Indole-3-acetic acid induces microencephaly in rat fetuses

Toxicologic Pathology

Volumn 32, Issue 6, 2004, Pages 659-667

  Furukawa, Satoshi ^a   Abe, Masayoshi ^a   Usuda, Koji ^a   Ogawa, Izumi ^a  

^a NISSAN CHEMICAL INDUSTRIES LTD   (Japan)

Author keywords

Apoptosis; Fetus; Indole 3 acetic acid; Microencephaly; Neuroepithelium; Rat; Teratogen

Indexed keywords

INDOLEACETIC ACID;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN SIZE; BRAIN WEIGHT; CELL PROLIFERATION; CLEFT PALATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; FETUS; GESTATION PERIOD; HISTOPATHOLOGY; MICROCEPHALY; NEUROEPITHELIUM; NONHUMAN; PRIORITY JOURNAL; RAT; TERATOLOGY;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; APOPTOSIS; FEMALE; GESTATIONAL AGE; INDOLEACETIC ACIDS; MICROCEPHALY; NEUROEPITHELIAL CELLS; PREGNANCY; RATS; RATS, WISTAR;

ANIMALIA; RODENTIA;

EID: 8544254728     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230490520269     Document Type: Article

References (37)

1. Artigas, F., Martinez, E., Tusell, J. M., Sunol, C., and Gelpi, E. (1983). On the metabolic origin of plasmatic indole-3-acetic acid in the rat. Biochem Pharmacol 32, 3251-54.
2. Bandurski, R. S., Cohen, J. D., Slovin, J. P., and Reinecke, D. M. (1995). Hormone biosynthesis and metabolism. Auxin biosynthesis and metabolism, In Plant Hormones (P. J. Davies, ed.), pp. 39-63. Kluwer Academic Publishers, Dordrecht.
3. Bayer, S. A., and Altman, J. (2004). Development of the telencephalon: neuroral stem cells, neurogenesis, and neuronal migration. In The rat. Nervous system (G. Paxions, ed.), pp. 27-73. Elsevier Academic Press, San Diego.
4. Cattabeni, F., and Di Luca, M. (1997). Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol. Physiol Rev 77, 199-215.
5. De Melo, M. P. T., De Lima, M., Pithon-Curi, T. C., and Curi, R. (2004). The mechanism of indole acetic acid cytotoxicity. Toxicol Lett 148, 103-11.
6. Edwards, A. M., Barredo, F., Silva, E., De Ioannes, A. E., and Becker, M. I. (1999). Apoptosis induction in nonirradiated human HL-60 and murine NSO/2 tumor cells by photoproducts of indole-3-acetic acid and riboflavin. Photochem Photobiol 70, 645-9.
7. Ferguson, S. A., and Holson, R. R. (1997). Methylazoxymethanol-induced micrencephaly in the brown Norway strain: behavior and brain weight. Int J Dev Neurosci 15, 75-86.
8. Folkes, L. K., Dennis, M. F., Stratford, M. R., Candeias, L. P., and Wardman, P. (1999). Peroxidase-catalyzed effects of indole-3-acetic acid and analogues on lipid membranes, DNA, and mammalian cells in vitro. Biochem Pharmacol 57, 375-82.
9. Folkes, L. K., and Wardman, P. (2001). Oxidative activation of indole-3-acetic acids to cytotoxic species - a potential new role for plant auxins in cancer therapy. Biochem Pharmacol 61, 129-36.
10. Gordon, S. A., Fry, R. J., and Barr, S. (1972). Origin or urinary auxin in the germfree and conventional mouse. Am J Physiol 222, 399-403.
11. Greco, O., Dachs, G. U., Tozer, G. M., and Kanthou, C. (2002). Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy. J Cell Biochem 87, 221-32.
12. Gressens, P. (2000). Mechanisms and disturbances of neuronal migration. Pediatr Res 48, 725-30.
13. Hoshino, K., and Kameyama, Y. (1988). Developmental-stage-dependent radiosensitivity of neural cells in the ventricular zone of telencephalon in mouse and rat fetuses. Teratology 37, 257-62.
14. Hossain, M. M., Nakayama, H., and Goto, N. (1995). Apoptosis in the central nervous system of developing mouse fetuses from 5-azacytidine- administered dams. Toxicol Pathol 23, 367-72.
15. 2-mediated oxidation of indole-3-acetic acid at physiological pH. J Electroanal Chem 432, 7-18.
16. Ichimura, H., and Yamaki, T. (1975). Indole-3-acetic acid in animal embryos. Sci Pap Coll Gen Educ Unive Tokyo 25, 43-48.
17. John, J. A., Blogg, C. D., Murray, F. J., Schweiz, B. A., and Gehring, P. J. (1979). Teratogenic effects of the plant hormone indole-3-acetic acid in mice and rats. Teratology 19, 321-24.
