Agents of systemic and subcutaneous mucormycosis and entomophthoromycosis

Manual of Clinical Microbiology: Tenth Edition

Volumn 2-2, Issue , 2022, Pages 1880-1901

  Garcia Hermoso, Dea ^a   Dannaoui, Eric ^a   Lortholary, Olivier ^a   Dromer, Françoise ^a  

^a CNRS   (France)

Author keywords

B. ranarum; C. coronatus; Entomophthoromycosis; Histopathology; Mucormycosis

Indexed keywords

EID: 85188875831     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1128/9781555816728.ch119     Document Type: Chapter

References (131)

1. Abe, A., T. Sone, I. N. Sujaya, K. Saito, Y. Oda, K. Asano, and F. Tomita. 2003. rDNA ITS sequence of Rhizopus oryzae: its application to classification and identification of lactic acid producers. Biosci. Biotechnol. Biochem. 67:1725-1731.
2. Almaslamani, M., S. J. Taj-Aldeen, D. Garcia-Hermoso, E. Dannaoui, H. Alsoub, and A. Alkhal. 2009. An increasing trend of cutaneous zygomycosis caused by Mycocladus corymbifer (formerly Absidia corymbifera): report of two cases and review of primary cutaneous Mycocladus infections. Med. Mycol. 47:532-538.
3. Almyroudis, N. G., D. A. Sutton, A. W. Fothergill, M. G. Rinaldi, and S. Kusne. 2007. In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Antimicrob. Agents Chemother. 51:2587-2590.
4. Alvarez, E., D. A. Sutton, J. Cano, A. W. Fothergill, A. Stchigel, M. G. Rinaldi, and J. Guarro. 2009. Spectrum of zygomycete species identified in clinically significant specimens in the United States. J. Clin. Microbiol. 47:1650-1656.
5. Balajee, S. A., A. M. Borman, M. E. Brandt, J. Cano, M. Cuenca-Estrella, E. Dannaoui, J. Guarro, G. Haase, C. C. Kibbler, W. Meyer, K. O'Donnell, C. A. Petti, J. L. Rodriguez-Tudela, D. Sutton, A. Velegraki, and B. L. Wickes. 2009. Sequence-based identification of Aspergillus, Fusarium, and Mucorales species in the clinical mycology laboratory: where are we and where should we go from here? J. Clin. Microbiol. 47:877-884.
6. Barchiesi, F., E. Spreghini, A. Santinelli, A. W. Fothergill, E. Pisa, D. Giannini, M. G. Rinaldi, and G. Scalise. 2007. Posaconazole prophylaxis in experimental systemic zygomyco- sis. Antimicrob. Agents Chemother. 51:73-77.
7. Ben-Ze'ev, I., and R. Kenneth. 1982. Criteria of taxonomic value in the Entomophthorales. Mycotaxon 14:393-455.
8. Bialek, R., F. Konrad, J. Kern, C. Aepinus, L. Cecenas, G. M. Gonzalez, G. Just-Nubling, B. Willinger, E. Presterl, C. Lass-Florl, and V. Rickerts. 2005. PCR based identification and discrimination of agents of mucormycosis and aspergillosis in paraffin wax embedded tissue. J. Clin. Pathol. 58:1180-1184.
9. Bigliazzi, C., V. Poletti, D. Dell'Amore, L. Saragoni, and T. V. Colby. 2004. Disseminated basidiobolomycosis in an immunocompetent woman. J. Clin. Microbiol. 42:1367-1369.
10. Bitar, D., D. Van Cauteren, F. Lanternier, E. Dannaoui, D. Che, F. Dromer, J. Descenclos, and O. Lortholary. 2009. Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006. Emerg. Infect. Dis. 15:1395-1401.
11. Bittencourt, A. L., R. Marback, and L. M. Nossa. 2006. Mucocutaneous entomophthoramycosis acquired by conjunctival inoculation of the fungus. Am. J. Trop. Med. Hyg. 75:936-938.
12. Bjorkholm, M., G. Runarsson, F. Celsing, M. Kalin, B. Petrini, and P. Engervall. 2001. Liposomal amphotericin B and surgery in the successful treatment of invasive pulmonary mucormycosis in a patient with acute T-lymphoblastic leukemia. Scand. J. Infect. Dis. 33:316-319.
13. Blanchet, D., E. Dannaoui, A. Fior, F. Huber, P. Couppie, N. Salhab, D. Hoinard, and C. Aznar. 2008. Saksenaea vasiformis infection, French Guiana. Emerg. Infect. Dis. 14:342-344.
14. Blin, N., N. Morineau, F. Gaillard, O. Morin, N. Milpied, J. L. Harousseau, and P. Moreau. 2004. Disseminated mucormycosis associated with invasive pulmonary aspergillosis in a patient treated for post-transplant high-grade nonHodgkin's lymphoma. Leuk. Lymphoma 45:2161-2163.
