Opinion of the Scientific Panel on additives and products or substances used in animal feed (FEEDAP) on the re-evaluation of efficacy and safety of the coccidiostat Monteban® G100 in accordance with article 9G of Council Directive 70/524/EEC

EFSA Journal

Volumn 2, Issue 7, 2004, Pages

[No Author Info available]

Author keywords

ADI; anticoccidial efficacy; coccidiostat; consumer safety; environmental safety; feed additive; ionophore; microbiological risks; Monteban; MRL; narasin; target animal safety; worker safety

Indexed keywords

EID: 85071620420     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2004.90     Document Type: Article

References (50)

1. Anadón, A. and Martinez-Larrañaga, M.R. 1990. Facteurs affectant la toxicité des ionophores anticoccidiens chez la volaille. Rev. Méd. Vét. 141 (1), 17–24.
2. Anadón, A. and Reeve-Johnson, L. 1999. Macrolide antibiotics, drug interactions and microsomal enzymes: implications for veterinary medicine. Res. Vet. Sci. 66 (3), 197–203.
3. Anonymous, WHO Global strategy for containment of antimicrobial resistance. 2001, WHO/CDS/CSR/DRS/2001.2
4. Brennan J. Bagg R, Barnum D, Wilson J and Dick P. 2001. Efficacy of narasin in the prevention of necrotic enteritis in broiler chickens. Avian Dis. 45, 210–214.
5. Brennan J, Skinner J, Barnum D and Wilson J. 2003. The efficacy of bacitracin methylene disalicylate when fed in combination with narasin in the management of necrotic enteritis in broiler chickens. Poultry Sci. 82: 360–363
6. Broz, J. and Frigg, M. 1987. Incompatibility between lasalocid and chloramphenicol in broiler chicks after a long-term simultaneous administration. Vet. Res. Commun. 11(2), 159–172.
7. Butaye, P, Devriese L.A. and Haesebrouck F. Incomplete cross resistance against ionophores in Enterococcus faecalus and Enterococcus faecium strains from pigs and poultry. Microbio. Drug Res., 6, 59–61, 2000.
8. Bywater B.J., Deluyker H., Deroover, E., De Jong, A., Marion, H., McConville, M., Rowan, T., Shuster, D., Thomas, V., Vallée, M., and Walters, J. 2003. European Antimicrobial Susceptibility surveillance in animals (EASSA) programme: results on antimicrobial susceptibility of enteric bacteria from pigs. J. vet. Pharmacol. Therap., 26 Supp 1, 165.
9. Chapman, H.D. and Hacker, A.B. 1994. Sensitivity of Field Isolates of Eimeria from Two Broiler Compexes to Anticoccidial Drugs in the Chicken. Poultry Sci. 73, 1404–1408.
10. Chapman HD. 1998. Evaluation of the efficacy of anticoccidial drugs against Eimeria species in the fowl. Int. J. Parasitol. 28 (7), 1141–1144.
11. Comben, N. 1984. Toxicity of the ionophores. Veterinary Rec. Feb 4; 114(5): 128.
12. DANMAP – Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark. 1997, 1998, 1999, 2000, 2001, 2002 www.dfvf.dk
13. Daugschies, A., Gässlein, U., and Rommel, M. 1998. Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials. Vet. Parasitol. 76, 163–171.
14. Elwinger K., Schneitz C., Berndtson E., Fossum O., Teglof B. and Engstom B. 1992. Factors affecting the incidence of necrotic enteritis, caecal carriage of Clostridium perfringens and birds performance in broiler chicks. Acta. Vet. Scand. 33, 369–378.
15. Elwinger K., Engström B., Fossum O., Hassan S. and Teglöf B. 1994. Effects of coccidiostatics on necrotic enteritis and performance in broiler chickens. Swedish J. Agric. Res. 24, 39–44.
