Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor

Veterinary Microbiology

Volumn 237, Issue , 2019, Pages

  Perera, Krishani Dinali ^a   Rathnayake, Athri ^b   Liu, Hongwei ^c   Pedersen, Niels C ^c   Groutas, William C ^b   Chang, Kyeong Ok ^a   Kim, Yunjeong ^a  

^a KANSAS STATE UNIVERSITY   (United States)

^b WICHITA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3C like protease; Antivirals; Feline coronavirus; Feline infectious peritonitis virus; Genetic barrier; Resistance

Indexed keywords

3C LIKE PROTEASE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME; VIRAL PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIVIRAL THERAPY; ARTICLE; CRYSTAL STRUCTURE; FELINE CORONAVIRUS; FELINE INFECTIOUS PERITONITIS; FELINE INFECTIOUS PERITONITIS VIRUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HYDROGEN BOND; IC50; MALE; NONHUMAN; SEQUENCE ALIGNMENT; VIRUS RESISTANCE; VIRUS STRAIN; ANIMAL; BINDING SITE; CASE REPORT; CAT; CAT DISEASE; CHEMISTRY; COMPLICATION; CORONAVIRIDAE INFECTION; ENZYMOLOGY; METABOLISM; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; VETERINARY MEDICINE; VIROLOGY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CAT DISEASES; CATS; CORONAVIRIDAE INFECTIONS; CORONAVIRUS, FELINE; FELINE INFECTIOUS PERITONITIS; MALE; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RNA, VIRAL; SEQUENCE ALIGNMENT; VIRAL PROTEINS;

EID: 85071399407     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2019.108398     Document Type: Article

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