Dissociation of AID expression and activity

Blood

Volumn 104, Issue 10, 2004, Pages 3001-3002

  Küppers, Ralf ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTIDINE DEAMINASE; IMMUNOGLOBULIN M; RNA;

B CELL LYMPHOMA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; GENE MUTATION; GENETIC RECOMBINATION; GERMINAL CENTER; HAIRY CELL LEUKEMIA; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; NONHODGKIN LYMPHOMA; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SOMATIC HYPERMUTATION;

EID: 8644249869     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-08-3250     Document Type: Review

References (4)

1. + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med. 1998;188:1679-1689.
2. Toellner KM, Gulbranson-Judge A, Taylor DR, Sze DM, MacLennan IC. Immunoglobulin switch transcript production in vivo related to the site and time of antigen-specific B cell activation. J Exp Med. 1996;183:2303-2312.
3. Shinkura R, Ito S, Begum NA, et al. Separate domains of AID are required for somatic hypermutation and class-switch recombination. Nat Immunol. 2004;5:707-712.
4. McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med. 2004;199:1235-1244.