New biomarkers of exposure;Nuovi indicatori di esposizione

Giornale Italiano di Medicina del Lavoro ed Ergonomia

Volumn 26, Issue 4, 2004, Pages 278-297

  Apostoli, P ^a   Bergonzi, R ^a   Catalani, S ^a   Neri, G ^a   Sarnico, M ^a   Foa V ^b   Fustinoni, S ^b   Colombi, A ^b   Buratti, M ^b   Campo, L ^b   Scibetta, L ^b   Sannolo, N ^c   Pieri, M ^c   Basile, A ^c   Bartolucci, G B ^d   Carrieri, M ^d   Scapellato, M L ^d   Manini, P ^e   Poli, D ^e   Corradi, M ^e   Andreoli, R ^e   Goldoni, M ^e   Mutti, A ^e   Imbriani, M ^f   Ghittori, S ^f   Maestri, L ^f   Negri, S ^f   Pira, E ^g   Pavan, I ^g   Discalzi, G ^g   Perbellini, L ^h   more..

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c SECOND UNIVERSITY OF NAPLES   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

^e UNIVERSITY OF PARMA   (Italy)

^f UNIVERSITY OF PAVIA   (Italy)

^g UNIVERSITY OF TURIN   (Italy)

^h UNIVERSITY OF VERONA   (Italy)

Author keywords

Biological monitoring; Exposure biomarkers; Occupational health; Risk assessment

Indexed keywords

BIOLOGICAL MARKER; ORGANIC COMPOUND;

ANALYTIC METHOD; BIOLOGICAL MONITORING; CONFERENCE PAPER; COST BENEFIT ANALYSIS; ENVIRONMENTAL MONITORING; HEALTH SURVEY; ITALY; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT;

ANIMALS; BIOLOGICAL MARKERS; COST-BENEFIT ANALYSIS; ENVIRONMENTAL MONITORING; FORECASTING; HUMANS; OCCUPATIONAL DISEASES; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; OCCUPATIONS; RATS; REFERENCE VALUES; RESEARCH; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

EID: 8544250599     PISSN: 15927830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (80)

