메뉴 건너뛰기




Volumn 8, Issue 1, 2020, Pages 57-66

Mediators of the Effects of Canagliflozin on Heart Failure in Patients With Type 2 Diabetes

(11)  Li, JingWei a,b,c   Woodward, Mark c,d,e   Perkovic, Vlado c   Figtree, Gemma A f,g   Heerspink, Hiddo J L c,h   Mahaffey, Kenneth W i   de Zeeuw, Dick h   Vercruysse, Frank j   Shaw, Wayne k   Matthews, David R l   Neal, Bruce c,m,n  


Author keywords

canagliflozin; heart failure; mediation analysis; renal outcomes

Indexed keywords

ALBUMIN; BICARBONATE; CANAGLIFLOZIN; CREATININE; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; SERUM ALBUMIN; URATE;

EID: 85076595299     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2019.08.004     Document Type: Article
Times cited : (110)

References (32)
  • 1
    • 84944800184 scopus 로고    scopus 로고
    • Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes
    • Zinman, B., Wanner, C., Lachin, J., et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med 373 (2015), 2117–2128.
    • (2015) N Engl J Med , vol.373 , pp. 2117-2128
    • Zinman, B.1    Wanner, C.2    Lachin, J.3
  • 2
    • 85034766786 scopus 로고    scopus 로고
    • Canagliflozin and cardiovascular and renal events in type 2 diabetes
    • Neal, B., Perkovic, V., Mahaffey, K.W., et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes. N Engl J Med 377 (2017), 644–657.
    • (2017) N Engl J Med , vol.377 , pp. 644-657
    • Neal, B.1    Perkovic, V.2    Mahaffey, K.W.3
  • 3
    • 84941243068 scopus 로고    scopus 로고
    • Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
    • Ferrannini, E., DeFronzo, R.A., Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J 36 (2015), 2288–2296.
    • (2015) Eur Heart J , vol.36 , pp. 2288-2296
    • Ferrannini, E.1    DeFronzo, R.A.2
  • 4
    • 85003855318 scopus 로고    scopus 로고
    • Renal, metabolic and cardiovascular considerations of SGLT2 inhibition
    • DeFronzo, R.A., Norton, L., Abdul-Ghani, M., Renal, metabolic and cardiovascular considerations of SGLT2 inhibition. Nat Rev Nephrol 13 (2017), 11–26.
    • (2017) Nat Rev Nephrol , vol.13 , pp. 11-26
    • DeFronzo, R.A.1    Norton, L.2    Abdul-Ghani, M.3
  • 5
    • 84914154997 scopus 로고    scopus 로고
    • Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus
    • Sha, S., Polidori, D., Heise, T., et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab 16 (2014), 1087–1095.
    • (2014) Diabetes Obes Metab , vol.16 , pp. 1087-1095
    • Sha, S.1    Polidori, D.2    Heise, T.3
  • 6
    • 85006792228 scopus 로고    scopus 로고
    • Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation
    • Hayes, A.F., Rockwood, N.J., Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation. Behav Res Ther 98 (2017), 39–57.
    • (2017) Behav Res Ther , vol.98 , pp. 39-57
    • Hayes, A.F.1    Rockwood, N.J.2
  • 7
  • 8
    • 85041180129 scopus 로고    scopus 로고
    • How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial
    • Inzucchi, S.E., Zinman, B., Fitchett, D., et al. How does empagliflozin reduce cardiovascular mortality? Insights from a mediation analysis of the EMPA-REG OUTCOME trial. Diabetes Care 41 (2018), 356–363.
    • (2018) Diabetes Care , vol.41 , pp. 356-363
    • Inzucchi, S.E.1    Zinman, B.2    Fitchett, D.3
  • 9
    • 84880924263 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)—a randomized placebo-controlled trial
    • Neal, B., Perkovic, V., de Zeeuw, D., et al. Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)—a randomized placebo-controlled trial., 166, 2013, 217–223.
    • (2013) , vol.166 , pp. 217-223
    • Neal, B.1    Perkovic, V.2    de Zeeuw, D.3
  • 10
    • 85013890365 scopus 로고    scopus 로고
    • Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study–Renal (CANVAS-R): a randomized, placebo-controlled trial
    • Neal, B., Perkovic, V., Matthews, D.R., et al. Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study–Renal (CANVAS-R): a randomized, placebo-controlled trial. Diabetes Obes Metab 19 (2017), 387–393.
    • (2017) Diabetes Obes Metab , vol.19 , pp. 387-393
    • Neal, B.1    Perkovic, V.2    Matthews, D.R.3
  • 11
    • 34247502814 scopus 로고    scopus 로고
    • Mediators and mechanisms of change in psychotherapy research
    • Kazdin, A.E., Mediators and mechanisms of change in psychotherapy research. Annu Rev Clin Psychol 3 (2007), 1–27.