16. Franklin, A., Acar, J, Anthony, F., Gupta, R., Nicholls, T., Tamura, Y., Thompson, S., Threlfall, E.J., Vose, D. van Vuuren, M., Wegener, H.C., White, D.G. and Costarrica, M.L. Antimicrobial resistance: harmonization of national antimicrobial resistance monitoring and surveillance programmes in animals and in animal-derived food. Rev. Sci. Tech. Off. Int. Epiz. 2001, 20, 859–870.
17. Frigg, M., Broz, J. and Weber, G. 1983. Compatibility studies of ionophore anticoccidials with various antibiotics and chemotherapeutics. Arch Geflügelk, 47, 213–220.
18. Goodyear KL 2002. DEFRA Antimicrobial Resistance Coordination Group. Veterinary surveillance for antimicrobial resistance. J Antimicrob Chemother. 50 (61), 2–4.
19. Guerra B., Junker E, Schroeter A, Malorny B, Lehmann S, Helmuth R. 2003. Phenotypic and genotypic characterization of antimicrobial resistance in German Escherichia coli isolates from cattle, swine and poultry. J Antimicrob Chemother. 52 (3), 489–492.
20. Guneratne, J.R.M., Gard, D.L. 1991. A Comparison of three continuous and four shuttle anticoccidial programs. Poultry Sci. 70, 1888–1894.
21. Hanrahan, L. A., Corrier, D. E. and Naqi, S. A., 1981. Monensin toxicosis in boiler chickens. Veterinary. Pathology 18, 665–671.
22. Laczay, P., Simon, F., Mora, Z. and Lehel, J. (1989). The compatibility of the new ionophore-coccidiostats with of chemotherapeutics in broilers. Dtsch Tierarztle Wochenschr. 96: 449–451
23. Laczay, P., Varga, I., Mora, Z., Lehel, J., Romvary, A., Semjen, G. and Fekete, J. 1994: Potentiation of ionophorous anticoccidials with dihydroquinolines: reduction of adverse interactions with antimicrobials. Int. J. Parasitol. 24 (3), 421–423
24. Larrey, D., Tinel, M. and Pessayre, D. 1983. Formation of inactive cytochrome P-450 Fe(II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Biochem. Pharmacol. 32 (9), 1487–1493
25. Lehel, J., Laczay, P., Mora, Z. and Semjen, G. 1995. Toxicological studies on potentiated ionophores in chickens. I: Compatibility study. Acta Vet. Hung. 43 (2–3), 335–345
26. Marounek M and Rada V. 1995. Susceptibility of poultry lactobacilli to ionophore antibiotics. J. Vet. Med. B. 42: 193–196
27. Meingassner, J.G., Schmook, F.P., Czok, R. and Mieth, H. (1979). Enhancement of the anticoccidial activity of polyether antibiotics in chickens by tiamulin. Poult. Sci. 58 (2), 308–313
28. Moreno, M.A., Domínguez L., Teshager T., Herrero, I.A. and Porrero, M.C. 2000. Antibiotic resistance monitoring: the Spanish programme. The VAV Network. Red de Vigilancia de Resistencias Antibioticas en Bacterias de Origen Veterinario. Int J Antimicrob Agents; 14: 285–90.
29. Noda, A. 1999. Chromosome aberration study of narasin by mammalian cell culture, Final Report provided to Eli Lilly Japan, Study Number 97–186 (T2NJA9820), Research Institute for Animal Science in Biochemistry and Toxicology, Kanagawa, Japan. Volume 18, Reference 14. Code NAR/602/1-29.
30. NORM-VET 2002. Consumption and antimicrobial agents and occurrence of antimicrobial resistance in Norway. www.zoonoses.no
31. Peek, H.W. and Landman, W.J.M. 2003. Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001. Avian Pathology, 27 (4), 391–401.
32. Peeters J.E., Derijcke J., Verlinden M., Wyffels R. 1994. Sensitivity of avian Eimeria spp. to seven chemical and five ionophore anticoccidials in five Belgian integrated broiler operations. Avian Dis., 38, 3, 483-493.
