Cell Salvage During Liver Transplantation for Hepatocellular Carcinoma: A Retrospective Analysis of Tumor Recurrence Following Irradiation of the Salvaged Blood

Transplantation Proceedings

Volumn 53, Issue 5, 2021, Pages 1639-1644

  Weller, Astrid ^a   Seyfried, Timo ^a   Ahrens, Norbert ^a   Baier Kleinhenz, Lucia ^a   Schlitt, Hans Jürgen ^a   Peschel, Georg ^b   Graf, Bernhard M ^a   Sinner, Barbara ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CORTICOSTEROID; FRESH FROZEN PLASMA; HEMOGLOBIN; PROPOFOL; ROCURONIUM; SUFENTANIL; THROMBOCYTE CONCENTRATE;

ADULT; ARTICLE; BLOOD SALVAGE; BLOOD TRANSFUSION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ERYTHROCYTE CONCENTRATE; FEMALE; HUMAN; HUMAN TISSUE; INCIDENCE; IRRADIATION; LIVER CELL CARCINOMA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MODEL FOR END STAGE LIVER DISEASE SCORE; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTHROMBIN TIME; RADIOFREQUENCY ABLATION; RETROSPECTIVE STUDY; STEATOHEPATITIS; TUMOR RECURRENCE; COMPARATIVE STUDY; LIVER TUMOR; SALVAGE THERAPY;

CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; INCIDENCE; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; RETROSPECTIVE STUDIES; SALVAGE THERAPY;

EID: 85105792016     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2021.03.025     Document Type: Article

References (46)