15. Cameron, H. M. 1989. Entomophthoromycosis, p. 186-198. In E. S. Mahgoub (ed.), Tropical Mycosis. Janssen Research Council, Beerse, Belgium.
16. Chakrabarti, A., A. Das, J. Mandal, M. R. Shivaprakash, V. K. George, B. Tarai, P. Rao, N. Panda, S. C. Verma, and V. Sakhuja. 2006. The rising trend of invasive zygomycosis in patients with uncontrolled diabetes mellitus. Med. Mycol. 44:335-342.
17. Chakrabarti, A., A. Ghosh, G. S. Prasad, J. K. David, S. Gupta, A. Das, V. Sakhuja, N. K. Panda, S. K. Singh, S. Das, and T. Chakrabarti. 2003. Apophysomyces elegans: an emerging zygomycete in India. J. Clin. Microbiol. 41:783-788.
18. Chamilos, G., R. E. Lewis, and D. P. Kontoyiannis. 2008. Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis. Clin. Infect. Dis. 47:503-509.
19. Chamilos, G., E. M. Marom, R. E. Lewis, M. S. Lionakis, and D. P. Kontoyiannis. 2005. Predictors of pulmonary zy- gomycosis versus invasive pulmonary aspergillosis in patients with cancer. Clin. Infect. Dis. 41:60-66.
20. Chayakulkeeree, M., M. A. Ghannoum, and J. R. Perfect. 2006. Zygomycosis: the re-emerging fungal infection. Eur. J. Clin. Microbiol. Infect. Dis. 25:215-229.
21. Clinical and Laboratory Standards Institute (CLSI). 2007. Interpretive Criteria for Identification of Bacteria and Fungi by DNA Target Sequencing; Approved Guideline MM-18A. CLSI, Wayne, PA.
22. Clinical and Laboratory Standards Institute (CLSI). 2002. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi: Approved Standard. Document M-38A. CLSI, Wayne, PA.
23. Cornely, O. A., J. Maertens, D. J. Winston, J. Perfect, A. J. Ullmann, T. J. Walsh, D. Helfgott, J. Holowiecki, D. Stockelberg, Y. T. Goh, M. Petrini, C. Hardalo, R. Suresh, and D. Angulo-Gonzalez. 2007. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N. Engl. J. Med. 356:348-359.
24. Dannaoui, E. 2006. Animal models for evaluation of antifungal efficacy against filamentous fungi, p. 115-136. In K. Kavanagh (ed.), Medical Mycology: Cellular and Molecular Techniques. John Wiley & Sons, Bognor Regis, United Kingdom.
25. Dannaoui, E. 2009. Molecular tools for identification of Zygomycetes and diagnosis of zygomycosis. Clin. Microbiol. Infect. 15(Suppl. 5):66-70.
26. Dannaoui, E., J. F. Meis, D. Loebenberg, and P. E. Verweij. 2003. Activity of posaconazole in treatment of experimental disseminated zygomycosis. Antimicrob. Agents Chemother. 47:3647-3650.
27. Dannaoui, E., J. F. Meis, J. W. Mouton, and P. E. Verweij. 2002. In vitro susceptibilities of Zygomycota to polyenes. J. Antimicrob. Chemother. 49:741-744.
28. Dannaoui, E., J. Meletiadis, J. W. Mouton, J. F. Meis, and P. E. Verweij. 2003. In vitro susceptibilities of zygomycetes to conventional and new antifungals. J. Antimicrob. Chemother. 51:45-52.
29. Dannaoui, E., J. W. Mouton, J. F. Meis, and P. E. Verweij. 2002. Efficacy of antifungal therapy in a nonneutropenic murine model of zygomycosis. Antimicrob. Agents Chemother. 46:1953-1959.
30. Reference deleted.
31. de Hoog, G. S., J. Guarro, J. Gené, and M. J. Figueras. 2009. Atlas of Clinical Fungi CD-ROM. A Pilot CD-ROM Version of the 3rd Edition. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.
32. Denning, D. W., C. C. Kibbler, and R. A. Barnes. 2003. British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections. Lancet Infect. Dis. 3:230-240.
33. De Pauw, B., T. J. Walsh, J. P. Donnelly, D. A. Stevens, J. E. Edwards, T. Calandra, P. G. Pappas, J. Maertens, O. Lortholary, C. A. Kauffman, D. W. Denning, T. F. Patterson, G. Maschmeyer, J. Bille, W. E. Dismukes, R. Herbrecht, W. W. Hope, C. C. Kibbler, B. J. Kullberg, K. A. Marr, P. Munoz, F. C. Odds, J. R. Perfect, A. Restrepo, M. Ruhnke, B. H. Segal, J. D. Sobel, T. C. Sorrell, C. Viscoli, J. R. Wingard, T. Zaoutis, and J. E. Bennett. 2008. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/ MSG) Consensus Group. Clin. Infect. Dis. 46:1813-1821.
