Attentional facilitation of response is impaired for antisaccades but not for saccades in patients with schizophrenia: Implications for cortical dysfunction

Experimental Brain Research

Volumn 159, Issue 1, 2004, Pages 47-54

  Smyrnis, Nikolaos ^a,b   Malogiannis, Ioannis A ^a,c   Evdokimidis, Ioannis ^a   Stefanis, Nicholas C ^b   Theleritis, Christos ^a   Vaidakis, Alexandros ^c   Theodoropoulou, Stavroula ^c   Stefanis, Costas N ^b  

^a NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY MENTAL HEALTH RESEARCH INSTITUTE   (Greece)

^c IASO GENERAL HOSPITAL   (Greece)

Author keywords

Deficit syndrome; Gap effect; Inhibition; Oculomotor; Response latency; Spatial attention

Indexed keywords

ADULT; ARTICLE; BRAIN DYSFUNCTION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FACILITATION; FEMALE; HUMAN; LATENT PERIOD; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SCHIZOPHRENIA; TASK PERFORMANCE; VISION;

ADULT; ATTENTION; CEREBRAL CORTEX; FEMALE; HUMANS; MALE; PHOTIC STIMULATION; REACTION TIME; SACCADES; SCHIZOPHRENIA; STATISTICS, NONPARAMETRIC;

EID: 8744260584     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-004-1931-0     Document Type: Article

References (38)

