Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-fed piglets

Journal of Nutrition

Volumn 127, Issue 7, 1997, Pages 1311-1319

  Innis, Sheila M ^a   Dyer, Roger ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Formula fatty acids; Milk fatty acids; Palmitic acid; Piglets; Triglyceride structure

Indexed keywords

ARACHIDONIC ACID; CHOLESTEROL ESTER; CHYLOMICRON; DOCOSAHEXAENOIC ACID; PALMITIC ACID; TRIACYLGLYCEROL;

ARTICLE; ARTIFICIAL MILK; FAT INTAKE; FOOD COMPOSITION; LIPID COMPOSITION; LIPID METABOLISM; LIPID TRANSPORT; SWINE;

SUS SCROFA;

EID: 0030788334     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.7.1311     Document Type: Article

References (40)

1. Barnes, L. A., Morrow, G., Silverio, J., Finnegan, L. P. & Haitman, S. C. (1974) Calcium and fat absorption from Infant formulas with different fat blends. Pediatrics 54: 217-221.
2. Bernback, S., Blackberg, L. & Hernell, O. (1990) The complete digestion of human milk triacylglycerol in vitro requires gastric lipase, pancreatic colipase-dependent lipase, and bile salt-stimulated lipase. J. Clin. Invest. 85: 1221-1226.
3. Breckenridge, W. C., Marai, L. & Kuksis, A. (1969) Triglyceride structure of human milk fat. Can. J. Biochem. 47: 761-769.
4. Carnielli, V. P., Luijendijk, I.H.T, van Seek, R.H.T., Boerma, C.J.M., Degenhast, H. J. & Sauer, P.J.J. (1995) Effect of dietary triacylglycerol fatty acid positional distribution in plasma lipid classes and their fatty acid composition in preterm infants. Am. J. Clin. Nutr. 62: 776-781.
5. Christie, U. W. & Clapperton, J. L. (1982) Structures of cow's milk, fortified milks (including infant formulae), and human milk. J. Soc. Dairy Technol. 35: 22-28
6. Filer, L. J., Jr., Mattson, F. H. & Fomon, S. J. (1969) Triglyceride configuration and fat absorption in the human infant. J. Nutr. 99: 293-298.
7. Gidez, L. I., Miller, G. J., Burstein, M., Slagele, S. & Eder, H. A. (1982) Separation and quantitation of subclasses of human plasma high density lipoproteins by a simple precipitation procedure. J. Lipid Res. 23: 1206-1223.
8. Glomset, J. A. (1979) Lecithin: cholesterol acyltransferase. An exercise in comparative biology. Prog. Biochem. Pharmacol. 15: 41-66.
9. Grove, D. & Parnall, H. J. (1991) Comparative specificity of plasma lecithin: cholesterol acyltransferase from the animal species. Lipids 26: 416-420.
10. Holub, B. J., Bakker, D. J. & Skeaff, C. M. (1987) Alterations in molecular species of cholesterol esters formed via plasma lecithin-cholesterol acyltransferase in humans consuming fish oil. Atherosclerosis 66: 11-28.
11. Hrboticky, N., MacKinnon, M. J., Puterman, M. L. & Innis, S. M. (1990) Effect of a vegetable oil formula rich in linoleic acid on tissue fatty acid accretion in the brain, liver, plasma and erythrocytes of infant piglets. Am. J. Clin. Nutr. 51: 173-182.
12. Illigsworth, D. R., Harris, W. S. & Connor, W. E. (1984) Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis 4: 270-275.
13. Innis, S. M., Dyer, R. & Nelson, C. M. (1994a) Evidence that palmitic acid is absorbed as sn-2 monoacylglycerol from human milk by breast-fed infants. Lipids 29: 541-545.
14. Innis, S. M., Dyer, R., Quinlan, P. & Diersen-Schade, D. (1995) Palmitic acid is absorbed as sn-2 monopalmitin from milk and formula with rearranged triacylglycerols and results in increased plasma triglyceride sn-2 and cholesteryl ester palmitate in piglets. J. Nutr. 125: 73-81.
15. Innis, S. M., Nelson, C. M., Rioux, F. M. & King, D. J. (1994b) Development of visual aculty in relation to plasma and erythrocyte ω-6 and ω-3 fatty acids in healthy term gestation Infants. Am. J. Clin. Nutr. 60: 347-352.
16. Innis, S. M., Quinlan, P. & Diersen-Schade, D. (1993) Saturated fatty acid chain length and positional distribution in infant formula: effects on growth and plasma lipids and ketones in piglets. Am. J. Clin. Nutr. 57: 382-390.
17. Jensen, C., Buist, N.R.M. & Wilson, T. (1986) Absorption of individual fatty acids from long chain or medium chain triglycerides in very small infants. Am. J. Clin. Nutr. 43: 745-751.
18. Jensen, R. G. (1989) Lipids in human milk - composition and fat-soluble vitamins. In: Textbook of Gastroenterology and Nutrition in Infancy (Lebenthal E, ed.), 2nd ed., pp. 157-208. Raven Press, New York, NY.