34. Dromer, F., and M. R. McGinnis. 2002. Zygomycosis, p. 297-308. In E. Anaissie, M. R. McGinnis, and M. A. Pfaller (ed.), Clinical Mycology. Churchill Livingstone, New York, NY.
35. Ellis, D., S. Davis, H. Alexiou, R. Handke, and R. Bartley. 2007. Descriptions of Medical Fungi, 2nd ed. Mycology Unit, Women's and Children's Hospital, Adelaide, Australia.
36. Espinel-Ingroff, A. 2006. Comparison of three commercial assays and a modified disk diffusion assay with two broth microdilution reference assays for testing zygomycetes, Aspergillus spp., Candida spp., and Cryptococcus neoformans with posacon- azole and amphotericin B. J. Clin. Microbiol. 44:3616-3622.
37. Frater, J. L., G. S. Hall, and G. W. Procop. 2001. Histologic features of zygomycosis: emphasis on perineural invasion and fungal morphology. Arch. Pathol. Lab. Med. 125:375-378.
38. Fromentin, H., and P. Ravisse. 1977. Tropical ento- mophthoromycoses. Acta Trop. 34:375-394.
39. Gams, W., E. Hoekstra, and A. Aptroot. 1998. CBS Course of Mycology. Centraalbureau voor Schimmelcultures, Baarn, The Netherlands.
40. Garcia-Hermoso, D., and E. Dannaoui. 2007. The Zygomycetes, p. 159-183. In K. Kavanagh (ed.), New Insights in Medical Mycology. Springer Science, New York, NY.
41. Garcia-Hermoso, D., D. Hoinard, J. C. Gantier, F. Grenouillet, F. Dromer, and E. Dannaoui. 2009. Molecular and phenotypic evaluation of Lichtheimia corymbifera (formerly Absidia corymbifera) complex isolates associated with human mucormycosis: rehabilitation of L. ramosa. J. Clin. Microbiol. 47:3862-3870.
42. Girmenia, C., M. L. Moleti, A. Micozzi, A. P. Iori, W. Barberi, R. Foa, and P. Martino. 2005. Breakthrough Candida krusei fungemia during fluconazole prophylaxis followed by breakthrough zygomycosis during caspofungin therapy in a patient with severe aplastic anemia who underwent stem cell transplantation. J. Clin. Microbiol. 43:5395-5396.
43. Glazer, M., S. Nusair, R. Breuer, J. Lafair, Y. Sherman, and N. Berkman. 2000. The role of BAL in the diagnosis of pulmonary mucormycosis. Chest 117:279-282.
44. Greenberg, R. N., L. J. Scott, H. H. Vaughn, and J. A. Ribes. 2004. Zygomycosis (mucormycosis): emerging clinical importance and new treatments. Curr. Opin. Infect. Dis. 17:517-525.
45. Guarro, J., C. Aguilar, and I. Pujol. 1999. In-vitro antifungal susceptibilities of Basidiobolus and Conidiobolus spp. strains. J. Antimicrob. Chemother. 44:557-560.
46. Gugnani, H. C. 1992. Entomophthoromycosis due to Conid- iobolus. Eur. J. Epidemiol. 8:391-396.
47. Gugnani, H. C. 1999. A review of zygomycosis due to Basidi- obolus ranarum. Eur. J. Epidemiol. 15:923-929.
48. Hall, L., S. Wohlfiel, and G. D. Roberts. 2004. Experience with the MicroSeq D2 large-subunit ribosomal DNA sequencing kit for identification of filamentous fungi encountered in the clinical laboratory. J. Clin. Microbiol. 42:622-626.
49. Hata, D. J., S. P. Buckwalter, B. S. Pritt, G. D. Roberts, and N. L. Wengenack. 2008. Real-time PCR method for detection of zygomycetes. J. Clin. Microbiol. 46:2353-2358.
50. Hayden, R. T., X. Qian, G. W. Procop, G. D. Roberts, and R. V. Lloyd. 2002. In situ hybridization for the identification of filamentous fungi in tissue section. Diagn. Mol. Pathol. 11:119-126.