    • (2007) Annu Rev Clin Psychol , vol.3 , pp. 1-27
    • Kazdin, A.E.1
  • 12
    • 84964995997 scopus 로고    scopus 로고
    • Your “survival” guide to using time-dependent covariates. Proceedings of the SAS Global Forum. 2012:22–25
    • Available at: (Accessed 26 August 2019)
    • Powell, T.M., Bagnell, M.E., Your “survival” guide to using time-dependent covariates. Proceedings of the SAS Global Forum. 2012:22–25. Available at: https://support.sas.com/resources/papers/proceedings12/168-2012.pdf. (Accessed 26 August 2019)
    • Powell, T.M.1    Bagnell, M.E.2
  • 13
    • 70849134693 scopus 로고    scopus 로고
    • “Proportion explained”: a causal interpretation for standard measures of indirect effect?
    • Hafeman, D.M., “Proportion explained”: a causal interpretation for standard measures of indirect effect?. Am J Epidemiol 170 (2009), 1443–1448.
    • (2009) Am J Epidemiol , vol.170 , pp. 1443-1448
    • Hafeman, D.M.1
  • 14
    • 84923995264 scopus 로고    scopus 로고
    • SAS macro for causal mediation analysis with survival data
    • Valeri, L., VanderWeele, T.J., SAS macro for causal mediation analysis with survival data. Epidemiology 26 (2015), e23–e24.
    • (2015) Epidemiology , vol.26 , pp. e23-e24
    • Valeri, L.1    VanderWeele, T.J.2
  • 15
    • 85053799675 scopus 로고    scopus 로고
    • Multiple mediation analysis with survival outcomes: with an application to explore racial disparity in breast cancer survival
    • Yu, Q., Wu, X., Li, B., Scribner, R.A., Multiple mediation analysis with survival outcomes: with an application to explore racial disparity in breast cancer survival. Stat Med 38 (2019), 398–412.
    • (2019) Stat Med , vol.38 , pp. 398-412
    • Yu, Q.1    Wu, X.2    Li, B.3    Scribner, R.A.4
  • 16
    • 85032620814 scopus 로고    scopus 로고
    • Effects of sodium-glucose co-transporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action
    • Packer, M., Anker, S.D., Butler, J., Filippatos, G., Zannad, F., Effects of sodium-glucose co-transporter 2 inhibitors for the treatment of patients with heart failure: proposal of a novel mechanism of action. JAMA Cardiol 2 (2017), 1025–1029.
    • (2017) JAMA Cardiol , vol.2 , pp. 1025-1029
    • Packer, M.1    Anker, S.D.2    Butler, J.3    Filippatos, G.4    Zannad, F.5
  • 17
    • 0242654867 scopus 로고    scopus 로고
    • Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectiviely-designed overviews of randomised trials
    • Turbull, F., Blood Pressure Lowering Treatment Trialists' Collaboration. Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectiviely-designed overviews of randomised trials. Lancet 362 (2003), 1527–1535.
    • (2003) Lancet , vol.362 , pp. 1527-1535
    • Turbull, F.1
  • 18
    • 84947998361 scopus 로고    scopus 로고
    • Effect of canagliflozin on liver function tests in patients with type 2 diabetes
    • Leiter, L., Forst, T., Polidori, D., Balis, D., Xie, J., Sha, S., Effect of canagliflozin on liver function tests in patients with type 2 diabetes. Diabetes Metab 42 (2016), 25–32.
    • (2016) Diabetes Metab , vol.42 , pp. 25-32
    • Leiter, L.1    Forst, T.2    Polidori, D.3    Balis, D.4    Xie, J.5    Sha, S.6
  • 19
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat, K., Kleiner, D.E., Niemeier, H.M., et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 51 (2010), 121–129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 20
    • 85019367291 scopus 로고    scopus 로고
    • Increased hematocrit during sodium-glucose co-transporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys
    • Sano, M., Takei, M., Shiraishi, Y., Suzuki, Y., Increased hematocrit during sodium-glucose co-transporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res 8 (2016), 844–847.
    • (2016) J Clin Med Res , vol.8 , pp. 844-847
    • Sano, M.1    Takei, M.2    Shiraishi, Y.3    Suzuki, Y.4
  • 21
    • 84880850027 scopus 로고    scopus 로고
    • Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes
    • Lambers Heerspink, H.J., De Zeeuw, D., Wie, L., Leslie, B., List, J., Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab 15 (2013), 853–862.
    • (2013) Diabetes Obes Metab , vol.15 , pp. 853-862
    • Lambers Heerspink, H.J.1    De Zeeuw, D.2    Wie, L.3    Leslie, B.4    List, J.5
  • 22
    • 84975840750 scopus 로고    scopus 로고
    • Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis
    • Mudaliar, S., Alloju, S., Henry, R.R., Can a shift in fuel energetics explain the beneficial cardiorenal outcomes in the EMPA-REG OUTCOME study? A unifying hypothesis. Diabetes Care 39 (2016), 1115–1122.
    • (2016) Diabetes Care , vol.39 , pp. 1115-1122
    • Mudaliar, S.1    Alloju, S.2    Henry, R.R.3
  • 24
    • 85031924469 scopus 로고    scopus 로고
    • Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study
    • Solini, A., Giannini, L., Seghieri, M., et al. Dapagliflozin acutely improves endothelial dysfunction, reduces aortic stiffness and renal resistive index in type 2 diabetic patients: a pilot study. Cardiovasc Diabetol, 16, 2017, 138.
    • (2017) Cardiovasc Diabetol , vol.16 , pp. 138
    • Solini, A.1    Giannini, L.2    Seghieri, M.3
  • 25
    • 84908555003 scopus 로고    scopus 로고
    • SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria
    • Yukihiro, C., Yoshishige, S., Soichi, S., et al. SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria. Biopharm Drug Dispos 35 (2014), 391–404.
    • (2014) Biopharm Drug Dispos , vol.35 , pp. 391-404
    • Yukihiro, C.1    Yoshishige, S.2    Soichi, S.3
  • 26
    • 84950282194 scopus 로고    scopus 로고
    • Uric acid in metabolic syndrome: from an innocent bystander to a central player
    • Kanbay, M., Jensen, T., Solak, Y., et al. Uric acid in metabolic syndrome: from an innocent bystander to a central player. Eur J Intern Med 29 (2016), 3–8.
    • (2016) Eur J Intern Med , vol.29 , pp. 3-8
    • Kanbay, M.1    Jensen, T.2    Solak, Y.3
  • 27
    • 84994236427 scopus 로고    scopus 로고
    • Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes
    • Daniele, G., Xiong, J., Solis-Herrera, C., et al. Dapagliflozin enhances fat oxidation and ketone production in patients with type 2 diabetes. Diabetes Care 39 (2016), 2036–2041.
    • (2016) Diabetes Care , vol.39 , pp. 2036-2041
    • Daniele, G.1    Xiong, J.2    Solis-Herrera, C.3
  • 28
    • 84975775560 scopus 로고    scopus 로고
    • The failing heart relies on ketone bodies as a fuel
    • Aubert, G., Martin, O.J., Horton, J.L., et al. The failing heart relies on ketone bodies as a fuel. Circulation 133 (2016), 698–705.
    • (2016) Circulation , vol.133 , pp. 698-705
    • Aubert, G.1    Martin, O.J.2    Horton, J.L.3
  • 29
    • 85021694438 scopus 로고    scopus 로고
    • Differential effects of dapagliflozin on cardiovascular risk factors at varying degrees of renal function
    • Petrykiv, S., Sjostrom, C.D., Greasley, P.J., Xu, J., Persson, F., Heerspink, H.J.L., Differential effects of dapagliflozin on cardiovascular risk factors at varying degrees of renal function. Clin J Am Soc Nephrol 12 (2017), 751–759.
    • (2017) Clin J Am Soc Nephrol , vol.12 , pp. 751-759
    • Petrykiv, S.1    Sjostrom, C.D.2    Greasley, P.J.3    Xu, J.4    Persson, F.5    Heerspink, H.J.L.6
  • 30
    • 84937635957 scopus 로고    scopus 로고
    • Antidiabetic agents: potential anti-inflammatory activity beyond glucose control
    • Scheen, A., Esser, N., Paquot, N., Antidiabetic agents: potential anti-inflammatory activity beyond glucose control. Diabetes Metab 41 (2015), 183–194.
    • (2015) Diabetes Metab , vol.41 , pp. 183-194
    • Scheen, A.1    Esser, N.2    Paquot, N.3
  • 31
    • 84995969879 scopus 로고    scopus 로고
    • Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome
    • Kusaka, H., Koibuchi, N., Hasegawa, Y., Ogawa, H., Kim-Mitsuyama, S., Empagliflozin lessened cardiac injury and reduced visceral adipocyte hypertrophy in prediabetic rats with metabolic syndrome. Cardiovasc Diabetol, 15, 2016, 157.
    • (2016) Cardiovasc Diabetol , vol.15 , pp. 157
    • Kusaka, H.1    Koibuchi, N.2    Hasegawa, Y.3    Ogawa, H.4    Kim-Mitsuyama, S.5
  • 32
    • 84945455839 scopus 로고    scopus 로고
    • Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes
    • Chilton, R., Tikkanen, I., Cannon, C.P., et al. Effects of empagliflozin on blood pressure and markers of arterial stiffness and vascular resistance in patients with type 2 diabetes. Diabetes Obes Metab 17 (2015), 1180–1193.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 1180-1193
    • Chilton, R.1    Tikkanen, I.2    Cannon, C.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.