Divergent action potential morphologies reveal nonequilibrium properties of human cardiac Na channels

Cardiovascular Research

Volumn 64, Issue 3, 2004, Pages 477-487

  Magyar, János ^a   Kiper, Carmen E ^a   Dumaine, Robert ^b   Burgess, Don E ^a   Bányász, Tamás ^c   Satin, Jonathan ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Gene expression; Human stem cell; Long Q T syndrome; Na channel

Indexed keywords

VOLTAGE GATED SODIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; COMPARATIVE STUDY; ENDOCARDIUM; EPICARDIUM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; SODIUM CURRENT; SODIUM TRANSPORT; VOLTAGE CLAMP; WILD TYPE;

ACTION POTENTIALS; ANIMALS; CELLS, CULTURED; DOGS; ELECTRIC STIMULATION; HUMANS; KIDNEY; LONG QT SYNDROME; MUTATION; MYOCYTES, CARDIAC; SODIUM CHANNELS; STEM CELLS;

EID: 8644291539     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.07.014     Document Type: Article

References (24)

1. Y.M. Liu, L.J. DeFelice, and M. Mazzanti Na channels that remain open throughout the cardiac action potential plateau Biophys. J. 63 1992 654 662
2. J.B. Patlak, and M. Ortiz Slow currents through single sodium channels of the adult rat heart J. Gen. Physiol. 86 1985 89 104
3. Y.I. Zilberter, C.F. Starmer, J. Starobin, and A.O. Grant Late Na channels in cardiac cells: the physiological role of background Na channels Biophys. J. 67 1994 153 160
4. L. Conforti, N. Tohse, and N. Sperelakis Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytes-contribution to the plateau phase of action potential J. Mol. Cell. Cardiol. 25 1993 159 173
5. T. Kiyosue, and M. Arita Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes Circ. Res. 64 1989 389 397
6. J.A. Wasserstrom, and J.J. Salata Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes Am. J. Physiol. 254 1988 H1157 H1166
7. A.C. Zygmunt, G.T. Eddlestone, G.P. Thomas, V.V. Nesterenko, and C. Antzelevitch Larger late sodium conductance in M cells contributes to electrical heterogeneity in canine ventricle Am. J. Physiol, Heart Circ. Physiol. 281 2001 H689 H697
8. + channels: an original mechanism of arrhythmia Circulation 107 2003: 2233 2237
9. B.F. Sakmann, A.J. Spindler, S.M. Bryant, K.W. Linz, and D. Noble Distribution of a persistent sodium current across the ventricular wall in guinea pigs Circ. Res. 87 2000: 910 914
10. H.L. Tan, C.R. Bezzina, J.P. Smits, A.O. Verkerk, and A.A. Wilde Genetic control of sodium channel function Cardiovasc. Res. 57 2003 961 973
11. C.E. Clancy, and Y. Rudy Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia Nature 400 1999 566 569
12. J.R. Balser The cardiac sodium channel: gating function and molecular pharmacology J. Mol. Cell. Cardiol. 33 2001 599 613
13. A.O. Grant Molecular biology of sodium channels and their role in cardiac arrhythmias Am. J. Med. 110 2001 296 305
14. J.C. Makielski, B. Ye, C.R. Valdivia, M.D. Pagel, J. Pu, and D.J. Tester A ubiquitous splice variant and a common polymorphism affect heterologous expression of recombinant human SCN5A heart sodium channels Circ. Res. 93 2003 821 828
15. T. Banyasz, J. Magyar, A. Kortvely, G. Szigeti, P. Szigligeti, and Z. Papp Different effects of endothelin-1 on calcium and potassium currents in canine ventricular cells Naunyn-Schmiedeberg's Arch. Pharmacol. 363 2001 383 390
16. M. Amit, M.K. Carpenter, M.S. Inokuma, C.P. Chiu, C.P. Harris, and M.A. Waknitz Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture Dev. Biol. 227 2000 271 278
17. I. Kehat, D. Kenyagin-Karsenti, M. Snir, H. Segev, M. Amit, and A. Gepstein Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes J. Clin. Invest. 108 2001 407 414
18. + channels Am. J. Physiol. 275 1998 H2016 H2024
19. C.H. Luo, and Y. Rudy A dynamic model of the cardiac ventricular action potential: I. Simulations of ionic currents and concentration changes Circ. Res. 74 1994 1071 1096
20. G.A. Gintant, N.B. Datyner, and I.S. Cohen Slow inactivation of a tetrodotoxin-sensitive current in canine cardiac Purkinje fibers Biophys. J. 45 1984 509 512
21. V.A. Maltsev, H.N. Sabbah, R.S. Higgins, N. Silverman, M. Lesch, and A.I. Undrovinas Novel, ultraslow inactivating sodium current in human ventricular cardiomyocytes Circulation 98 1998 2545 2552
22. P.B. Bennett, K. Yazawa, N. Makita, and A.L. George Molecular mechanism for an inherited cardiac arrhythmia Nature 376 1995 683 685
23. + channel mutations in the congenital long QT syndrome Proc. Natl. Acad. Sci. U. S. A. 93 1996 13200 13205
24. M.C. Haigney, E.G. Lakatta, M.D. Stern, and H.S. Silverman Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading Circulation 90 1994 391 399