51. Hibbett, D. S., M. Binder, J. F. Bischoff, M. Blackwell, P. F. Cannon, O. E. Eriksson, S. Huhndorf, T. James, P. M. Kirk, R. Lucking, H. Thorsten Lumbsch, F. Lutzoni, P. B. Matheny, D. J. McLaughlin, M. J. Powell, S. Redhead, C. L. Schoch, J. W. Spatafora, J. A. Stalpers, R. Vilgalys, M. C. Aime, A. Aptroot, R. Bauer, D. Begerow, G. L. Benny, L. A. Castlebury, P. W. Crous, Y. C. Dai, W. Gams, D. M. Geiser, G. W. Griffith, C. Gueidan, D. L. Hawksworth, G. Hestmark, K. Hosaka, R. A. Humber, K. D. Hyde, J. E. Ironside, U. Koljalg, C. P. Kurtzman, K. H. Larsson, R. Lichtwardt, J. Longcore, J. Miadlikowska, A. Miller, J. M. Moncalvo, S. Mozley-Standridge, F. Oberwinkler, E. Parmasto, V. Reeb, J. D. Rogers, C. Roux, L. Ryvarden, J. P. Sampaio, A. Schussler, J. Sugiyama, R. G. Thorn, L. Tibell, W. A. Untereiner, C. Walker, Z. Wang, A. Weir, M. Weiss, M. M. White, K. Winka, Y. J. Yao, and N. Zhang. 2007. A higher-level phylogenetic classification of the Fungi. Mycol. Res. 111:509-547.
52. Hoffmann, K., S. Discher, and K. Voigt. 2007. Revision of the genus Absidia (Mucorales, Zygomycetes) based on physiological, phylogenetic, and morphological characters; thermotolerant Absidia spp. form a coherent group, Mycocladiaceae fam. nov. Mycol. Res. 111:1169-1183.
53. Hoffmann, K., G. Walther, and K. Voight. 2009. Mycocladus vs. Lichtheimia: a correction (Lichtheimiaceae fam. nov., Mucor- ales, Mucoromycotina). Mycol. Res. 113:277-278.
54. Holland, J. 1997. Emerging zygomycoses of humans: Saksenaea vasiformis and Apophysomyces elegans. Curr. Top. Med. Mycol. 8:27-34.
55. Hussein, M. R. 2008. Mucocutaneous Splendore-Hoeppli phenomenon. J. Cutan. Pathol. 35:979-988.
56. Ibrahim, A. S., V. Avanessian, B. Spellberg, and J. E. Edwards, Jr. 2003. Liposomal amphotericin B, and not amphotericin B deoxycholate, improves survival of diabetic mice infected with Rhizopus oryzae. Antimicrob. Agents Chemother. 47:3343-3344.
57. Ibrahim, A. S., J. C. Bowman, V. Avanessian, K. Brown, B. Spellberg, J. E. Edwards, Jr., and C. M. Douglas. 2005. Caspo- fungin inhibits Rhizopus oryzae 1,3-beta-d-glucan synthase, lowers burden in brain measured by quantitative PCR, and improves survival at a low but not a high dose during murine disseminated zygomycosis. Antimicrob. Agents Chemother. 49:721-727.
58. Imhof, A., S. A. Balajee, D. N. Fredricks, J. A. Englund, and K. A. Marr. 2004. Breakthrough fungal infections in stem cell transplant recipients receiving voriconazole. Clin. Infect. Dis. 39:743-746.
59. Iwen, P. C., A. G. Freifeld, L. Sigler, and S. R. Tarantolo. 2005. Molecular identification of Rhizomucor pusillus as a cause of sinus-orbital zygomycosis in a patient with acute myelogenous leukemia. J. Clin. Microbiol. 43:5819-5821.
60. Jensen, H. E., J. Salonen, and T. O. Ekfors. 1997. The use of immunohistochemistry to improve sensitivity and specificity in the diagnosis of systemic mycoses in patients with haematological malignancies. J. Pathol. 181:100-105.
61. Kasai, M., S. M. Harrington, A. Francesconi, V. Petraitis, R. Petraitiene, M. G. Beveridge, T. Knudsen, J. Milanovich, M. P. Cotton, J. Hughes, R. L. Schaufele, T. Sein, J. Bacher, P. R. Murray, D. P. Kontoyiannis, and T. J. Walsh. 2008. Detection of a molecular biomarker for zygomycetes by quantitative PCR assays of plasma, bronchoalveolar lavage, and lung tissue in a rabbit model of experimental pulmonary zygomycosis. J. Clin. Microbiol. 46:3690-3702.
62. Khan, Z. U., S. Ahmad, A. Brazda, and R. Chandy. 2009. Mucor circinelloides as a cause of invasive maxillofacial zygo- mycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole. J. Clin. Microbiol. 47:1244-1248.
63. Kobayashi, M., K. Togitani, H. Machida, Y. Uemura, Y. Ohtsuki, and H. Taguchi. 2004. Molecular polymerase chain reaction diagnosis of pulmonary mucormycosis caused by Cun- ninghamella bertholletiae. Respirology 9:397-401.
64. Kontoyiannis, D. P., G. Chamilos, S. A. Hassan, R. E. Lewis, N. D. Albert, and J. J. Tarrand. 2007. Increased culture recovery of Zygomycetes under physiologic temperature conditions. Am. J. Clin. Pathol. 127:208-212.
65. Kontoyiannis, D. P., M. S. Lionakis, R. E. Lewis, G. Chamilos, M. Healy, C. Perego, A. Safdar, H. Kantarjian, R. Champlin, T. J. Walsh, and I. I. Raad. 2005. Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy: a case-control observational study of 27 recent cases. J. Infect. Dis. 191:1350-1360.
