Effectiveness of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid laminin-5 γ2 chain levels in chronic periodontitis

Journal of Periodontology

Volumn 75, Issue 10, 2004, Pages 1387-1396

  Emingil, Gülnur ^a   Atilla, Gül ^a   Sorsa, Timo ^b   Savolainen, Pirjo ^b   Baylas, Haluk ^a  

^a EGE UNIVERSITY   (Turkey)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Adjunctive therapy; Cells, epithelial; Clinical trials, randomized; Comparison studies; Double blind method; Doxycycline therapeutic use; Gingival crevicular fluid analysis; Laminin; Metalloproteinases, matrix; Periodontal diseases therapy; Planing; Scaling

Indexed keywords

ANTIBODY; DOXYCYCLINE; LAMININ; MATRIX METALLOPROTEINASE; PLACEBO; PROTEIN SUBUNIT;

ADULT; ARTICLE; CELL MIGRATION; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EPITHELIUM CELL; FEMALE; FRIEDMAN TEST; HUMAN; IMAGE ANALYSIS; IMMUNE RESPONSE; LOW DRUG DOSE; MALE; PARALLEL DESIGN; PERIODONTITIS; PREVENTIVE DENTISTRY; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TOOTH PLAQUE; WESTERN BLOTTING;

ADULT; ANTI-BACTERIAL AGENTS; CHRONIC DISEASE; COMBINED MODALITY THERAPY; DENTAL PLAQUE INDEX; DENTAL SCALING; DOUBLE-BLIND METHOD; DOXYCYCLINE; FEMALE; FOLLOW-UP STUDIES; GINGIVAL CREVICULAR FLUID; HUMANS; LAMININ; MALE; MIDDLE AGED; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PERIODONTAL POCKET; PERIODONTITIS; PLACEBOS; ROOT PLANING;

EID: 8744255569     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2004.75.10.1387     Document Type: Article

References (51)