1. AAVV. Conference on beryllium related diseases. Environ Health Perspect 1996; 104: 935-1001.
2. Kauppinem T, Toikkanem J, Pedersen D, et al. Occupational exposure to carcinogens in the European Union. Occup Environ Med 2000; 57: 10-18.
3. Apostoli P, Minoia C, Gilberti ME. Determination of beryllium in urine by Zeeman graphite furnace atomic adsorption spectometry in chemical laboratory and toxicology. Pergamon Press, London, 1992, pp. 495-516.
4. Angerer J, Schaller KH. Beryllium. Analysis of hazardous substances in biological materials, vol. 5°, Wiley-VCH, Weinheim, 1997.
5. Wegner R, Heinrich-Ramm R, Nowak D, et al. Lung function biological monitoring, and biological effect monitoring of gemstone cutters exposed to beryls. Occup Environ Med 2000; 57: 133-137.
6. Apostoli P, Schaller KH. A suitable tool for assessing occupational and environmental beryllium exposure? Int Arch Occup Environ Health 2001; 74: 162-167.
7. Krauss T, Scramel P, Schaller KH, Zobelein P, Weber A, Angerer J. Exposure assessment in the hard metal manufacturing industry with special regard to tungsten and its compounds. Occup Environ Med 2001; 58: 631-634.
8. Imbriani M, Zadra P, Negri S, Alessio A, Maestri L, Ghittori S. Biological monitoring of occupational exposure to sevoflurane. Med Lav 2001; 92: 173-180.
9. Haufroid V, Gardinal S, Licot C, Villapando ML, Van Obbergh L, Clippe A, Lison D. Biological monitoring of exposure to sevoflurane in operating room personnel by the measurement of hexafluoroisopropanol and fluoride in urine. Biomarkers 2000; 5: 141-151.
10. Scapellato ML, Carrieri M, Maccà I, Moretto J, Perini M, Virgili A, Gori G, Bartolucci GB. Monitoraggio ambientale e biologico dell'esposizione a sevoflurano in sala operatoria. G Ital Med Lav Erg 2003; 25: 253-257.
11. Alessio A, Zadra P, Negri S, Maestri L, Imberti R, Ghittori S, Imbriani M, Cavalleri A. Biological monitoring of occupational exposure to desflurane. G Ital Med Lav Ergon 2003; 25: 137-141.
12. Carrieri M, Scapellato ML, Maccà I, Virgili A, Perini M, Saia B, Bartolucci GB. Valutazione dell'esposizione a chemioterapici antiblastici del personale sanitario. G Ital Med Lav Erg 2003; 25: 209-214.
13. Carrieri M, Scapellato ML, Maccà I, Zoppellaro E, Salamon F, Cavedon F, Bartolucci GB. Determinazione della ciclofosfamide su superfici e nelle urine mediante gas cromatografia-spettrometria di massa. Folia Medica 2000; 71: 201-204.
14. Minoia C, Turci R, Sottani C, Perbellini L, Angeleri S, Frigerio F, Draicchio F, Apostoli P. La valutazione del rischio nel personale ospedaliero addetto alla preparazione e alla somministrazione di farmaci antitumorali. G Ital Med Lav Erg 1999; 21: 93-107.
15. Soave C, Giuliari C, Bartolucci GB, Carrieri M, Festa D, Sannolo N, Miraglia N, Acampora A, Liotti PL. Cyclophosphamide environmental contamination in drug reconstitution units in twenty one Italian hospitals. Eur. J. Hosp. Pharm. 2003; 9, 80-83.
16. Imbriani M, Niu Q, Negri S, Ghittori S. Trichloroethylene in urine as biological exposure index. Ind Health 2001; 39: 225-230.
17. Maccà I, Scapellato ML, Carrieri M, Lanzi C, Volpin A, Manno M, Treviasan A, Bartolucci GB. Indicatori di dose e di effetto in soggetti professionalmente esposti a percloroetilene. Folia Medica 2000; 71 (S2): 159-165.
18. Imbriani M, Maestri L, Marraccini P, Saretto G, Alessio A, Negri S, Ghittori S. Urinary determination of N-acetyl -S-(N-methylcarbamoyl)cysteine and N-methylformamide in workers exposed to N,N-dimethylformamide. Int Arch Occup Environ Health 2002; 75: 445-452.
19. Perbellini L, Princivalle A, Caivano M, Montagnoli R. Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite. Occup Environ Med 2003; 60: 476-751.
20. Manini P, Andreoli R, Mutti A, Bergamaschi E, Niessen WM. Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 2. Glucuronide-conjugated metabolites in untreated urine samples by electrospray ionization. Rapid Commun Mass Spectrom 1998; 12: 1615-1624.
21. Manini P, Andreoli R, Mutti A, Bergamaschi E, Franchini I. Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry. Toxicol Lett 1999; 108: 225-231.
