Ciprofloxacin at low levels disrupts colonization resistance of human fecal microflora growing in chemostats

Regulatory Toxicology and Pharmacology

Volumn 40, Issue 3, 2004, Pages 319-326

  Carman, Robert J ^a   Simon, Mary Alice ^a   Fernández, Haydée ^b   Miller, Margaret A ^b   Bartholomew, Mary J ^b  

^a TECHLAB INC   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Antibiotic; Antimicrobial; Barrier effect; Chemostat; Competitive exclusion; Feces; Fluoroquinolone; Intestinal; Nurmi effect; Residue

Indexed keywords

CIPROFLOXACIN;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL STRAIN; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; ESCHERICHIA COLI; FECES MICROFLORA; IN VITRO STUDY; INTESTINE FLORA; NONHUMAN; PRIORITY JOURNAL; SALMONELLA; SALMONELLA KADOGOU;

ANTI-INFECTIVE AGENTS; BACTERIA; BACTEROIDES; BIOLOGICAL ASSAY; CIPROFLOXACIN; COLONY COUNT, MICROBIAL; ESCHERICHIA COLI; FECES; HUMANS; MODELS, BIOLOGICAL; SALMONELLA; TIME FACTORS;

ESCHERICHIA COLI; SALMONELLA;

EID: 8844234323     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yrtph.2004.08.005     Document Type: Article

References (54)

