Exploring QSAR with E-state index: Selectivity requirements for COX-2 versus COX-1 binding of terphenyl methyl sulfones and sulfonamides

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 18, 2004, Pages 4665-4670

  Chakraborty, Santanu ^a   Sengupta, Chandana ^a   Roy, Kunal ^a  

^a Dept Pharmaceutical Technol J   (India)

Author keywords

COX 2 inhibitors; E state index; QSAR; Terphenyl methyl sulfones and sulfonamides

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; SULFONAMIDE; SULFONE DERIVATIVE;

BINDING AFFINITY; CONFERENCE PAPER; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DIMETHYL SULFOXIDE; ELECTRICITY; LINEAR MODELS; MOLECULAR STRUCTURE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES; TERPHENYL COMPOUNDS;

EID: 8544265329     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.095     Document Type: Article

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