19. Jones, P.J.H., Hrboticky, N., Hahn, P. & Innis, S. M. (1990) Comparison of breast and formula feeding on intestinal and hepatic cholesterol metabolism in the neonatal pig. Am. J. Clin. Nutr. 51: 979-984.
20. Lepage, G. & Roy, C. C. (1987) Direct transesterification of classes of lipids in a one-step reaction. J. Lipid Res. 27: 114-120.
21. Lui, M., Bagdade, J. D. & Subbaiah, P. V. (1995) Specificity of lecithin: cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species. J. Lipid Res. 36: 1813-1824.
22. Maguire, G., Lee, M. & Connelly, P. W. (1989) Sodium dodecyl sulfate-glycerol polyacrylamide gel slab electrophoresis for the resolution of apolipoprotein. J. Lipid Res. 30: 757-761.
23. Makrides, M., Simmer, K., Goggin, M. & Gibson, R. A. (1993) Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. Pediatr. Res. 34: 425-427.
24. Martin, J.-C., Bougnoux, P. Antoine, J.-M., Lanson, M. & Clouet, C. (1993) Triacylglycerol structure of human colostrum and mature milk. Lipids 28: 630-643.
25. Mattson, F. H. & Lutton, E. S. (1958) The specific distribution of fatty acids in the glycerides of animal and vegetable fats. J. Biol. Chem. 233: 868-871.
26. Mortimer, B. C., Kenrick, M. A., Holthouse, D. J., Stick, R. V. & Regrave, T. G. (1992) Plasma clearance of model lipoprotetns containing saturated and poyunsaturated monoacylglycerols injected intravenously in the rat. Biochim. Biophys. Acta 1127: 67-73.
27. Myher, J. J., Kuksis, A., Breckenridge, W. C., McGuire, V. & Little, J. A. (1985) Comparative studies of triacylglycerol structure of very low density lipoproteins and chylomicrons of normolipemic subjects and patients with type II hyperlipoproteinemia. Lipids 20: 90-101.
28. Parks, J. S., Bullock, B. C. & Rudel, L. L. (1989) The reactivity of plasma phospholipids with lecithin:cholesterol acyltransferase is decreased in fish oil-fed monkeys. J. Biol. Chem. 264: 2545-2551.
29. Parodi, P. W. (1982) Positional distribution of fatty acids in triglycerides from milk of several species of mammals. Lipids 17: 437-442.
30. Ponder, D. L., Innis, S. M., Benson, J. D. & Siegman, J. S. (1992) Docosahexaenoic acid status of term infants fed breast milk, or Infant formula containing soy oil or corn oil. Pediatr. Res. 32: 683-688.
31. Redgrave, T. G., Kodali, D. R. & Small, D. M. (1988) The effect of triacyl-sn-glycerol structure on the metabolism of chylomicrons and the triacylglycerolrich emulsions in the rat. J. Biol. Chem. 263: 5118-5123.
32. Redgrave, T. G., Roberts, D.C.K. & West, C. E. (1975) Separation of plasma lipoproteins by density gradient ultracentrifugation. Anal. Biochem. 65: 42-49.
33. Small, D. M. (1991) The effects of glyceride structure on absorption and metabolism. Annu. Rev. Nutr. 11: 413-434.
34. Subbaiah, P. V., Kaufman, D. & Bagdade, J. H. (1993) Incorporation of dietary n-3 fatty acids into molecular species of phosphatidyl choline and cholesteryl ester in normal human plasma. Am. J. Clin. Nutr. 58: 360-368.
35. Subbaiah, P. V., Liu, M., Bolan, P. J. & Paltauf, F. (1992) Altered positional specificity of human plasma lecithin-cholesterol acyltransferase in the presence of sn-2 arachidonoyl phosphatidyl cholines. Mechanism of formation of saturated cholesteryl esters. Biochim. Biophys. Acta 1128: 83-92.
36. Subbaiah, P. V. & Monshizadegan, H. (1988) Substrate specificity of human plasma lecithin-cholesterol acyltransferase towards molecular species of phosphatidylcholine in native plasma. Biochim. Biophys. Acta. 963: 445-455.
37. Tomarelli, R. M., Meyer, B. J., Weaber, J. R. & Bernhart, F. W. (1968) Effect of positional distribution on the absorption of the fatty acids of human milk and infant formulas. J. Nutr. 95: 583-590.
38. Yang, L. Y. & Kuksis, A. (1991) Apparent convergence (at 2-monoacylglycerol level) of phosphatidic acid and 2-monoacylglycerol pathways of synthesis of chylomicron triacylglycerols. J. Lipid Res. 232: 1173-1186.
39. Zock, P. L., de Vries, J.H.M., de Fouw, N. J. & Katan, M. B. (1995) Positional distribution of fatty acids in dietary triglycerides: effects in fasting blood lipoprotein concentrations in humans. Am. J. Clin. Nutr. 61: 48-55.
40. Zock, P. L., Gerritsen, J. & Katan, M. B. (1996) Partial conservation of the sn-2 position of dietary triglycerides in fasting plasma lipids in humans. Eur. J. Clin. Invest. 26: 141-150.