The integrity of cholesterol-enriched microdomains is essential for the constitutive high activity of protein kinase B in tumour cells

Biochemical Society Transactions

Volumn 32, Issue 5, 2004, Pages 837-839

  Elhyany, S ^a   Assa Kunik, E ^b   Tsory, S ^a   Muller, T ^a   Fedida, S ^a   Segal, S ^a   Fishman, D ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Cholesterol enriched microdomain; Lipid raft; Major histocompalibilily complex (MHC); Protein kinase B

Indexed keywords

ANTINEOPLASTIC AGENT; CHOLESTEROL; GLYCOPROTEIN; H2 K CLASS 1 GLYCOPROTEIN; HEAT SHOCK PROTEIN 90; HYPOCHOLESTEROLEMIC AGENT; LIPID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PHOSPHATASE; PROTEIN KINASE B; PROTEIN SERINE THEONINE PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; SERINE; THREONINE; UNCLASSIFIED DRUG;

APOPTOSIS; CHOLESTEROL ENRICHED MICRODOMAIN; CONFERENCE PAPER; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; LIPID MEMBRANE; LIPID RAFT; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; CHOLESTEROL; GLYCOPROTEINS; HSP90 HEAT-SHOCK PROTEINS; MELANOMA, EXPERIMENTAL; MEMBRANE MICRODOMAINS; MICE; NEOPLASMS; NOVOBIOCIN; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 8744294003     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0320837     Document Type: Conference Paper

References (10)

1. Brader, S. and Eccles, S.A. (2004) Tumori 90, 2-8
2. Zhuang, L., Lin, J., Lu, M.L., Solomon, III, K.R. and Freeman, M. (2002) Cancer Res. 62, 2227-2231
3. Brown, D.A. and London, E. (1998) Annu. Rev. Cell Dev. Biol. 14, 111-136
4. Assa-Kunik, E., Fishman, D., Kellman-Pressman, S., Tsory, S., Elhyany, S., Bahatir, O. and Segal, S. (2003) J. Immunol. 171, 2945-2952
5. Fishman, D., Elhyany, S. and Segal, S. (2004) Folia Biol. (Praha) 50, 35-42
6. Stagsted, J. (1998) APMIS Suppl. 85, 1-40
7. Gorelik, E., Kim, M., Duty, L., Henion, T. and Galili, U. (1993) Clin. Exp. Metastasis 11, 439-452
8. Resjo, S., Goransson, D., Harndahl, L., Zolnierowicz, S., Manganiello, V. and Degerman, E. (2002) Cell Signal. 14, 231-238
9. Sehgal, P.B. (2003) Acta Biochim. Pol. 50, 583-594
10. Damjanovich, S., Matyus, L., Damjanovich, L., Bene, L., Jenei, A., Matko, J., Gaspar, R. and Szollosi, J. (2002) Immunol. Lett 82, 93-99