1. American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Press, Washington, DC
2. Carpender WT Jr, Heinrichs DW, Wagman AMI (1988) Deficit and non-deficit forms of schizophrenia, the concept. Am J Psychiatry 145:578-583
3. Clementz BA, McDowell JE Jisook S (1994) Saccadic system functioning among schizophrenia patients and their first-degree relatives. J Abnorm Psychol 103:277-287
4. Comblatt BA, Keilp JG (1994) Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 20:31-46
5. Curtis CE, Calkins ME, Grove WM, Feil KJ, Iacono WG (2001) Saccadic disinhibition in patients with acute and remitted schizophrenia and their first degree relatives. Am J Psychiatry 158:100-106
6. Dorris MC, Munoz DP (1995) A neural correlate for the gap effect on saccadic reaction times in monkey. J Neurophysiol 73:2558-2562
7. Evdokimidis I, Smyrnis N, Constantinidis TS, Stefanis NC, AvramopoulosD, Paximadis C, Theleritis C, Efstratiadis C, KastrinakisG, Stefanis CN (2002) The antisaccade task in a sample of 2,006 young males. I. Normal population characteristics. Exp Brain Res 147:45-52
8. Everling S, Munoz DP (2000) Neuronal correlates for preparatory set associated with pro-saccades and anti-saccades in the primate frontal eye field. J Neurosci 20:387-400
9. Everling S, Dorris MC, Klein RM, Munoz DP (1999) Role of primate superior colliculus in preparation and execution of antisaccades and pro-saccades. J Neurosci 19:2740-2754
10. Fischer B, Weber H (1992) Characteristics of antisaccade in man. Exp Brian Res 89:415-424
11. Fischer B, Weber H (1993) Express saccades and visual attention. Behav Brain Sci 16:553-610
12. Fischer B, Weber H (1997) Effects of stimulus conditions on the performance of antisaccades in man. Exp Brain Res 116:191-200
13. Fukushima J, Fukushima K, Chiba T, Tanaka S, Yamashita I, Kato M (1988) Disturbances of voluntary control of saccadic eye movements in schizophrenic patients. Biol Psychiatry 23:670-677
14. Fukushima J, Morita N, Fukushima K, Chiba T, Tanaka S, Yamashita I (1990) Voluntary control of saccadic eye movements in patients with schizophrenic and affective disorders. J Psychiatr Res 24:9-24
15. Funahashi S, Chafee MV, Goldman-Rakic PS (1993) Prefrontal neuronal activity in Rhesus monkeys performing a delayed antisaccade task. Nature 365:753-756
16. Guitton D, Buchtel HA, Douglas RM (1985) Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Exp Brain Res 58:455-472
17. Katsanis J, Kortenkamp S, Iacono WG, Grove WM (1997) Antisaccade performance in patients with schizophrenia and affective disorder. J Abnorm Psychol 106:468-472
18. Kirkpatrick B, Buchanan RW, Mckenney PD, Alphs LD, Carpender WT Jr (1989) The schedule for the deficit syndrome, an instrument for research in schizophrenia. Psychiatry Res 30:119-123
19. Klein RM, Kingstone A (1993) Why do visual offsets reduce saccadic latencies? Behav Brain Sci 16:583-584
20. McDowell JE, Clementz BA (1997) The effect of fixation condition manipulations on antisaccade performance in schizophrenia, studies of diagnostic specificity. Exp Brain Res 115:333-344
21. McDowell JE, Clementz BA (2001) Behavioral and brain imaging studies of saccadic performance in schizophrenia. Biol Psychol 57:5-22
22. McDowell JE, Brown GG, Paulus M, Martinez A, Stewart SE, Dubowitz DJ, Braff DL (2002) Neural correlates of refixation saccades and antisaccades in normal and schizophrenic subjects. Biol Psychiatry 51:216-223
23. Nestor PG, Faux SF, McCarley RW, Penhune V, Shenton ME, Pollak S (1992) Attentional cues in chronic schizophrenia, abnormal disengagement of attention. J Abnorm Psychol 101:682-689
24. Nuechterlein KH, Dawson M (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schiz Bull 10:160-203
25. O'Driscoll GA, Alpert NM, Matthysse SW, Levy DL, Rauch SL, Holzman PS (1995) Functional neuroanatomy of antisaccade eye movements investigated with positron emission tomography. Proc Natl Acad Sci U S A 92:925-929
26. Posner MI, Early TS, Reiman E, Pardo PJ, Dhawan M (1988) Asymmetries in hemispheric control of attention in schizophrenia. Arch Gen Psychyiatry 45:814-821
27. Reuter-Lorenz PA, Hughes HC, Fendrich R (1991) The reduction of saccadic latency by prior fixation point offset, an analysis of the gap effect. Percept Psychophys 49:167-175
28. Reuter-Lorenz PA, Oonk HM, Barnes LL, Hughes HC (1995) Effects of warning signals and fixation point offsets on the latencies of pro- versus antisaccades, implications for an interpretation of the gap effect. Exp Brain Res 103:287-293
29. Ross DE, Thaker GK, Buchanan RW, Kirkpatrick B, Lahti AC, Medoff D, Bartko JJ, Goodman J, Tien A (1997) Eye tracking disorder in schizophrenia is characterized by specific ocular motor defects and is associated with the deficit syndrome. Biol Psychiatry 42:781-796
30. Schlag-Rey M, Amador N, Sanchez H, Schlag J (1997) Antisaccade performance predicted by neuronal activity in the supplementary eye field. Nature 390:398-401
31. Sereno AB, Holzman PS (1995) Antisaccades and smooth pursuit eye movements in schizophrenia. Biol Psychiatry 37:394-401
32. Sheehan DV, Lecroubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al (1998) The Mini International Neuropsychiatrie Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM IV and ICD 10. J Clin Psychiatry 59:22-33
33. Smyrnis N, Evdokimidis I, Stefanis NC, Constantinidis TS, AvramopoulosD, Theleritis C, Paximadis C, Efstratiadis C, KastrinakisG, Stefanis CN (2002) The antisaccade task in a sample of 2,006 young males. II. Effect of task parameters. Exp Brain Res 147:53-63
34. Sweeney JA, Mintun MA, Kwee S (1996) Positron emission tomography study of voluntary saccadic eye movements and spatial working memory. J Neurophysiol 75:454-468
35. Thaker G, Kirkpatrick B, Buchanan RW, Ellsberry R, Tamminga C (1989) Oculomotor abnormalities and their clinical correlates in schizophrenia. Psychopharmacol Bull 25:491-497
36. Tien AY, Ross DE, Pearlson G, Strauss ME (1996) Eye movements and psychopathology in schizophrenia and bipolar disorder. J Nerv Ment Dis 184:331-338
37. Weinberger DR (1988) Schizophrenia and the frontal lobe. Trends Neurosci 11:367-370
38. Zhang M, Barash S (2000) Neuronal switching of sensorimotor transformations for antisaccades. Nature 408:971-975