22. Manini P, Andreoli R, Bergamaschi E, De Palma G, Mutti A, Niessen WM. A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom 2000; 14: 2055-2060.
23. Manini P, Andreoli R, Poli D, De Palma G, Mutti A, Niessen WM. Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat. Rapid Commun Mass Spectrom 2002; 16: 2239-2248.
24. De Palma G, Manini P, Mozzoni P, Andreoli R, Bergamaschi E, Cavazzini S, Franchini I, Mutti A. Polymorphism of Xenobiotic-Metabolizing Enzymes and Excretion of Styrene-Specific Mercapturic Acids. Chem Res Toxicol 2001; 14: 1393-1400.
25. Manini P, De Palma G, Mozzoni P, Andreoli R, Poli D, Bergamaschi E, Franchini I, Mutti A. GSTM1 polymorphism and styrene metabolism: insights from an acute accidental exposure. Toxicol Lett. 2002; 134: 201-208.
26. Haufroid V, Buchet J-P, Gardinal S, Ghittori S, Imbriani M, Hirvonen A, Lison D. Importance of genetic polymorphisms of drug-metabolizing enzymes for the interpretation of biomarkers of exposure to styrene. Biomarkers 2001; 6: 236-249.
27. Haufroid V, Jakubowski M, Janasik B, Ligocka D, Buchet J-P, Bergamaschi E, Manini P, Mutti A, Ghittori S, Arand M, Hangen N, Oesch F, Hirvonen A, Lison D. Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Pharmacogenetics 2002; 12: 691-702.
28. Manini P, Buzio L, Andreoli R, Goldoni M, Bergamaschi E, Jakubowski M, Vodicka P, Hirvonen A, Mutti A. Assessment of the biotransformation of the arene moiety of styrene in volunteers and occupationally exposed workers. Toxicol Appl Pharmacol 2003; 189: 160-169.
29. De Palma G, Mozzoni P, Scotti E, Manini P, Andreoli R, Naccarati A, Mercati F, Migliore L, Mutti A. Polimorfismi genetici degli enzimi della biotrasformazione ed effetti genotossici dello stirene. G Ital Med Lav Ergon 2003; 25 (3 Suppl): 63-64.
30. Manini P, De Palma G, Andreoli R, Goldoni M, Mutti A. Determination of urinary styrene metabolites in the general Italian population by liquid chromatography tandem mass spectrometry. Int Arch Occup Environ Health 2004; 77: 433-436.
31. Fustinoni S, Soleo L, Warholm M, Begemann P, Rannug A, Neumann H-G, Swenberg JA, Vimercati L, Foà V, Colombi A. Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humans. Cancer Epidemiol Biomarkers Prev 2002; 11: 1082-1090.
32. Fustinoni S, Perbellini L, Soleo L, Manno M, Foà V. Biological monitoring in occupational exposure to low level of 1,3-butadiene. Toxicol Lett 2004; 149: 353-360.
33. Begemann P, Upton PB, Ranasinghe A, Swenberg JA, Soleo L, Vimercati L, Gelormini A, Fustinoni S, Zwirner-Baier I, Neumann H-G. Hemoglobin adducts as biomarkers of 1,3-butadiene in occupationally low exposed Italian workers and few diesel-exposed miners. Chem Bio Interact 2001; 135-136: 675-678.
34. Fustinoni S, Buratti M, Giampiccolo R, Brambilla G, Foà V, Colombi A. Comparison between blood and urinary toluene as biomarkers of the exposure to toluene. Int Arch Occup Environ Health 2000; 73: 389-396.
35. Fustinoni S, Mercadante R, Campo L, Scibetta L, Valla C, Foà V. Confronto tra orto-cresolo e toluene urinari come indicatori biologici di esposizione a toluene aerodisperso. 67° Congresso SIMLII, Sorrento 2004.
36. Ghittori S, Alessio A, Negri S, Maestri L, Zadra P, Imbriani M. A field method for sampling toluene in end-exhaled air, as a biomarker of occupational exposure: correlation with other exposure indices. Ind Health 2004 Apr; 42: 226-234.
37. Pieri M, Miraglia N, Acampora A, Soleo L, Sannolo N. Determinazione di Benzene e Acido S-fenil mercapturico urinari nella valutazione dell'esposizione professionale a Benzene. G Ital Med Lav Erg 2003; 25 3 Suppl.: 348.
38. Fustinoni S, Campo L, Buratti M, Consonni D, Pesatori A, Bertazzi PA, Foà V, Merlo F. Confronto tra acido t,t-muconico, acido S-fenil-mercapturico e benzene urinari come indicatori biologici di esposizione a basse concentrazioni di benzene aerodisperso. G Ital Med Lav Erg 2003; 25: 4.
39. Fustinoni S, Giampiccolo R, Pulvirenti S, Buratti M, Colombi A. Headspace solid-phase microextraction for the determination of benzene, toluene, ethylbenzene and xylenes in urine. J Chromatogr B 1999; 723: 105-115.