66. Reference deleted.
67. Kontoyiannis, D. P., V. C. Wessel, G. P. Bodey, and K. V. Rolston. 2000. Zygomycosis in the 1990s in a tertiary-care cancer center. Clin. Infect. Dis. 30:851-856.
68. Kwon-Chung, K., and J. Bennett. 1982. Medical Mycology. Lea & Febiger, Philadelphia, PA.
69. Lanternier, F., and O. Lortholary. 2008. Liposomal amphotericin B: what is its role in 2008? Clin. Microbiol. Infect. 14(Suppl. 4):71-83.
70. Lanternier, F., and O. Lortholary. 2009. Zygomycosis in diabetes. Clin. Microbiol. Infect. 15(Suppl. 5):21-25.
71. Larche, J., M. Machouart, K. Burton, J. Collomb, M. F. Biava, A. Gerard, and B. Fortier. 2005. Diagnosis of cutaneous mucormycosis due to Rhizopus microsporus by an innovative PCR-restriction fragment-length polymorphism method. Clin. Infect. Dis. 41:1362-1365.
72. Lau, A., S. Chen, T. Sorrell, D. Carter, R. Malik, P. Martin, and C. Halliday. 2007. Development and clinical application of a panfungal PCR assay to detect and identify fungal DNA in tissue specimens. J. Clin. Microbiol. 45:380-385.
73. Lechevalier, P., D. Garcia Hermoso, A. Carol, S. Bonacorsi, L. Ferkdadji, F. Fitoussi, O. Lortholary, A. Bourrillon, A. Faye, E. Dannaoui, and F. Angoulvant. 2008. Molecular diagnosis of Saksenaea vasiformis cutaneous infection after scorpion sting in an immunocompetent adolescent. J. Clin. Microbiol. 46:3169-3172.
74. Lee, F. Y., S. B. Mossad, and K. A. Adal. 1999. Pulmonary mucormycosis: the last 30 years. Arch. Intern. Med. 159:1301-1309.
75. Lemmer, K., H. Losert, V. Rickerts, G. Just-Nubling, A. Sander, M. L. Kerkmann, and K. Tintelnot. 2002. Molecular biological identification of Cunninghamella species. Mycoses 45(Suppl. 1):31-36.
76. Lyon, G. M., J. D. Smilack, K. K. Komatsu, T. M. Pasha, J. A. Leighton, J. Guarner, T. V. Colby, M. D. Lindsley, M. Phelan, D. W. Warnock, and R. A. Hajjeh. 2001. Gastrointestinal basidiobolomycosis in Arizona: clinical and epidemiological characteristics and review of the literature. Clin. Infect. Dis. 32:1448-1455.
77. Ma, L. J., A. S. Ibrahim, C. Skory, M. G. Grabherr, G. Burger, M. Butler, M. Elias, A. Idnurm, B. F. Lang, T. Sone, A. Abe, S. E. Calvo, L. M. Corrochano, R. Engels, J. Fu, W. Hansberg, J. M. Kim, C. D. Kodira, M. J. Koehrsen, B. Liu, D. Miranda-Saavedra, S. O'Leary, L. Ortiz-Castellanos, R. Poulter, J. Rodriguez-Romero, J. Ruiz-Herrera, Y. Q. Shen, Q. Zeng, J. Galagan, B. W. Birren, C. A. Cuomo, and B. L. Wickes. 2009. Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication. PLoS Genet. 5:e1000549.
78. Machouart, M., J. Larche, K. Burton, J. Collomb, P. Maurer, A. Cintrat, M. F. Biava, S. Greciano, A. F. Kuijpers, N. Contet-Audonneau, G. S. de Hoog, A. Gerard, and B. Fortier. 2006. Genetic identification of the main opportunistic Mucorales by PCR-restriction fragment length polymorphism. J. Clin. Microbiol. 44:805-810.
79. Marr, K. A., R. A. Carter, F. Crippa, A. Wald, and L. Corey. 2002. Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients. Clin. Infect. Dis. 34:909-917.
80. Marty, F. M., L. A. Cosimi, and L. R. Baden. 2004. Breakthrough zygomycosis after voriconazole treatment in recipients of hematopoietic stem-cell transplants. N. Engl. J. Med. 350:950-952.
81. Nagao, K., T. Ota, A. Tanikawa, Y. Takae, T. Mori, S. Udagawa, and T. Nishikawa. 2005. Genetic identification and detection of human pathogenic Rhizopus species, a major mucormycosis agent, by multiplex PCR based on internal transcribed spacer region of rRNA gene. J. Dermatol. Sci. 39:23-31.
