta Microbiol Hung 35, 309-314 (1988).
19. Mándi, Y., Molnár, J.: Effect of chlorpromazine on conjugal plasmid transfer and sex pili. Acta Microbiol Acad Sci Hung 28, 205-210 (1981).
20. Csiszár, K., Molnár, J.: Mechanism of tricyclic drugs on Escherichia coli and Yersinia enterocolitica plasmid maintenance and replication. Anticancer Res 12, 2267-2272 (1992).
21. Molnár, J., Mucsi, I., Kása, P.: Inhibition of the adhesion of E. coli on cultured human epithelial cells in the presence of promethazine or imipramine. Zbl Bakt Hyg I Abt Orig A 254, 388-396 (1983).
22. Molnár, J., Haszon, I., Bodrogi, T., Martonyi, E., Turi, S.: Synergistic effect of promethazine with Gentamicin in frequently reccurring pyelonephritis. Int J Urol Nephrol 22/5, 405-411 (1990).
23. Kásler, M., Molnár, J., Ágoston, E., Poczik, M.: A Gentamicin-Pipolphen gyógyszerkombináció alkalmazásának tapasztalatai polyresistens baktériumtö rzsek okozta urogenitális fertozésekben. Urol Nephrol Szle 9(3), 135-138 (1982).
24. Kásler, M., Molnár, J., Poczik, M.: A Pipolphen plazmidtörlo hatásának vizsgálata urogenitális fertozések esetén. Urol Nephrol Szle 9(3) 130-133 (1982).
25. Methar, S., Blakemore, Ph. D., Ellis, K.: In vivo curing of plasmids from multidrug-resistant Serratia marcescens by ciprofloxacine. Amer J Medicine 82(4a), 55-57 (1987).
26. Molnár, J.: Fenotiazinok és hasonló szerkezetu vegyületek antibakteriális, valamint plazmid repliká ciót gátló hatásai. Doktori értekezés (1986).
27. Molnár, J., Gálfi, M., Lózsa, A., Nakamura, M. J.: Inhibition of bacterial plasmid replication by stereoselective binding of tricyclic psychopharmacons. Res Commun Chem Pathol Pharmacol 43, 235-249 (1984).
28. Molnár, J., Földeák, S., Nakamura, M. J., Gaizer, F., Gutmann, F.: The influence of charge transfer complex formation on the antibacterial activity of some tricyclic drugs. Xenobiotica 21, 309-319 (1991).
29. Molnár, J., Petofi, Sz., Kurihara, T., Sakagami, H., Motohashi, N.: Antiplasmid and carcinogenic molecular orbitals of benz(c)acridine and related compounds. Anticancer Res 13, 263-266 (1993).
30. Molnár, J., Sakagami, H., Motohashi, N.: Diverse biological activities displayed by phenothiazines, benzo(a)phenothiazines and benz(c)acridines (Review). Anticancer Res 13, 1019-1026 (1993).
31. Molnár, J.: The role of charge distribution of tricyclic compounds in the antibacterial, antiviral and antiplasmid effects. In: Keyzer, N., Gutmann, F., Eckert, G. (eds), Electropharmacology. CRC, 205-219 (1990).
32. Molnár, J., Földeák, S., Hegyes, P., Schneider, B., Holland, I. B.: New plasmid curing compounds. Anthril and phenathril derivatives. Biochem Pharmacol 28, 261-265 (1979).
33. Molnár, J.: New drug effects on bacteria, the antiplasmid effect. Acta Microbiol Immunol Hung 44, 21-26 (1997).
34. Molnár, J., Schneider, B.: Plasmid curing and antibacterial effects of some chlorpromazine derivatives in relation to their molecular orbitals. Acta Microbiol Acad Sci Hung 25, 291-298 (1978).
35. Farkas, S., Molnár, J.: Elimination of F'lac plasmid by different psychotropic drugs and some related compounds. Acta Microbiol Acad Sci Hung 26, 351-361 (1979).
36. Motohashi, N., Sakagami, H., Kurihara, T., Csúri, K., Molnár, J.: Antiplasmid activity of phenothiazines, benzo(a) phenothiazines and benz(c)acridines. Anticancer Res 12, 135-140 (1992).
