Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position

Tetrahedron

Volumn 60, Issue 50, 2004, Pages 11597-11612

  De Borggraeve, Wim M ^a   Verbist, Bie M P ^a   Rombouts, Frederik J R ^a   Pawar, Vijaykumar G ^a   Smets, Wim J ^a   Kamoune, Laila ^a   Alen, Jo ^a   Van Der Eycken, Erik V ^a   Compernolle, Frans ^a   Hoornaert, Georges J ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Diels Alder reaction; Pyrazinone; Turn mimics

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; FUNCTIONAL GROUP; PEPTIDE;

ARTICLE; CHEMICAL MODEL; CHEMICAL PROCEDURES; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SYNTHESIS;

BETULACEAE;

EID: 8644235065     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.09.054     Document Type: Article

References (41)

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40. In our case, we performed the reaction in an NMR tube containing HCl saturated MeOH and the bicyclic lactam.
41. These values are derived from the analysis of small cyclic peptides. It is possible that for smaller model systems the shielding of the NH in a hydrogen bond is less efficient. So less stringent criteria might be adopted here.