82. Neofytos, D., D. Horn, E. Anaissie, W. Steinbach, A. Olyaei, J. Fishman, M. Pfaller, C. Chang, K. Webster, and K. Marr. 2009. Epidemiology and outcome of invasive fungal infection in adult hematopoietic stem cell transplant recipients: analysis of Multicenter Prospective Antifungal Therapy (PATH) Alliance registry. Clin. Infect. Dis. 48:265-273.
83. Nosari, A., M. Anghilieri, G. Carrafiello, C. Guffanti, L. Marbello, M. Montillo, G. Muti, S. Ribera, A. Vanzulli, M. Nichelatti, and E. Morra. 2003. Utility of percutaneous lung biopsy for diagnosing filamentous fungal infections in hematologic malignancies. Haematologica 88:1405-1409.
84. Nosari, A., P. Oreste, M. Montillo, G. Carrafiello, M. Draisci, G. Muti, A. Molteni, and E. Morra. 2000. Mucormycosis in hematologic malignancies: an emerging fungal infection. Haematologica 85:1068-1071.
85. Nyilasi, I., T. Papp, A. Csernetics, K. Krizsan, E. Nagy, and C. Vagvolgyi. 2008. High-affinity iron permease (FTR1) gene sequence-based molecular identification of clinically important Zygomycetes. Clin. Microbiol.. Infect. 14:393-397.
86. O'Donnell, K., F. Lutzoni, T. J. Ward, and G. L. Benny. 2001. Evolutionary relationships among mucoralean fungi (Zygomycota): evidence for family polyphyly on a large scale. Mycologia 93:286-296.
87. Okafor, J. I., D. Testrake, H. R. Mushinsky, and B. G. Yangco. 1984. A Basidiobolus sp. and its association with reptiles and amphibians in southern Florida. Sabouraudia 22:47-51.
88. Padhye, A. A., and L. Ajello. 1988. Simple method of inducing sporulation by Apophysomyces elegans and Saksenaea vasiformis. J. Clin. Microbiol. 26:1861-1863.
89. Pagano, L., M. Caira, A. Candoni, M. Offidani, L. Fianchi, B. Martino, D. Pastore, M. Picardi, A. Bonini, A. Chierichini, R. Fanci, C. Caramatti, R. Invernizzi, D. Mattei, M. E. Mitra, L. Melillo, F. Aversa, M. T. Van Lint, P. Falcucci, C. G. Valentini, C. Girmenia, and A. Nosari. 2006. The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study. Haema- tologica 91:1068-1075.
90. Pagano, L., M. Offidani, L. Fianchi, A. Nosari, A. Candoni, M. Piccardi, L. Corvatta, D. D'Antonio, C. Girmenia, P. Martino, and A. Del Favero. 2004. Mucormycosis in hematologic patients. Haematologica 89:207-214.
91. Reference deleted.
92. Parkyn, T., A. W. McNinch, T. Riordan, and M. Mott. 2000. Zygomycosis in relapsed acute leukaemia. J. Infect. 41:265-268.
93. Prabhu, R. M., and R. Patel. 2004. Mucormycosis and en- tomophthoramycosis: a review of the clinical manifestations, diagnosis and treatment. Clin. Microbiol. Infect. 10(Suppl. 1):31-47.
94. Reference deleted.
95. Receveur, M. C., C. Roussin, B. Mienniel, O. Gasnier, J. P. Riviere, D. Malvy, and O. Lortholary. 2005. Rhinofacial entomophthoromycosis. About two new cases in Mayotte. Bull. Soc. Pathol. Exot. 98:350-353. (In French.)
96. Reed, C., R. Bryant, A. S. Ibrahim, J. Edwards, Jr., S. G. Filler, R. Goldberg, and B. Spellberg. 2008. Combination polyene-caspofungin treatment of rhino-orbital-cerebral mucormycosis. Clin. Infect. Dis. 47:364-371.
97. Rees, J. R., R. W. Pinner, R. A. Hajjeh, M. E. Brandt, and A. L. Reingold. 1998. The epidemiological features of invasive mycotic infections in the San Francisco Bay area, 1992-1993: results of population-based laboratory active surveillance. Clin. Infect. Dis. 27:1138-1147.
98. Ribes, J. A., C. L. Vanover-Sams, and D. J. Baker. 2000. Zygomycetes in human disease. Clin. Microbiol. Rev. 13:236-301.
99. Rickerts, V., G. Just-Nubling, F. Konrad, J. Kern, E. Lambrecht, A. Bohme, V. Jacobi, and R. Bialek. 2006. Diagnosis of invasive aspergillosis and mucormycosis in immunocompromised patients by seminested PCR assay of tissue samples. Eur. J. Clin. Microbiol. Infect. Dis. 25:8-13.
100. Rickerts, V., S. Mousset, E. Lambrecht, K. Tintelnot, R. Schwerdtfeger, E. Presterl, V. Jacobi, G. Just-Nubling, and R. Bialek. 2007. Comparison of histopathological analysis, culture, and polymerase chain reaction assays to detect invasive mold infections from biopsy specimens. Clin. Infect. Dis. 44:1078-1083.
