Temporal dynamics in viral shedding and transmissibility of COVID-19

Nature Medicine

Volumn 26, Issue 5, 2020, Pages 672-675

  He, Xi ^a   Lau, Eric H Y ^b   Wu, Peng ^b   Deng, Xilong ^a   Wang, Jian ^a   Hao, Xinxin ^b   Lau, Yiu Chung ^b   Wong, Jessica Y ^b   Guan, Yujuan ^a   Tan, Xinghua ^a   Mo, Xiaoneng ^a   Chen, Yanqing ^a   Liao, Baolin ^a   Chen, Weilie ^a   Hu, Fengyu ^a   Zhang, Qing ^a   Zhong, Mingqiu ^a   Wu, Yanrong ^a   Zhao, Lingzhai ^a   Zhang, Fuchun ^a   Cowling, Benjamin J ^b   Li, Fang ^a   Leung, Gabriel M ^b   more..

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; CORONAVIRUS DISEASE 2019; DISEASE CONTROL; DISEASE SEVERITY; DISEASE TRANSMISSION; FEMALE; HUMAN; INCUBATION TIME; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROAT CULTURE; VIRUS LOAD; VIRUS SHEDDING; BETACORONAVIRUS; CORONAVIRUS INFECTION; PANDEMIC; PHYSIOLOGY; VIRUS PNEUMONIA;

BETACORONAVIRUS; CORONAVIRUS INFECTIONS; HUMANS; PANDEMICS; PNEUMONIA, VIRAL; VIRUS SHEDDING;

EID: 85083513005     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-020-0869-5     Document Type: Article

References (17)

1. Li, Q. et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N. Engl. J. Med. 382, 1199–1207 (2020).
2. Wu, J. T., Leung, K. & Leung, G. M. Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study. Lancet 395, 689–697 (2020).
3. Peiris, J. S. et al. Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet 361, 1767–1772 (2003).
4. Pitzer, V. E., Leung, G. M. & Lipsitch, M. Estimating variability in the transmission of severe acute respiratory syndrome to household contacts in Hong Kong, China. Am. J. Epidemiol. 166, 355–363 (2007).
5. Riley, S. et al. Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions. Science 300, 1961–1966 (2003).
6. Ip, D. K. et al. Viral shedding and transmission potential of asymptomatic and paucisymptomatic influenza virus infections in the community. Clin. Infect. Dis. 64, 736–742 (2017).
7. Ganyani, T. et al. Estimating the generation interval for COVID-19 based on symptom onset data. Preprint at medRxiv 10.1101/2020.03.05.20031815 (2020).
8. Zou, L. et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. N. Engl. J. Med. 382, 1177–1179 (2020).
9. To, K.K.-W. et al. Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study. Lancet Infect. Dis. https://doi.org/10.1016/S1473-3099(20)30196-1 (2020).
10. Zhou, F. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395, 1054–1062 (2020).
11. Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Nature https://doi.org/10.1038/s41586-020-2196-x (2020).
12. Tsang, T. K. et al. Influenza A virus shedding and infectivity in households. J. Infect. Dis. 212, 1420–1428 (2015).
13. Bai, Y. et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA https://doi.org/10.1001/jama.2020.2565 (2020).
14. Tong, Z. D. et al. Potential presymptomatic transmission of SARS-CoV-2, Zhejiang Province, China, 2020. Emerg. Infect. Dis. https://doi.org/10.3201/eid2605.200198 (2020).
15. Hellewell, J. et al. Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts. Lancet Glob. Health 8, e488–e496 (2020).
16. Nishiura, H., Linton, N. M. & Akhmetzhanov, A. R. Serial interval of novel coronavirus (COVID-19) infections. Int. J. Infect. Dis. 93, 284–286 (2020).
17. Chen, W. et al. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerg. Microbes Infect. 9, 469–473 (2020).