1. A. Beneni, and E.B. Minelli Effects of immnosuppression and antimicrobial prophylaxis on rat intestinal microflora Microecol. Ther. 25 1995 46 53
2. T. Bergan, C. Delin, S. Johansen, I.M. Kolstad, C.E. Nord, and S.B. Thorsteinsson Pharmacokinetics of ciprofloxacin and effect of repeated dosage on salivary and fecal microflora Antimicrob. Agents Chemother. 29 1986 298 302
3. H. Bernhardt, K. Schulz, K. Zimmermann, and M. Knoke Influence of ciprofloxacin and other antimicrobial drugs on different Escherichia coli strains in continuous-flow cultures under aerobic and anaerobic conditions J. Antimicrob. Chemother. 42 1998 147 152
4. M. Borzio, F. Salerno, M. Saudelli, D. Galvagno, L. Piantoni, and L. Fragiacomo Efficacy of oral ciprofloxacin as selective intestinal decontamination in cirrhosis Ital. J. Gastroenterol. Heptal. 29 1997 262 266
5. B. Brismar, C. Edlund, A.-S. Malmborg, and C.E. Nord Ciprofloxacin concentrations and impact of the colon microflora on patients undergoing colorectal surgery Antimicrob. Agents Chemother. 34 1990 481 483
6. J.-M. Brogard, F. Jehl, H. Monteil, M. Adloff, J.-F. Blickle, and P. Levy Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humans Antimicrob. Agents Chemother. 28 1985 311 314
7. W. Brumfitt, I. Franklin, D. Grady, J.M.T. Hamilton-Miller, and A. Iliffe Changes in the pharmacokenetics of ciprofloxacin and fecal flora during administration of a 7-day course to human volunteers Antimicrob. Agents Chemother. 26 1984 757 761
8. R.J. Carman, and M.A. Woodburn Effects of low levels of ciprofloxacin on a chemostat model of the human colonic microflora Reg. Pharmacol. Toxicol. 33 2001 276 284
9. H.H. Collins, A.S. Croos, A. Dobek, S.M. Opal, J.B. McClain, and J.C. Sadoff Oral ciprofloxacin and a monoclonal antibody to lipopolysaccharide protect leukopenic rats from lethal infection with Pseudomonas aeruginosa J. Infect. Dis. 159 1989 1073 1082
10. T.D. Crabtree, S.J. Pelletier, T.G. Gleason, T.L. Pruett, and R.G. Sawyer Clinical characteristics and antibiotic utilization in surgical patients with Clostridium difficile-associated diarrhea Am. Surg. 65 1999 507 511
11. A.A. Delsol, J. Sunderland, M.J. Woodward, L. Pumbwe, L.J. Piddock, and J.M. Roe Emergence of fluoroquinolone resistance in the native Campylobacter coli population of pigs exposed to enrofloxacin J. Antimicrob. Chemother. 53 2004 872 874
12. R. Enzensberger, P.M. Shah, and H. Knothe Impact of oral ciprofloxacin on the faecal flora of healthy volunteers Infection 13 1985 273 275
13. S. Esposito, D. Barba, D. Galante, G.B. Gaeta, and O. Lagheeza Intestinal microflora changes induced by ciprofloxacin and treatment of portal systemic encephalopathy (PSE) Drugs Exp. Clin. Res. 13 1987 641 646
14. S. Esposito, D. Galante, D. Barba, G. D'Errico, A. Mazzone, and S. Montanaro Ciprofloxacin concentrations in human fluids and tissues after a single oral dose Int. J. Clin. Pharmacol. Res. 7 1987 181 186
15. FDA, 2002. Code of Federal Regulations. Title 21. Chapter I. Food and Drug Administration, Department of Health and Human Services, Part 556.228. Enrofloxacin, 04-01-02 ed. Office of the Federal Register, National Archives and Records Administration, p. 342
16. G. Garcia-Calvo, A. Molleja, M.J. Gimenez, A. Parra, E. Nieto, C. Ponte, L. Aguilar, and F. Soriano Effects of single oral doses of gemifloxacin (320 milligrams) versus trovafloxacin (200 milligrams) on fecal flora in healthy volunteers Antimicrob. Agents Chemother. 45 2001 608 611
17. M.R. Gismondo, L. Drago, A. Lombardi, C. Fassina, and M. Cesana Impact of rufloxacin and ciprofloxacin on the intestinal microflora in a germ-free mice model Chemotherapy 41 1995 281 288
18. L.J. Goodman, R.A. Kaplan, R.M. Petrak, R.B. Fliegelman, D. Taff, F. Walton, J.L. Penner, and G.M. Trenholme Effects of erythromycin and ciprofloxacin on chronic fecal excretion of Campylobacter species in marmosets Antimicrob. Agents Chemother. 1986 29,185 187
19. C. Guerin-Danan, C. Andrieux, and O. Szylit Storage of intestinal bacteria in samples frozen with glycerol Microb. Ecol. Hlth. Dis. 11 1999 180 182
20. L.V. Holdeman, E.P. Cato, and W.E.C. Moore Anaerobe Lab Manual fourth ed. 1977 Anaerobe Laboratory, Virginia Polytechnic Institute and State University Blacksburg, VA pp.134-148
21. H.A. Holt, D.A. Lewis, L.O. White, S.Y. Bastable, and D.S. Reeves Effect of oral ciprofloxacin on the faecal flora of healthy volunteers Eur. J. Clin. Microbiol. 5 1986 201 205
22. N. Janin, H. Meugnier, J.F. Desnottes, R. Woehrle, and J. Fleurette Recovery of perfloxacin in saliva and feces and its action on oral and fecal floras of healthy volunteers Antimicrob. Agents Chemother. 31 1987 1665 1668
23. F. Jehl, M. Adloff, H. Monteil, and J.M. Brogard Ciprofloxacin biliary disposition in cholecystectomised patients with special reference to HPLC and bioassay data Eur. J. Drug. Metab. Pharmacokinet. 12 1987 115 122
24. W.A. Krueger, G. Ruckdeschel, and K. Unertl Influence of intravenously administered ciprofloxacin on aerobic intestinal microflora and fecal drug levels when administered with sucralfate Antimicrob. Agents Chemother. 41 1997 1725 1730
25. W.A. Krueger, G. Ruckdeschel, and K. Unertl Elimination of fecal Enterobacteriaceae by intravenous ciprofloxacin is not inhibited by concomitant sucralfate-a microbiological and pharmacokinetic study in patients Infection 27 1999 335 340
26. K.K. Lai, Z.S. Melvin, M.J. Menard, H.R. Kotilainen, and S. Baker Clostridium difficile-associated diarrhea: epidemiology, risk factors, and infection control Infect. Control Hosp. Epidemiol. 18 1997 628 632