101. Roden, M. M., T. E. Zaoutis, W. L. Buchanan, T. A. Knudsen, T. A. Sarkisova, R. L. Schaufele, M. Sein, T. Sein, C. C. Chiou, J. H. Chu, D. P. Kontoyiannis, and T. J. Walsh. 2005. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin. Infect. Dis. 41:634-653.
102. Ruchel, R., and M. Schaffrinski. 1999. Versatile fluorescent staining of fungi in clinical specimens by using the optical brightener Blankophor. J. Clin. Microbiol. 37:2694-2696.
103. Safdar, A., S. O'Brien, and I. F. Kouri. 2004. Efficacy and feasibility of aerosolized amphotericin B lipid complex therapy in caspofungin breakthrough pulmonary zygomyco- sis. Bone Marrow Transplant. 34:467-468.
104. Schipper, M. A. A. 1976. On Mucor circinelloides, Mucor racemosus and related species. Stud. Mycol. 12:1-40.
105. Schipper, M. A. A. 1984. A revision of the genus Rhizopus. I. The Rhizopus stolonifer group and Rhizopus oryzae. Stud. Mycol. 25:1-19.
106. Schipper, M. A. A., and J. A. Stalpers. 1984. A revision of the genus Rhizopus. II. The Rhizopus microsporus group. Stud. Mycol. 25:30-34.
107. Schipper, M. A. A., and J. A. Stalpers. 2002. Zygomycetes. The order Mucorales, p. 67-125. In D. H. Howard (ed.), Pathogenic Fungi in Humans and Animals, 2nd ed. Marcel Dekker, New York, NY.
108. Schwarz, P., S. Bretagne, J. C. Gantier, D. Garcia-Hermoso, O. Lortholary, F. Dromer, and E. Dannaoui. 2006. Molecular identification of zygomycetes from culture and experimentally infected tissues. J. Clin. Microbiol. 44:340-349.
109. Schwarz, P., O. Lortholary, F. Dromer, and E. Dannaoui. 2007. Carbon assimilation profiles as a tool for identification of zygomycetes. J. Clin. Microbiol. 45:1433-1439.
110. Sharma, N. L., V. K. Mahajan, and P. Singh. 2003. Orofacial conidiobolomycosis due to Conidiobolus incongruus. Mycoses 46:137-140.
111. Singh, N., J. M. Aguado, H. Bonatti, G. Forrest, K. L. Gupta, N. Safdar, G. T. John, K. J. Pursell, P. Munoz, R. Patel, J. Fortun, P. Martin-Davila, B. Philippe, F. Philit, A. Tabah, N. Terzi, V. Chatelet, S. Kusne, N. Clark, E. Blumberg, M. B. Julia, A. Humar, S. Houston, C. Lass-Florl, L. Johnson, E. R. Dubberke, M. A. Barron, and O. Lortholary. 2009. Zygomycosis in solid organ transplant recipients: a prospective, matched case-control study to assess risks for disease and outcome. J. Infect. Dis. 200:1002-1011.
112. St.-Germain, G., and R. Summerbell. 1996. Identifying Filamentous Fungi. A Clinical Laboratory Handbook. Star Publishing Company, Belmont, CA.
113. Subcommittee on Antifungal Susceptibility Testing (AFST) of the ESCMID European Committee for Antimicrobial Susceptibility Testing (EUCAST), J. L. Rodriguez-Tudela, J. P. Donnelly, M. C. Arendrup, S. Arikan, F. Barchiesi, J. Bille, E. Chryssanthou, M. Cuenca-Estrella, E. Dannaoui, D. Denning, W. Fegeler, P. Gaustad, C. Lass-Florl, C. Moore, M. Richardson, A. Schmalreck, A. Velegraki, and P. E. Verweij. 2008. EUCAST technical note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia- forming moulds. Clin. Microbiol. Infect. 14:982-984.
114. Sun, H. Y., J. M. Aguado, H. Bonatti, G. Forrest, K. L. Gupta, N. Safdar, G. T. John, K. J. Pursell, P. Munoz, R. Patel, J. Fortun, P. Martin-Davila, B. Philippe, F. Philit, A. Tabah, N. Terzi, V. Chatelet, S. Kusne, N. Clark, E. Blumberg, M. B. Julia, A. Humar, S. Houston, C. Lass-Florl, L. Johnson, E. R. Dubberke, M. A. Barron, O. Lortholary, and N. Singh. 2009. Pulmonary zygomycosis in solid organ transplant recipients in the current era. Am. J. Transplant. 9:2166-2171.
115. Sun, Q. N., A. W. Fothergill, D. I. McCarthy, M. G. Rinaldi, and J. R. Graybill. 2002. In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes. Antimicrob. Agents Chemother. 46:1581-1582.