1. Listgarten MA. Nature of periodontal diseases: Pathogenic mechanisms. J Periodontal Res 1987;22:172-178.
2. Birkedal-Hansen R. Role of cytokines and inflammatory mediators in tissue destruction. J Periodontal Res 1993;28: 500-510.
3. Pöllänen MT, Salonen JI, Uitto VJ. Structure and function of the tooth-epithelial interface in health and disease. Periodontology 2000 2003;31:12-31.
4. Colognato H, Yurchenco PD. Form and function: The laminin family of heterotrimers. Dev Dyn 2000;218:213-234.
5. O'Toole EA. Extracellular matrix and keratinocyte migration. Clin Exp Dermatol 2001;26:525-530.
6. Terranova VP, Lyall RM. Chemotaxis of human gingival epithelial cells to laminin. A mechanism for epithelial cell apical migration. J Periodontol 1986;57:311-317.
7. Gürses N, Thorup AK, Reibel J, Carter GW, Holmstrup P. Expression of VLA-integrins and their related basement membrane ligands in gingiva from patients of various periodontitis categories. J Clin Periodontol 1999;26: 217-224.
8. Hormia M, Sahlberg C, Thesleff I, Airenne T. The epithelium-tooth interface - a basal lamina rich in laminin-5 and lacking other known laminin isoforms. J Dent Res 1998;77: 1479-1485.
9. O'Toole EA, Marinkovich MP, Hoeffler WK, Furthmayr H, Woodley DT. Laminin-5 inhibits human keratinoyte migration. Exp Cell Res 1997;233:330-339.
10. Gagnoux-Palacios L, Allergra M, Spirito F, et al. The short arm of the laminin γ2 chain plays a pivotal role in the incorporation of laminin 5 into the extracellular matrix and in cell adhesion. J Cell Biol 2001;153:835-849.
11. Giannelli G, Falk-Marzillier J, Schiraldi O, Stetler-Stevenson WG, Quaranta V. Induction of cell migration by matrix metalloproteinase-2 cleavage of laminin-5. Science 1997; 277:225-228.
12. Heck LW, Blackburn WD, Irwin MH, Abrahamson DR. Degradation of basement membrane laminin by human neutrophil elastase and cathepsin G. Am J Pathol 1990;136: 1267-1274.
13. Mäkelä M, Larjava H, Pirilä E, et al. Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes. Exp Cell Res 1999;251:67-78.
14. Pirilä E, Maisi P, Salo T, Koivunen E, Sorsa T. In vivo localization of gelatinases (MMP-2 and -9) by in situ zymography with a selective gelatinase. Biochem Biophys Res Commun 2001;287:766-774.
15. Pirilä E, Sharabi A, Salo T, et al. Matrix metalloproteinases process the laminin-5 γ2-chain and regulate epithelial cell migration. Biochem Biophys Res Commun 2003;303: 1012-1017.
16. Kivela-Rajamaki MJ, Teronen OP, Maisi P, et al. Laminin-5 γ2-chain and collagenase-2 (MMP-8) in human peri-implant sulcular fluid. Clin Oral Implants Res 2003;14: 158-165.
17. Loesche WJ. The antimicrobial treatment of periodontal disease: Changing the treatment paradigm. Crit Rev Oral Biol Med 1999;10:245-275.
18. Golub LM, Wolff M, Lee HM, et al. Further evidence that tetracyclines inhibit collagenase activity in human crevicular fluid and from other mammalian sources. J Periodontal Res 1985;20:12-23.
19. Golub LM, McNamara TF, D'Angelo G, Greenwald RA, Ramamurthy NS. A non-antibacterial chemically-modified tetracycline inhibits mammalian collagenase activity. J Dent Res 1987;66:1310-1314.
20. Golub LM, Ciancio S, Ramamurthy NS, Leung M, McNamara TF. Low-dose doxycycline therapy: Effect on gingival and crevicular fluid collagenase activity in humans. J Periodontal Res 1990;25:321-330.
21. Golub LM, Wolff M, Roberts S, Lee HM, Leung M, Payonk GS. Treating periodontal diseases by blocking tissue-destructive enzymes. J Am Dent Assoc 1994;125: 163-171.
22. Golub LM, Evans RT, McNamara TF, Lee HM, Ramamurthy NS. A non-antimicrobial tetracycline inhibits gingival matrix metalloproteinases and bone loss in Porphyromonas gingivalis induced periodontitis in rats. Ann NY Acad Sci 1994;732:96-111.
23. Caton JG. Evaluation of Periostat for patient management. Compend Contin Educ Dent 1999;20:451-463.
24. Crout RJ, Lee HM, Schroeder K, et al. The "cyclic" regimen of low-dose doxycycline for adult periodontitis: A preliminary study. J Periodontol 1996;67:506-514.
25. Golub LM, Lee HM, Greenwald RA, et al. A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res 1997; 46:310-319.
26. Ciancio S, Ashley R. Safety and efficacy of sub-antimicrobial-dose doxycycline therapy in patients with adult periodontitis. Adv Dent Res 1998;12:27-31.
27. Caton JG, Ciancio SG, Blieden TM, et al. Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol 2000;71:521-532.
28. Golub LM, McNamara TF, Ryan ME, et al. Adjunctive treatment with subantimicrobial doses of doxcycline: Effects on gingival fluid collagenase activity and attachment loss in adult periodontitis. J Clin Periodontol 2001;28:146-156.
29. Caton JG, Ciancio SG, Blieden TM, et al. Subantimicrobial dose doxycycline as an adjunct to scaling and root planing: Post-treatment effects. J Clin Periodontol 2001;28:782-789.
30. Novak MJ, Johns LP, Miller RC, Bradshaw MH. Adjunctive benefits of subantimicrobial dose doxycycline in the management of severe, generalized, chronic periodontitis. J Periodontol 2002;73:762-769.
31. Thomas JG, Metheny RJ, Karakiozis JM, Wetzel JM, Crout RJ. Long-term sub-antimicrobial doxycycline (Periostat) as adjunctive management in adult periodontitis: Effects on subgingival bacterial population dynamics. Adv Dent Res 1998;12:32-39.
32. Walker C, Thomas J, Nango S, Lennon J, Wetzel J, Powala C. Long-term treatment with subantimicrobial dose doxycycline exerts no antibacterial effect on the subgingival microflora associated with adult periodontitis. J Periodontol 2000;71:1465-1471.
33. Thomas J, Walker C, Bradshaw M. Long-term use of subantimicrobial dose doxycycline does not lead to changes in antimicrobial susceptibility. J Periodontol 2000;71: 1472-1483.
34. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-7.
35. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21: 532-551.
36. Turesky S, Gilmore ND, Glickman I. Reduced plaque formation by the chloromethyl analogue of vitamin C. J Periodontol 1970;41:41-43.
37. Lamster IB, Hartley LJ, Oshrain RL. Evaluation and modification of spectrophotometric procedures for analysis of lactate dehydrogenase, beta-glucuronidase and arylsulphatase in human gingival crevicular fluid collected with filter-paper strips. Arch Oral Biol 1985;30: 235-242.
38. Cimasoni G. Method of collection. Crevicular Fluid Updated Basel: S. Karger; 1983;29-36.
39. Greenstein G. Periodontal response to mechanical nonsurgical therapy: A review. J Periodontol 1992;63:118-130.
40. Socransky SS, Haffajee AD. Effect of therapy on periodontal infections. J Periodontol 1993;64:754-759.
41. The American Academy of Periodontology. Parameter on periodontal maintenance. J Periodontol 2000;71: 849-850.
42. Greenstein G, Lamster IB. Efficacy of subantimicrobial dosing with doxycycline. Point/counterpoint. J Am Dent Assoc 2001;132:457-465.
43. Killoy WJ. The use of locally-delivered chlorhexidine in the treatment of periodontitis. Clinical results. J Clin Periodontol 1998;25:953-958.
44. Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, Sorsa T. Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 1998;12:12-26.
45. Golub LM, Ramamurthy NS, McNamara TF. Tetracyclines inhibit connective tissue breakdown: New therapeutic implications for an old family of drugs. Crit Rev Oral Biol Med 1991;2:297-322.
46. Golub LM, Suomalainen K, Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent 1992;2:80-90.
47. Figueredo CMS, Gustafsson A. Increased amounts of laminin in GCF from untreated patients with periodontitis. J Clin Periodontol 2000;27:313-318.
48. Demirel K, Baer PN, McNamara TF. Topical application of doxycycline on periodontally involved root surfaces in vitro: Comparative analysis of substantivity on cementum and dentin. J Periodontol 1991;62:312-316.
49. Michalowicz BS, Pihlstrom BL, Drisko CL, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers: Maintenance response. J Periodontol 1995;66: 708-715.
50. Pirilä E, Parikka M, Ramamurthy NS, et al. Chemically modified tetracycline (CMT-8) and estrogen promote wound healing in ovariectomized rats: Effects on matrix metalloproteinase-2, membrane type 1 matrix metalloproteinase, and laminin-5 γ2-chain. Wound Rep Reg 2002; 10:38-51.
51. Emingil G, Atilla G, Sorsa T, Luoto H, Kirilmaz L, Baylas H. The effect of adjunctive low-dose doxyccline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic adult periodontitis. J Periodontol 2004;75:106-115.