Considerations on the applicability of OECD TG 453 to whole food/feed testing

EFSA Journal

Volumn 11, Issue 7, 2013, Pages

[No Author Info available]

Author keywords

2 year feeding study; carcinogenicity; chronic toxicity; experimental design; statistical analysis; whole food feed

Indexed keywords

EID: 85078366926     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2013.3347     Document Type: Article

References (13)

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3. EFSA Panel on Genetically Modified Organisms (GMO), 2011. Guidance for risk assessment of food and feed from genetically modified plants. EFSA Journal 2011;9(5):2150, 37 pp. doi: 10.2903/j.efsa.2011.2150.
4. EFSA Scientific Committee, 2011a. EFSA guidance on conducting repeated-dose 90-day oral toxicity study in rodents on whole food/feed. EFSA Journal 2011;9(12):2438, 21 pp. doi:10.2903/j.efsa.2011.2438.
5. EFSA Scientific Committee, 2011b. Statistical Significance and Biological Relevance. EFSA Journal 2011;9(9):2372, 17 pp. doi:10.2903/j.efsa.2011.2372.
6. FAO/WHO (Food and Agriculture Organization of the United Nations/World Health Organization), 2000. Safety aspects of genetically modified foods of plant origin. Report of a Joint FAO/WHO Expert Consultation on Foods Derived from Biotechnology, 29 May - 2 June 2000 Geneva, Switzerland.
7. OECD (Organisation for Economic Co-operation and Development), 1998. Repeated Dose 90-Day Oral Toxicity Study in Rodents. Test Guideline No. 408, Guidelines for the Testing of Chemicals, OECD, Paris.
8. OECD (Organisation for Economic Co-operation and Development), 2000. Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation. Series on Testing and Assessment No. 19, OECD, Paris.
9. OECD (Organisation for Economic Co-operation and Development), 2008. Repeated Dose 28-day Oral Toxicity Study in Rodents. Test Guideline No. 407, Guidelines for the Testing of Chemicals, OECD, Paris.
10. OECD (Organisation for Economic Co-operation and Development), 2009a. Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing.
11. OECD (Organisation for Economic Co-operation and Development), 2009b. Test No. 452: Chronic Toxicity Studies, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing.
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13. OECD (Organisation for Economic Co-operation and Development), 2012. Guidance document 116 on the conduct and design of chronic toxicity and carcinogenicity studies, supporting test guidelines 451, 452 and 453, 2nd edition, OECD, Paris.