27. D.A. Leigh, B. Walsh, K. Harris, P. Hancock, and G. Travers Pharmacokinetics of ofloxacin and the effects on the faecal flora of healthy volunteers J. Antimicrob. Chemother. 22 Suppl. C 1988 115 125
28. C.-X. Liu, N. Kato, K. Watanabe, T. Sakata, and T. Kaneko Impact of a new quinolone, DU-6859a, and two oral carbapenems, CS-834 and L-084, on the rat and mouse caecal microflora J. Antimicrob. Chemother. 46 2000 823 826
29. B. Ljungberg, I. Nilsson-Ehle, C. Edlund, and C.E. Nord Influence of ciprofloxacin on the colonic microflora in young and elderly volunteers: no impact of altered drug absorption Scand. J. Infect. Dis. 22 1990 205 208
30. G.J. Maijer-Severs, E. van Santen, and H.G. de Vries-Hospers Low-dose ciprofloxacin for selective decontamination of the digestive tract in human volunteers Eur. J. Clin. Microbiol. Infect. Dis. 9 1990 285 287
31. M.L. McConville, J.W. Dijkstra, J.J.M. van Saene, and J.F.M. Nouws Effects of sarafloxacin hydrochloride on human enteric bacteria under simulated human gut conditions Vet. Quart. 17 1995 1 5
32. M.E. McCusker, A.D. Harris, E. Perencevich, and M.-C. Roghmann Fluoroquinolone use and Clostridium difficile-associated diarrhea Emerg. Infect. Dis. 9 2003 730 733
33. G.C. Mead, P.A. Barrow, M.H. Hinton, F. Humbert, C.S. Impey, C. LeHellec, R.W.A.W. Mulder, S. Stavric, and N.J. Stern Recommended assay for treatment of chicks to prevent Salmonella colonization by "competitive exclusion" J Food Prot. 52 1989 500 502
34. NCCLS, 1993. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, third ed. Approved Standard. Document M7-A3. NCCLS, Villanova, PA, 32pp
35. T. Nosova, K. Jokelainen, P. Kaihovaara, Vak̈evaïnen, M. Rautio, H. Jousimies-Somer, and M. Salaspuro Ciprofloxacin administration decreases enhanced ethanol elimination in ethanol-fed rats Alcohol Alcoholism 34 1999 48 54
36. L. Nuotio, and G.C. Mead An in vitro model for studies on bacterial interactions in the avian caecum Lett. Appl. Microbiol. 17 1993 65 67
37. S. Pecquet, A. Andremont, and C. Tancrede Selective antimicrobial modulation of the intestinal tract by norfloxacin in human volunteers and in gnotobiotic mice associated with fecal flora Antimicrob. Agents Chemother. 29 1986 1047 1052
38. S. Pecquet, A. Andremont, and C. Tancrede Effect of oral ofloxacin on fecal bacteria in healthy volunteers Antimicrob. Agents Chemother. 31 1987 124 125
39. S. Pecquet, S. Ravoire, and A. Andremont Faecal excretion of ciprofloxacin after a single oral dose and its effect on faecal bacteria in healthy volunteers J. Antimicrob. Chemother. 26 1990 125 129
40. R. Peltonen, and E. Eerola Direct automatic analysis of rat stool samples; the effect of diet and medical treatment studied by computerised gas-liquid chromatography of bacterial fatty acids Microb. Ecol. Hlth. Dis. 5 1992 93 103
41. J. Ramon, S. Dautrey, R. Farinoti, C. Carbon, and E. Rubinstein Intestinal elimination of ciprofloxacin in rabbits Antimicrob. Agents Chemother. 38 1994 757 760
42. J. Ramon, S. Dautrey, R. Farinoti, C. Carbon, and E. Rubinstein Excretion of ciprofloxacin into the large bowel of the rabbit Antimicrob. Agents Chemother. 40 1996 11 13
43. M. Ritz, H. Lodfe, M. Fabender, K. Borner, P. Koeppe, and C.E. Nord Multiple-dose pharmacokinetics of sparfloxacin and its influence on fecal flora Antimicrob. Agents Chemother. 38 1994 455 459
44. M. Rozenberg-Arska, A.W. Dekker, and J. Verhoef Ciprofloxacin for selective decontamination of the alimentary tract in patients with acute leukemia during remission induction treatment: the effect on fecal flora J. Infect. Dis. 152 1985 104 107
45. M. Steinbakk, E. Lingaas, B. Carlstedt-Duke, T. Høverstad, A.C. Midvedt, K.E. Norin, and T. Midtvedt Faecal concentration of ten antibiotics and microflora-associated microflora-associated characteristics (MACs) Microb. Ecol. Hlth. Dis. 5 1992 269 272
46. R. Terg, K. Llano, S.M. Cobas, C. Brotto, A. Barrios, D. Levi, W. Wasen, and M.A. Bartellini Effects of oral ciprofloxacin on aerobic gram-negative fecal flora in patients with cirrhosis: results of short- and long-term administration with daily and weekly dosages J. Hepatol. 29 1998 437 442
47. J. Tillonen, N. Homann, M. Rautio, H. Jousimies-Somer, and M. Salaspuro Ciprofloxacin decreases the rate of ethanol elimination in humans Gut 44 1999 347 352
48. J.J. van de Leur, E.J. Vollard, A.J. Janssen, and A.S. Dofferhoff Influence of low dose ciprofloxacin on microbial colonization of the digestive tract in healthy volunteers during normal and during impaired colonization resistance Scand. J. Infect. Dis. 29 1997 297 300
49. H.K.F. van Saene, S.E.B. Lemmens, and J.J.M. van Saene Gut decontamination by oral ofloxacin and ciprofloxacin in healthy volunteers J. Antimicrob. Chemother. 22 Suppl. C 1988 127 134
50. WHO, 1995. Toxicological evaluation of certain veterinary drug residues in food. Enrofloxacin. WHO Food Additives Series, vol. 34. World Health Organization, Geneva, Switzerland, pp. 61-84
51. K.H. Wilson, and F. Perini Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora Infect Immun. 56 1988 2610 2614
52. J. Wistrom, L.O. Gentry, A.-C. Palmgren, M. Price, C.E. Nord, A.A. Ljungh, and S.R. Norrby Ecological effects of short-term ciprofloxacin treatment of travellers' diarrhea J. Antimicrob. Chemother. 30 1992 693 706
53. C. Wiuff, J. Lykkesfeldt, F.M. Aarestruop, and Svensden Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations J. Vet. Pharmacol. Ther. 25 2002 335 342
54. C. Yip, M. Loeb, S. Salama, L. Moss, and J. Olde Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea Infect. Control Hosp. Epidemiol. 22 2001 572 575