1. Sapisochin, G, Bruix, J, Liver transplantation for hepatocellular carcinoma: outcomes and novel surgical approaches. Nat Rev Gastroenterol Hepatol 14 (2017), 203–217.
2. Cleland, S, Corredor, C, Ye, JJ, Srinivas, C, McCluskey, SA, Massive haemorrhage in liver transplantation: Consequences, prediction and management. World J Tranplant 6 (2016), 291–305.
3. Tormey, CA, Hendrickson, JE, Transfusion-related red blood cell alloantibodies: induction and consequences. Blood 133 (2019), 1821–1830.
4. Delaney, M, Wendel, S, Bercovitz, RS, et al. Transfusion reactions: prevention, diagnosis, and treatment. Lancet 388 (2016), 2825–2836.
5. Carson, JL, Triulzi, DJ, Ness, PM, Indications for and adverse effects of red-cell transfusion. N Engl J Med 377 (2017), 1261–1272.
6. Reichert, B, Kaltenborn, A, Becker, T, Schiffer, M, Klempnauer, J, Schrem, H, Massive blood transfusion after the first cut in liver transplantation predicts renal outcome and survival. Langenbecks Arch Surg 399 (2014), 429–440.
7. de Boer, MT, Christensen, MC, Asmussen, M, et al. The impact of intraoperative transfusion of platelets and red blood cells on survival after liver transplantation. Anesth Analg 106 (2008), 32–44 table of contents.
8. Soubra, A, Zabell, JR, Adejoro, O, Konety, BR, Effect of perioperative blood transfusion on mortality for major urologic malignancies. Clin Genitourin Cancer 13 (2015), e173–e181.
9. Linder, BJ, Thompson, RH, Leibovich, BC, et al. The impact of perioperative blood transfusion on survival after nephrectomy for non-metastatic renal cell carcinoma (RCC). BJU Int 114 (2014), 368–374.
10. Upile, T, Jerjes, W, Mahil, J, Sudhoff, H, Hopper, C, Wright, A, Blood product transfusion and cancer prognosis. Clin Adv Hematol Oncol 7 (2009), 656–661.
11. Vamvakas, EC, Blajchman, MA, Transfusion-related immunomodulation (TRIM): an update. Blood Rev 21 (2007), 327–348.
12. Pinto, MA, Chedid, MF, Sekine, L, et al. Intraoperative cell salvage with autologous transfusion in liver transplantation. World J Gatrointest Sur 11 (2019), 11–18.
13. Donohue, CI, Mallett, SV, Reducing transfusion requirements in liver transplantation. World J Transplant 5 (2015), 165–182.
14. Lyon, TD, Ferroni, MC, Turner, RM 2nd, Jones, C, Jacobs, BL, Davies, BJ, Short-term outcomes of intraoperative cell saver transfusion during open partial nephrectomy. Urology 86 (2015), 1153–1158.
15. Zhai, B, Sun, XY, Controversy over the use of intraoperative blood salvage autotransfusion during liver transplantation for hepatocellular carcinoma patients. World J Gastroernterol 19 (2013), 3371–3374.
16. Oefelein, MG, Kaul, K, Herz, B, et al. Molecular detection of prostate epithelial cells from the surgical field and peripheral circulation during radical prostatectomy. J Urol 155 (1996), 238–242.
17. Hansen, E, Wolff, N, Knuechel, R, Ruschoff, J, Hofstaedter, F, Taeger, K, Tumor cells in blood shed from the surgical field. Arch Surg 130 (1995), 387–393.
18. Akbulut, S, Kayaalp, C, Yilmaz, M, et al. Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients. World J Gastroenterol 19 (2013), 1625–1631.
19. Han, S, Kim, G, Ko, JS, et al. Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma. Ann Surg 264 (2016), 339–343.
20. Liang, TB, Li, DL, Liang, L, et al. Intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: efficiency of leukocyte depletion filters in the removal of tumor cells. Transplantation 85 (2008), 863–869.
21. Bundesärztekammer, Beschluss der, über Erratum/Anpassungen der. Richtlinie zur Gewinnung von Blut und Blutbestandteilen und zur Anwendung von Blutprodukten (Richtlinie Hämotherapie). 2017, Bundesanzeiger 16: A-1396 / B-1152 / C-1136.
22. Zhang, FJ, Yang, JT, Tang, LH, et al. Effect of x-ray irradiation on hepatocarcinoma cells and erythrocytes in salvaged blood. Sci Rep, 7, 2017, 7995.
23. Brand, A, Immunological aspects of blood transfusions. Blood Rev 14 (2000), 130–144.
24. Ahrens, N, Pruss, A, Mayer, B, Genth, R, Kiesewetter, H, Salama, A, Association between alloantibody specificity and autoantibodies to red blood cells. Transfusion 48 (2008), 20–24.
25. Mason, DP, Little, SG, Nowicki, ER, et al. Temporal pattern of transfusion and its relation to rejection after lung transplantation. J Heart Lung Transplant 28 (2009), 558–563.
26. Sanz, C, Ghita, G, Franquet, C, Martinez, I, Pereira, A, Red-blood-cell alloimmunization and female sex predict the presence of HLA antibodies in patients undergoing liver transplant. Vox Sang 99 (2010), 261–266.
27. Bardyn, M, Tissot, JD, Prudent, M, Oxidative stress and antioxidant defenses during blood processing and storage of erythrocyte concentrates. Transfus Clin Biol 25 (2018), 96–100.
28. Yoshida, T, Prudent, M, D'Alessandro, A, Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus 17 (2019), 27–52.
29. Liu, L, Wang, Z, Jiang, S, et al. Perioperative allogenenic blood transfusion is associated with worse clinical outcomes for hepatocellular carcinoma: a meta-analysis. PLoS One, 8, 2013, e64261.
30. Carless, PA, Henry, DA, Moxey, AJ, O'Connell, D, Brown, T, Fergusson, DA, Cell salvage for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev, 2010, Cd001888.
31. Colwell, CW Jr., Beutler, E, West, C, Hardwick, ME, Morris, BA, Erythrocyte viability in blood salvaged during total joint arthroplasty with cement. J Bone Joint Surg Am 84 (2002), 23–25.
32. Massicotte, L, Thibeault, L, Beaulieu, D, Roy, JD, Roy, A, Evaluation of cell salvage autotransfusion utility during liver transplantation. HPB (Oxford) 9 (2007), 52–57.
33. Hansen, E, Knuechel, R, Altmeppen, J, Taeger, K, Blood irradiation for intraoperative autotransfusion in cancer surgery: demonstration of efficient elimination of contaminating tumor cells. Transfusion 39 (1999), 608–615.
34. Kumar, N, Zaw, AS, Kantharajanna, SB, Khoo, BL, Lim, CT, Thiery, JP, Metastatic efficiency of tumour cells can be impaired by intraoperative cell salvage process: truth or conjecture?. Transfus Med 27:Suppl 5 (2017), 327–334.
35. Hansen, E, Is intraoperative blood salvage really safe in cancer surgery?. Transfusion 52 (2012), 2723–2724 author reply 2724.
36. Wu, WW, Zhang, WY, Zhang, WH, et al. Survival analysis of intraoperative blood salvage for patients with malignancy disease: a PRISMA-compliant systematic review and meta-analysis. Medicine (Baltimore), 98, 2019, e16040.
37. Waters, JH, Yazer, M, Chen, YF, Kloke, J, Blood salvage and cancer surgery: a meta-analysis of available studies. Transfusion 52 (2012), 2167–2173.
38. Kumar, N, Chen, Y, Zaw, AS, et al. Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review. Lancet Oncol 15 (2014), e33–e41.
39. Kumar, N, Ahmed, Q, Lee, VK, Zaw, AS, Goy, R, Wong, HK, Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?. Eur Spine J 25 (2016), 3997–4007.
40. Valbonesi, M, Bruni, R, Lercari, G, Florio, G, Carlier, P, Morelli, F, Autoapheresis and intraoperative blood salvage in oncologic surgery. Transfus Sci 21 (1999), 129–139.
41. Araujo, RL, Pantanali, CA, Haddad, L, Rocha Filho, JA, D'Albuquerque, LA, Andraus, W, Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?. World J Gastrointest Surg 8 (2016), 161–168.
42. Kim, JM, Kim, GS, Joh, JW, et al. Long-term results for living donor liver transplant recipients with hepatocellular carcinoma using intraoperative blood salvage with leukocyte depletion filter. Transplant Int 26 (2013), 84–89.
43. Foltys, D, Zimmermann, T, Heise, M, et al. Liver transplantation for hepatocellular carcinoma–is there a risk of recurrence caused by intraoperative blood salvage autotransfusion?. European Surg Res 47 (2011), 182–187.
44. Muscari, F, Suc, B, Vigouroux, D, et al. Blood salvage autotransfusion during transplantation for hepatocarcinoma: does it increase the risk of neoplastic recurrence?. Transplant Int 18 (2005), 1236–1239.
45. Hansen, E, Failed evidence of tumour cell removal from salvaged blood after leucocyte depletion. Transfus Med 16 (2006), 213–214 author reply 215-6.
46. Gong, M, Yang, JT, Liu, YQ, et al. Irradiation can selectively kill tumor cells while preserving erythrocyte viability in a co-culture system. PLoS One, 10, 2015, e0127181.