Scientific Opinion on the substantiation of a health claim related to beta-palmitate and contribution to softening of stools pursuant to Article 14 of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 12, Issue 2, 2014, Pages

[No Author Info available]

Author keywords

beta palmitate; health claims; infant formula; stools

Indexed keywords

EID: 85077942733     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2014.3578     Document Type: Article

References (21)

1. Bongers ME, de Lorijn F, Reitsma JB, Groeneweg M, Taminiau JA and Benninga MA, 2007. The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. Nutrition Journal, 6, 8.
2. Carnielli VP, Luijendijk IH, van Goudoever JB, Sulkers EJ, Boerlage AA, Degenhart HJ and Sauer PJ, 1995. Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance. American Journal of Clinical Nutrition, 61, 1037–1042.
3. Carnielli VP, Luijendijk IH, Van Goudoever JB, Sulkers EJ, Boerlage AA, Degenhart HJ and Sauer PJ, 1996. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. Journal of Pediatric Gastroenterology and Nutrition, 23, 553–560.
4. Chevallier B, Fournier V, Logre B, Beck L, Ceccato F, Hui Bon Hoa G, Lachambre E, Van Egroo LD and Sznajder M, 2009. Intérêt d'une nouvelle préparation infantile dans la prise en charge des régurgitations du nourrisson: Value of a new thickened formula in infants with regurgitations. Archives de Pédiatrie, 16, 343–352.
5. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), 2011. Scientific Opinion on the substantiation of a health claim related to beta-palmitate and increased calcium absorption pursuant to Article 14 of Regulation (EC) No 1924/2006. EFSA Journal 2011;9(7):2289,16 pp. doi:10.2903/j.efsa.2011.2289
6. Enzymotec Ltd, unpublished. Comparative study of synthetically structured triglycerides efficacy on fatty acid absorption in weanling rats.
7. de Fouw NJ, Kivits GA, Quinlan PT and van Nielen WG, 1994. Absorption of isomeric, palmitic acid-containing triacylglycerols resembling human milk fat in the adult rat. Lipids, 29, 765–770.
8. Innis SM and Dyer R, 1997. Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-fed piglets. Journal of Nutrition, 127, 1311–1319.
9. Innis SM, Dyer R and Nelson CM, 1994. Evidence that palmitic acid is absorbed as sn-2 monoacylglycerol from human milk by breast-fed infants. Lipids, 29, 541–545.
10. Innis SM, Dyer RA and Lien EL, 1997. Formula containing randomized fats with palmitic acid (16:0) in the 2-position increases 16:0 in the 2-position of plasma and chylomicron triglycerides in formula-fed piglets to levels approaching those of piglets fed sow's milk. Journal of Nutrition, 127, 1362–1370.
11. Kennedy K, Fewtrell MS, Morley R, Abbott R, Quinlan PT, Wells JC, Bindels JG and Lucas A, 1999. Double-blind, randomized trial of a synthetic triacylglycerol in formula-fed term infants: effects on stool biochemistry, stool characteristics, and bone mineralization. American Journal of Clinical Nutrition, 70, 920–927.
12. Koo WW, Hockman EM and Dow M, 2006. Palm olein in the fat blend of infant formulas: effect on the intestinal absorption of calcium and fat, and bone mineralization. Journal of the American College of Nutrition, 25, 117–122.
13. Lien EL, Boyle FG, Yuhas R, Tomarelli RM and Quinlan P, 1997. The effect of triglyceride positional distribution on fatty acid absorption in rats. Journal of Pediatric Gastroenterology and Nutrition, 25, 167–174.
14. Litmanovitz I, Bar-Yoseph F, Lifshitz Y, Davidson K, Eliakim A, Regev RH, and Nemet D, 2013 (unpublished). Reduced crying in term infants fed with sn-2-palmitate infant-formula: a double-blind, randomised, clinical trial.
15. Litmanovitz I, Davidson K, Eliakim A, Regev RH, Dolfin T, Arnon S, Bar-Yoseph F, Goren A, Lifshitz Y and Nemet D, 2013. High Beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcified Tissue International, 92, 35–41.
16. Lopez-Lopez A, Castellote-Bargallo AI, Campoy-Folgoso C, Rivero-Urgel M, Tormo-Carnice R, Infante-Pina D and Lopez-Sabater MC, 2001. The influence of dietary palmitic acid triacylglyceride position on the fatty acid, calcium and magnesium contents of at term newborn faeces. Early Human Development, 65 Suppl, S83–94.
17. Lucas A, Quinlan P, Abrams S, Ryan S, Meah S and Lucas PJ, 1997. Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants. Archives of Disease in Childhood. Fetal and Neonatal Edition, 77, F178–184.
18. Miró F, Santamaría A, Soriano V, Masseguer X, Prandi F and Rivero M, 2001. Poster based in a clinical observational trial: effectiveness of beta-palmitate on the improvement of constipation in infants. XV National Congress of Extra-hospital Paediatric Society of the Spanish Paediatric Association (AEP), Zaragoza, Spain.
19. Nelson CM and Innis SM, 1999. Plasma lipoprotein fatty acids are altered by the positional distribution of fatty acids in infant formula triacylglycerols and human milk. American Journal of Clinical Nutrition, 70, 62–69.
20. Quinlan PT, Lockton S, Irwin J and Lucas AL, 1995. The relationship between stool hardness and stool composition in breast- and formula-fed infants. Journal of Pediatric Gastroenterology and Nutrition, 20, 81–90.
21. Sanders DJ, Howes D and Earl LK, 2001. The absorption, distribution and excretion of 1- and 2-[14C]palmitoyl triacyglycerols in the rat. Food and Chemical Toxicology, 39, 709–716.