116. Sun, Q. N., L. K. Najvar, R. Bocanegra, D. Loebenberg, and J. R. Graybill. 2002. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed-mouse model. Antimicrob. Agents Chemother. 46:2310-2312.
117. Taylor, G. D., A. S. Sekhon, D. L. Tyrrell, and G. Goldsand. 1987. Rhinofacial zygomycosis caused by Conidiobolus coronatus: a case report including in vitro sensitivity to antimycotic agents. Am. J. Trop. Med. Hyg. 36:398-401.
118. Torres-Narbona, M., J. Guinea, J. Martinez-Alarcon, P. Munoz, I. Gadea, and E. Bouza. 2007. Impact of zygomy- cosis on microbiology workload: a survey study in Spain. J. Clin. Microbiol. 45:2051-2053.
119. Torres-Narbona, M., J. Guinea, J. Martinez-Alarcon, P. Munoz, T. Pelaez, and E. Bouza. 2008. Workload and clinical significance of the isolation of zygomycetes in a tertiary general hospital. Med. Mycol. 46:225-230.
120. Torres-Narbona, M., J. Guinea, J. Martinez-Alarcon, T. Pelaez, and E. Bouza. 2007. In vitro activities of amphotericin B, caspofungin, itraconazole, posaconazole, and voriconazole against 45 clinical isolates of zygomycetes: comparison of CLSI M38-A, Sensititre YeastOne, and the Etest. Antimicrob. Agents Chemother. 51:1126-1129.
121. Ullmann, A. J., J. H. Lipton, D. H. Vesole, P. Chandrasekar, A. Langston, S. R. Tarantolo, H. Greinix, W. Morais de Azevedo, V. Reddy, N. Boparai, L. Pedicone, H. Patino, and S. Durrant. 2007. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N. Engl. J. Med. 356:335-347.
122. Vitrat-Hincky, V., B. Lebeau, E. Bozonnet, D. Falcon, P. Pradel, O. Faure, A. Aubert, C. Piolat, R. Grillot, and H. Pelloux. 2009. Severe filamentous fungal infections after widespread tissue damage due to traumatic injury: six cases and review of the literature. Scand. J. Infect. Dis. 41:491-500.
123. Voight, K., E. Hoffman, E. Einax, M. Erckart, T. Papp, C. Vagvolgyi, and L. Olsson. 2009. Revision of the family structure of the Mucorales (Mucoromycotina, Zygomycetes) based on multigene-genealogies: phylogenetic analyses suggest a bigeneric Phycomycetaceae with Spinellus as sister group to Phycomyces, p. 313-332. In Y. Gherbawy, R. Mach, and M. Rai (ed.), Current Advances in Molecular Mycology. Nova Science Publishers, Inc., New York, NY.
124. Voigt, K., E. Cigelnik, and K. O'Donnell. 1999. Phylogeny and PCR identification of clinically important zygomycetes based on nuclear ribosomal-DNA sequence data. J. Clin. Microbiol. 37:3957-3964.
125. Voigt, K., and J. Wostemeyer. 2001. Phylogeny and origin of 82 zygomycetes from all 54 genera of the Mucorales and Mortierellales based on combined analysis of actin and translation elongation factor EF-1alpha genes. Gene 270:113-120.
126. Walker, S. D., R. V. Clark, C. T. King, J. E. Humphries, L. S. Lytle, and D. E. Butkus. 1992. Fatal disseminated Conidiobolus coronatus infection in a renal transplant patient. Am. J. Clin. Pathol. 98:559-564.
127. Walsh, T. J., and D. P. Kontoyiannis. 2008. What is the role of combination therapy in management of zygomycosis? Clin. Infect. Dis. 47:372-374.
128. Weitzman, I., S. Whittier, J. C. McKitrick, and P. Della-Latta. 1995. Zygospores: the last word in identification of rare or atypical zygomycetes isolated from clinical specimens. J. Clin. Microbiol. 33:781-783.
129. Yangco, B. G., J. I. Okafor, and D. TeStrake. 1984. In vitro susceptibilities of human and wild-type isolates of Basidiobolus and Conidiobolus species. Antimicrob. Agents Chemother. 25:413-416.
130. Zaoutis, T. E., E. Roilides, C. C. Chiou, W. L. Buchanan, T. A. Knudsen, T. A. Sarkisova, R. L. Schaufele, M. Sein, T. Sein, P. A. Prasad, J. H. Chu, and T. J. Walsh. 2007. Zygomycosis in children: a systematic review and analysis of reported cases. Pediatr. Infect. Dis. J. 26:723-727.
131. Zavasky, D. M., W. Samowitz, T. Loftus, H. Segal, and K. Carroll. 1999. Gastrointestinal zygomycotic infection caused by Basidiobolus ranarum: case report and review. Clin. Infect. Dis. 28:1244-1248.