33. Rohrer, A.R., Furumoto, E.J., Wesley; R.D., Ikeme, A.I., Pratt, D.E. and Stadelman, W.J. 1984: Flavor Evaluation of Chicken Meat from Broilers Fed Narasin. Poultry Sci. 63, 269–273.
34. Salles MS, Lombardo de Barros CS, Barros SS. 1994. Ionophore antibiotic (narasin) poisoning in rabbits. Vet. Human Toxicol, 36, 437–444.
35. Sanders, P., Gicquel, M., Humbert, F., Perrin-Guyomard, A. and Salvat G. 2002. Plan de surveillance de la résistance aux antibiotiques chez les bactéries indicatrices isolées de la flore intestinale des porcs et de la volaille 1999–2001. Bull. Acad. Vet. De France; 155, 267–277
36. Salyi, G. Szabo E, Bago G, Banhidi G, Szilagyi M. 1988. Narasin poisoning in turkeys. Acta Vet Hung 36, 107–114.
37. SWARM 2002 Swedish Veterinary Antimicrobial Monitoring. www.sva.se
38. Sweeney, D.J., Kennington, A. and Donoho, A.L. 1996. Tissue residues and metabolism of narasin in chicken. J. Agr. Food Chem., 44, 2829–2834.
39. Szucs, G., Bajnogel, J., Varga, A., Mora, Z. and Laczay, P. 2000a. Studies on the toxic interaction between monensin and tiamulin in rats: toxicity and pathology. Acta Vet. Hung. 48 (2), 209–219.
40. Szucs, G., Laczay, P., Bajnogel, J. and Mora, Z. 2000b. Studies on the toxic interaction between monensin and tiamulin in rats: effects on P450 activities. Acta Vet. Hung. 48 (3), 361–368.
41. Umemura, T., Kawaminami, A., Goryo, M. and Itakura, C. 1985. Enhanced myotoxicity and involvement of both type I and II fibers in monsensin-tiamulin toxicosis in pigs. Vet. Pathol. 22 (4), 409–414.
42. VanVleet, J.F., Runnels, L.J., Cook, J.R. Jr. and Scheidt, A.B. 1987. Monensin toxicosis in swine: potentiation by tiamulin administration and ameliorative effect of treatment with selenium and/or vitamin E. Am. J. Vet. Res. 48 (10), 1530–1524.
43. Watkins, K.L., Bafundo, K.W. 1993. Effect of anticoccidial programs on broiler performance. J. Appl. Poultry Res. 2, 55–60.
44. Watkins, P.B., Wrighton, S.A., Schuetz, E.G., Maurel, P. and Guzelian P.S. 1986. Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome p-450p in rat hepatocytes in vivo and in primary monolayer culture. J. Bio. Chem. 261 (14), 6264–6271.
45. Watkins, K.L., Schryok, T.R., Dearth, R.N. and Saif, Y.M. 1997. In vitro antimicrobial susceptibility of Clostridium perfringens from commercial turkey and broiler chicken origin. Vet. Microbiol. 54, 195–200.
46. Weisman, Y., Herz, A., Yegana, Y., Egyed, M.N. and Shlosberg, A. 1983a. The effect of tiamulin administered by different routes and at different ages to turkeys receiving monensin in their feed. Vet. Res. Commun. 6 (3), 189–198.
47. Weisman, Y., Herz, A., Yegana, Y., Egyed, M.N. and Shlosberg, A. 1983b. Effect of tiamulin administered by various methods and dosages on turkeys at different ages. Avian Dis. 27 (1): 218–224.
48. Witkamp, R.F., Nijmeijer, S.M., Csikó, G. and van Miert, A.S. 1994. Tiamulin selectively inhibits oxidative hepatic steroid and drug metabolism in vitro in the pig. J. Vet. Pharmacol. Ther. 17 (4), 317–322
49. Witkamp, R.F., Nijmeijer, S.M., Monshouwer, M. and van Miert, A.S. 1995. The antibiotic tiamulin is a potent inducer and inhibitor of cytochrome P-450 3A via the formation of a stable metabolic intermediate complex. Studies in primary hepatocyte cultures and liver microsomes of the pig. Drug Metab. Dispos. 23 (5), 542–547.
50. Zhu G. and McDougald, L.R. 1992. Characterization In Vitro and In Vivo of Resistance to Ionophores in a Strain of Eimeria tenella. J. Parasitol. 78, 1067–1073.