Tissue Residues and Metabolism of Narasin in Chicken

Journal of Agricultural and Food Chemistry

Volumn 44, Issue 9, 1996, Pages 2829-2834

  Sweeney, Daniel J ^a   Kennington, Allison ^a   Donoho, Alvin L ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Mass spectrometry; Metabolites; Narasin; Residues

Indexed keywords

GALLUS GALLUS;

EID: 0542391344     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf950804b     Document Type: Article

References (12)

1. Berg, D. H.; Hamill, R. L. The isolation and characterization of narasin, a new polyether antibiotic. J. Antibiot. 1978, 1-6.
2. Brown, M. A.; Rajan, S. Maduramicin: rat metabolism of a highly potent polyether anticoccidial examined by carbon-13 NMR. J. Agric. Food Chem. 1986, 34, 470-472.
3. Catherman, D. R.; Szabo, J.; Batson, D. B.; Cantor, A. H.; Tucker, R. E.; Mitchell, G. E. Metabolism of narasin in chickens and Japanese quail. Poult. Sci. 1991, 70, 120-125.
4. Dimenna, G. P.; Lyon F. S.; Thompson F. M.; Creegan J. A.; Wright G. J. Effect of antibiotic combination, dosing period, dose vehicle, and assay method on salinomycin residue levels and their ionophoricity in chicken tissues. J. Agric. Food Chem. 1989, 37, 668-676.
5. Donoho, A. L. Biochemical studies on the fate of monensin in animals and in the environment. J. Anim. Sci. 1984, 58, 1528-1539.
6. Donoho, A. L.; Manthey, J.; Occolowitz, J.; and Zornes, L. Metabolism of monensin in the steer and rat. J. Agric. Food Chem. 1978, 26, 1090-1095
7. Dorman, D. E.; Paschal, J. W.; Nakatsukas, W. M.; Huckstep, L. L.; Neuss, N. Biosynthesis of narasin, a new polyether ionophore from fermentation of Streptomyces aureofaciens. Helv. Chim. Acta 1976, 59, 2625-2634.
8. Lynch, M. J.; Frame, G. M.; Ericson, J. F.; Illyes, E. F.; Nowakowski, M. A. Semduramicin in the chicken. In Xenobiotics and Food-Producing Animals; Hutson D. H., et al., Eds.; American Chemical Society: Washington DC, 1992; pp 49-68.
9. Manthey, J. A.; Goebel, B. S. Isolation and characterization of narasin metabolites derived from excreta of orally dosed chickens. Unpublished. Lilly Research Laboratories, 1982.
10. Occolowitz, J. L.; Berg, D. H.; Debono, M.; Hamill, R. L. The structure of narasin and a related ionophore. Biomed. Mass Spectrosc. 1976, 3, 272-277.
11. 14C-derived residues in turkey excreta. J. Agric. Food Chem. 1991, 39, 386-391.
12. Sweeney, D. J., Kennington, A.S. Narasin metabolite study with rat feces. Unpublished. Lilly Research Laboratories, 1994.