37. Molnár, J., Földeák, S.: Rezisztencia elleni gyógyszerek tervezése. Gyógyszerészet 38, 1-7 (1994).
38. Molnár, J.: Gyógyszer-rezisztencia visszafordí tása a baktériumoktól a daganatsejtekig. (Gyógyszerkutatás elore megtervezett hatású vegyületek eloállításával.) Orv Hetil 140, 2155-2160 (1999).
39. Molnár, J., Béládi, I., Holland, I. B.: The plasmid curing action of imipramine in Escherichia coli K 12. Genet Res Camb 31, 197-201 (1978).
40. Molnár, J., Csiszár, K., Nishioka, I., Shoyama, Y.: The effects of cannabispiro compounds and tetrahydrocannabidiolic acid on the plasmid transfer and maintenance in Escherichia coli. Acta Microbiol Hung 33, 221-231 (1986).
41. Tanaka, M., Wayda, K., Molnár, J., Párkányi, C., Aaron, J.-J., Motohashi, N.: Antimutagenicity of benzo[a]phenothiazines in chemically induced mutagenesis. Anticancer Res 17, 839-842 (1997).
42. Motohashi, N., Kawase, M., Saito, S., Miskolci, Cs., Berek, L., Molnár, J.: Plasmid elimination and immunomodulation by 3-benzazepines in vitro. Anticancer Res 19, 5075-5078 (1999).
43. Gerlach, J. H., Endicott, J. A., Juranka, P. F., Henderson, G., Sarang Deuchars, K. I., Victor Victor Ling: Homology between p-glycoprotein and bacterial hemolysin transport protein suggests a model for multidrug resistance. Nature 324, 485-489 (1986).
44. Gross, P., Croop, J., Housman, D.: Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 47, 371-390 (1986).
45. Molnar, J., Hevér, A., Fakla, I., Fischer, J., Ocsovszki, I., Aszalos, A.: Inhibition of the transport function of membrane proteins by some substituted phenothiazines in E. coli and multidrug resistant tumor cells. Anticancer Res 17, 481-486 (1997).
46. Lewis, K., Hooper, D. C., Ouellette, M.: Multidrug resistance pumps provide broad defense. ASM News 63, 605-610 (1997).
47. Nikaido, H.: Multidrug efflux pumps of Gram-negative bacteria. J Bacteriol 178, 5853-5859 (1996).
48. Paulsen, I. T., Brown, M. H., Skurray, R. A.: Proton-dependent multidrug efflux systems. Microbiol Rev 60, 575-608 (1996).
49. van Veen, H. W., Callaghan, R., Soceneantu, L., Sardini, A., Konigs, W. N., Higgins, C. F.: A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391, 291-295 (1998).
50. Paulsen, I. T., Skurray, R. A., Tam, R., Saier, M. H., Turner, Jr. R. J., Weiner, J. H., Goldberg, E. B., Grinius, L. L.: The SMR family: A novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol Microbiol 19, 1167-1175 (1996).
51. Brown, M. H., Paulsen, I. T., Skuarry, R. A.: The multidrug efflux protein NorM is a prototype of a new family of transporters. Mol Microbiol 31, 394-395 (1999).
52. Saier, M. H., Tam, Jr. R., Reizer, A., Reizer, J.: Two novel families of bacterial membrane proteins concerned with nodulation, cell division and transport. Mol Microbiol 11, 841-847 (1994).
53. Molnár, J., Domonkos, K., Mándi, Y., Földeák, S., Holland, I. B.: The possible mechanism of plasmid elimination by phenothiazines and related drugs. In: Phenothiazines and Structurally Related Drugs, Basic and Clinical Studies, Usdin, Eckert, Forrest (eds), Elsevier North Holland Inc., 115-116 (1980).
54. Rosenberg, E. Y., Ma, D., Nikaido, H.: AcrD of Escherichia coli is aminoglycoside efflux pump. J Bacteriol 182, 1754-1756 (2000).
55. Baranova, N., Neyfakh, A.: Apparent involvement of a multidrug transporter in the fluoroquinolone resistance of Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 41, 1396-1398 (1997).