What are the mechanisms underlying vaping-induced lung injury?

Journal of Clinical Investigation

Volumn 130, Issue 6, 2020, Pages 2754-2756

  Alexander, Laura E Crotty ^a,b   Bellinghausen, Amy L ^b   Eakin, Michelle N ^c  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL;

EPIDEMIC; HUMAN; INHALATION; LUNG INJURY; PRIORITY JOURNAL; PUBLIC POLICY; REVIEW; TOBACCO; VAPING; VAPING PRODUCT USE ASSOCIATED LUNG INJURY; ADVERSE EVENT; LUNG; METABOLISM; PATHOLOGY;

HUMANS; LUNG; LUNG INJURY; VAPING;

EID: 85085905348     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI138644     Document Type: Review

References (20)

1. Dai H, Leventhal AM. Prevalence of e-cigarette use among adults in the United States, 2014-2018. JAMA. 2019; 322(18):1824-1827.
2. Cullen KA, et al. e-Cigarette use among youth in the United States, 2019. JAMA. 2019; 322(21):2095-2103.
3. Chadi N, Schroeder R, Jensen JW, Levy S. Association between electronic cigarette use and marijuana use among adolescents and young adults: A systematic review and meta-analysis [published online August 12, 2019]. JAMA Pediatr. https://doi.org/10.1001/jamapediatrics. 2019.2574.
4. Perrine CG, et al. Characteristics of a Mulcharacterization tistate Outbreak of Lung Injury Associated with E-cigarette Use, or Vaping - United States, 2019. MMWR Morb Mortal Wkly Rep. 2019; 68(39):860-864.
5. Berlin I, Thomas D, Le Faou AL, Cornuz J. COVID-19 and smoking [published online April 3, 2020]. Nicotine Tob Res. https://doi. org/10.1093/ntr/ntaa059.
6. Johnson ER, Matthay MA. Acute lung injury: Epidemiology, pathogenesis, and treatment. J Aerosol Med Pulm Drug Deliv. 2010; 23(4):243-252.
7. Harrell MB, et al. Flavored e-cigarette use: Characterizing youth, young adult, and adult users. Prev Med Rep. 2017; 5:33-40.
8. Leventhal AM, et al. Flavored E-cigarette use and progression of vaping in adolescents. Pediatrics. 2019; 144(5):e20190789.
9. Villanti AC, et al. Association of flavored tobacco use with tobacco initiation and subsequent use among US youth and adults, 2013-2015. JAMA Netw Open. 2019; 2(10):e1913804.
10. Allen JG, et al. Flavoring chemicals in E-cigarettes: Diacetyl, 2, 3-pentanedione, and acetoin in a sample of 51 products, including fruit-, candy-, and cocktail-flavored E-cigarettes. Environ Health Perspect. 2016; 124(6):733-739.
11. Lee DC, Crosier BS, Borodovsky JT, Sargent JD, Budney AJ. Online survey characterizing vaporizer use among cannabis users. Drug Alcohol Depend. 2016; 159:227-233.
12. Kanwal R. Bronchiolitis obliterans in workers exposed to flavoring chemicals. Curr Opin Pulm Med. 2008; 14(2):141-146.
13. Harber P, Saechao K, Boomus C. Diacetylinduced lung disease. Toxicol Rev. 2006; 25(4):261-272.
14. Crotty Alexander LE, Shin S, Hwang JH. Inflammatory diseases of the lung induced by conventional cigarette smoke: A review. Chest. 2015; 148(5):1307-1322.
15. Arter ZL, Wiggins A, Hudspath C, Kisling A, Hostler DC, Hostler JM. Acute eosinophilic pneumonia following electronic cigarette use. Respir Med Case Rep. 2019; 27:100825.
16. Layden JE, et al. Pulmonary illness related to E-Cigarette use in Illinois and Wisconsin - Final Report. N Engl J Med. 2020; 382(10):903-916.
17. White CW, Martin JG. Chlorine gas inhalation: Human clinical evidence of toxicity and experience in animal models. Proc Am Thorac Soc. 2010; 7(4):257-263.
18. Li W, Pauluhn J. Phosgene-induced acute lung injury (ALI): Differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine. Clin Transl Med. 2017; 6(1):19.
19. Blount BC, et al. Evaluation of bronchoalveolar lavage fluid from patients in an outbreak of E-cigarette, or vaping, product use-associated lung injury - 10 states, August-October 2019. MMWR Morb Mortal Wkly Rep. 2019; 68(45):1040-1041.
20. Crotty Alexander LE, et al. NIH workshop report: E-cigarette or vaping product use associated lung injury (EVALI): Developing a research agenda [published online April 3, 2020]. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.201912-2332ws.