40. Andreoli R, Manini P, Bergamaschi E, Brustolin A, Mutti A. Solid-phase microextraction and gas chromatography-mass spectrometry for determination of monoaromatic hydrocarbons in blood and urine: application to people exposed to air pollutants. Chromatographia 1999; 50: 167-172.
41. Perbellini L, Pasini F, Romani S, Princivalle A, Brugnone F. Analysis of benzene, toluene, ethylbenzene and m-xylene in biological samples from the general population. J Chromatogr B 2002; 778: 199-210.
42. Perbellini L, Buratti M, Fiorentino ML, Fustinoni S, Pasini F, Magnaghi S. Matrix interferences in the analysis of benzene in urine. J Chromatogr B 1999; 724: 257-264.
43. Buratti M, Brambilla G, Fustinoni S, Pellegrino O, Pulvirenti S, Colombi A. Determination of monofluorobimaile derivatives of phenyl-mercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetry. J Chromatogr B 2001; 751: 305-313.
44. Andreoli R, Manini P, Bergamaschi E, Mutti A. Determinazione dell'acido S-fenilmercapturico mediante cromatografia liquidaspettrometria di massa tandem con ionizzazione electrospray. XX Congresso Nazionale della Società Chimica Italiana, Rimini, 4-9 giugno 2000.
45. Pieri M, Miraglia N, Acampora A, Genovese G, Soleo L, Sannolo N. Determination of urinary S-phenylmercapturic acid by liquid chromatography- tandem mass spectrometry. J. Chromatogr. B 2003; 795: 347-354.
46. Giarin E, Gori G, Perico A, Bavazzano P, Pasin P, Bartolucci GB. Metodo per la determinazione di basse concentrazioni dell'acido trans,trans-muconico urinario. Atti del 16° Congresso Nazionale della Associazione Italiana degli Igienisti Industriali Faenza, 19-21 giugno 1997. Le Collane della Fondazione Salvatore Maugeri, 1 documenti, 14, pp. 206-208.
47. Bartolucci GB, Giarin E, Carrieri M, Guarnieri G, Maccà I, Volpin A. Esposizione a benzene di conducenti di autobus urbani. Lavoro e Medicina 1999; 2: 65-68.
48. Bartolucci GB, Giarin E, Carrieri M, Scapellato ML, Marcuzzo G, Gori G, Chatzis C, Cocheo V, Saia B. Exposure to benzene and urinary excretion of trans,trans-muconic acid in general population of Padua and Athens. Proceedings of International Conference Air Quality in Europe Challenges for the 2000s. Venice, 19-21 May 1999.
49. Negri S, Maestri L, Alessio A, Ghittori S, Imbriani M. Determinazione dell'acido sorbico urinario mediante LC-MS. G Ital Med Lav Erg 2003; 25 (3 Suppl): 387-388.
50. Fustinoni S, Campo L, Colosio C, Birindelli S, Foà V. A gas chromatography/mass spectrometry method for the determination of urinary ethylenthiourea in humans. J Chromatogr B (accettato).
51. Colosio C, Fustinoni S, Birindelli S, Bonomi I, De Paschale G, Mammone T, Tiramani M, Vercelli F, Visentin S, Maroni M. Ethylenethiourea in urine as an indicator of exposure to mancozeb in vineyard workers. Toxicol Lett 2002; 134: 133-140.
52. Lichtenstein N, Pfaumbaum W, Quellmalz K, Bernards M, Henning M. Qualitative analysis of carcinogenic aromatic amines from azo dyes after azo cleavage. Reinhaltung der Luft 1997; 57: 139-145.
53. Pavan I, Buglione E, Passini V, Botta GC, Cugliari G, Merlo E, Pira E, Graziano M. L'utilizzo del monitoraggio biologico in addetti alla preparazione di vernici in polvere come strumento per l'identificazione del rischio da ammine aromatiche (3,3′-diclorobenzidina). Atti XVIII Congresso Nazionale AIDII, 2000, 87-93.
54. Pavan I, Baroffio C, Buglione E, Passini V, Pira E. Ammine aromatiche ad azione cancerogena certa, probabile o possibile: valori di riferimento. G Ital Med Lav Erg 2003; 25: 68-73.
55. Schramel P, Wendler I, Angerer J. The determination of metals (antimony, bismuth, lead, cadium, mercury, palladium, platinum, tellurium, tin and tungsten) in urine samples by inductively coupled plasma-mass spectometry. Int Arch Occup Environ Health 1997; 69: 219-223.
56. Apostoli P. Rischi correlati all'esposizione lavorativa a metalli. Linee Guida SIMLII per i medici del lavoro", Pavia 19-20 maggio 2003.
57. Apostoli P, Cortesi I. Quadro sulle criticità ambientali delle acciaierie elettriche, Atti del Convegno Nazionale su "Quadro di riferimento sull'impatto ambientale dell'industria metallurgica", Brescia, 12 giugno 2003.