18. Katayama, K., Ishigami, N., Suzuki, M., Ohtsuka, R., Kiatipattanasakul, W., Nakayama, H., and Doi, K. (2000a). Teratologic studies on rat perinates and offspring from dams treated with ethylnitrosourea (ENU). Exp Anim 49, 181-7.
19. Katayama, K., Ishigami, M., Uetsuka, K., Nakayama, H., and Doi, K. (2000b). Ethylnitrosourea (ENU)-induced apoptosis in the rat fetal tissues. Histol Histopathol 15, 707-11.
20. Kim, D. S., Jeon, S. E., and Park, K. C. (2004). Oxidation of indole-3-acetic acid by horseradish peroxidase induces apoptosis in G361 human melanoma cells. Cell Signal 16, 81-8.
21. Lu, D. P., Nakayama, H., Shinozuka, J., Uetsuka, K., Taki, R., and Doi, K. (1998). 5-azacytidine-induced apoptosis in the central nervous system of developing rat fetuses. J Toxicol Pathol 11, 133-36.
22. Martinez, E., Artigas, F., Sunol, C., Tusell, J. M., and Gelpi, E. (1983). Liquid-chromatographic determination of indole-3-acetic acid and 5-hydroxyindole-3-acetic acid in human plasma. Clin Chem 29, 1354-57.
23. Miller, M. W. (1986). Effects of alcohol on the generation and migration of cerebral cortical neurons. Science 233, 1308-11.
24. Mirsky, I. A., and Diengott, D. (1956). Hypoglycemic action of indole-3-acetic acid by mouth in patients with diabetes mellitus. Proc Soc Exp Biol Med 93, 109-10.
25. Monnet-Tschudi, F. (1998). Induction of apoptosis by mercury compounds depends on maturation and is not associated with microglial activation. J Neurosci Res 53, 361-7.
26. O'Leary, D. D. M., and Koester, S. E. (1993). Development of projection neuron types, axon pathways, and patterned connections of the mammalian cortex. Neuron 10, 991-1006.
27. Oyanagi, K., Kakita, A., Yamada, M., Kawasaki, K., Hayashi, S., and Ikuta, F. (1998). Process of repair in the neuroepithelium of developing rat brain during neurogenesis: chronological and quantitative observation of DNA-replicating cells. Dev Brain Res 15, 229-38.
28. Rice, D., and Barone, S. J. (2000). Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect 108, 511-33.
29. Ritter, E. J., Scott, W. J., and Wilson, J. G. (1971). Teratogenesis and inhibition of DNA synthesis induced in rat embryos by cytosine arabinoside. Teratology 4, 7-13.
30. Schmahl, W., Torok, P., andKriegel, H. (1984). Embryotoxicity of 5-azacytidine in mice. Phase- and dose-specificity studies. Arch Toxicol 55, 143-7.
31. Sun, X. Z., Takahashi, S., Cui, C., Zhang, R., Sakata-Haga, H., Sawada, K., and Fukui, Y. (2002). Normal and abnormal neuronal migration in the developing cerebral cortex. J Med Invest 49, 97-110.
32. Takai, H., Katayama, K., Yasohima, A., Uetsuka, K., Nakayama, H., and Doi, K. (2003). NMDA-induced apoptosis in the developing rat brain. Exp Toxic Pathol 55, 33-7.
33. Tusell, J. M., Artigas, F., Sunol, C., Martinez, E., and Gelpi, E. (1984). Comparison of high-performance liquid chromatography and gas chromatography-mass spectrometry for the analysis of indole-3-acetic acid in brain tissue. J Chromatogr 306, 338-44.
34. Ueno, M., Katayama, K., Nakayama, H., and Doi, K. (2002a). Mechanisms of 5-azacytidine (5Az-C)-induced toxicity in the rat brain. Int J Exp Path 83, 139-50.
35. Ueno, M., Katayama, K., Yasoshima, A., Nakayama, H., and Doi, K. (2002b). 5-Azacytidine (5AzC)-induced histopathological changes in the central nervous system of rat fetuses. Exp Toxicol Pathol 54, 91-96.
36. Weissbach, H., King, W., Sjoerdsma, A., and Udenfriend, S. (1959). Formation of indole-3-acetic acid and tryptamine in animals: a method for estimation of indole-3-acetic acid in tissues. J Biol Chem 234, 81-6.
37. Yamauchi, H., Katayama, K., Yasohima, A., Uetsuka, K., Nakayama, H., and Doi, K. (2003). 1-β-D-arabinofuranosylcytosine (Ara-C)-induced apoptosis in the rat fetal tissues and placenta. J Toxicol Pathol 16, 223-9.