58. Apostoli P, Giusti S, Bartoli D, Perico A, Bavazzano P, Alessio L. Multiple exposure to arsenic, antimony and other elements in art glass manufacturing Am J Ind Med 1998; 34: 65-72.
59. Scibetta L, Campo L, Mercadante R, Buratti M, Rubino FM, Colonibi A, Foà V, Fustinoni S. Valutazione di MtBE urinario indicatore biologico di esposizione a vapori di benzina e traffico autoveicolare. 67° Congresso SIMLII, Sorrento 2004 (Sottoposto).
60. Saarinen L, Hakkola M, Pekari K, Lappalainen K, Aitio A. Exposure of gasoline road-tanker drivers to methyl tert-butyl ether and methyl tert-amyl ether. Int Arch Occup Environ Health 1998; 71: 143-147.
61. Perbellini L, Pasini F, Prigioni P, Rosina A. Esposizione professionale a metil tert-butiletere (MTBE) in una raffineria di petrolio. G Ital Med Lav Ergon 2003; 25 (3 Suppl): 39-40.
62. Buratti M, Pellegrino O, Brambilla G, Colombi A. Urinary excretion of 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons from different sources. Biomarkers 2000; 5: 368-381.
63. Waidyanatha S, Zheng Y, Rappaport SM. Determination of polycyclic aromatic hydrocarbons in urine of coke coven workers by head-space solid phase microextraction and gas chomatography-mass spectrometry. Chem Bio Interact 2003; 145: 165-174.
64. Campo L, Addario L, Scibetta L, Buratti M, Foà V, Longhi O, Cirla P, Martinetti I, Fustinoni S. Nuovi indicatori per il monitoraggio biologico dell'esposizione a idrocarburi policiclici aromatici: gli IPA urinari. 67° Congresso SIMLII, Sorrento 2004 (Sottoposto).
65. Apostoli P, Brugnone F, Perbellini L, Fraccaroli V, Cocheo V. Esposizione professionale a policlorobifenili: identificazione e dosaggio dei singoli composti nell'aria ambientale e nel sangue. Ann Ist Sup Sanità 1982; 18: 1065-1068.
66. Gladen BC, Doucet J, Hansen LG. Assessing human polychlorinated biphenyl contamination for epidemiologic studies: lessons from patterns of congener concentration in Canadians in 1992. Environ Health Perspect 2003, 111: 437-443.
67. Apostoli P. Elements in environmental and occupational medicine. J Chromatogr B 2002; 778: 63-97.
68. Apostoli P, Bartoli D, Alessio L, Buchet J-P. Biological monitoring of occupational exposure to inorganic arsenic. Occup Environ Med 1998; 12: 825-832.
69. Apostoli P, Fenga C, Sarnico M, Germanò D. Cute, suoi annessi e secreti come matrici per il monitoraggio biologico di elementi tossici. G Ital Med Lav Erg 2002; 24: 188-191.
70. Bergdahl IA, Schutz A, Gerhardsson L, Jensen A, Skefering S. Lead concentration in human plasma, urine, and whole blood. Scand J Work Environ Health 1997; 23: 289-293.
71. Smith D, Hernandez-Avila M, Tellez-Rojo MM, Mercado A, Hu H. The relationship between lead in plasma and whole blood in women. Environ Health Perspect 2002; 110: 263-265.
72. Hirata M, Yoshida T, Miyajima K, Kosoka H, Tabuchi T. Correlation between lead in plasma and other of lead exposure lead-exposed workers. Int Arch Occup Environ Health, 1995; 68: 58-63.
73. Neri G, Apostoli P. "Risultati della ricerca cofinanziata MIUR - Esposizione ambientale ed occupazionale a piombo inorganico: studio degli effetti tossici conseguenti alle dosi correnti e delle relative misure preventive. Indicatori di effetto sull'eme" Atti del congresso nazionale, pp. 6-7, Brescia, 2004.
74. th International Conference, Seattle May 2003.
75. Goldoni M, Catalani S, De Palma G, Manini P, Acampa O, Corradi M, Bergonzi R, Apostoli P, Mutti A. Exhaled breath condensate as a suitable matrix to assess lung dose and effects in workers exposed to cobalt and tungsten. Environ Health Perspect, 2004; 112: 1293-1298 [Epub ahead of print Jun 10, 2004].
76. Gil F, Pla A. Biomarkers as biological indicators of xenobiotics exposure. J Appl Toxicol 2001; 21: 245-255.
77. Silbergeld EK, Davis DL. Role of biomarkers in identifying and understanding environmentally induced disease. Clin Chem 1994; 40: 1363-1367.
78. Aitio A. Biomarkers and their use in occupational medicine. Scand J Work Environ Health 1999; 25: 521-528.
79. ACGIH. Threshold Limits Values and Biological exposure Indices, 2003, Cincinnati OH USA.
80. DFG List of MAK and BAT values, 2003, Wiley VCH GmbH & KgaA, Wienheim D.