Impact of G6PD status on red cell storage and transfusion outcomes

Blood Transfusion

Volumn 17, Issue 4, 2019, Pages 289-295

  Karafin, Matthew S ^a   Francis, Richard O ^b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b Department of Medicine   (United States)

Author keywords

Blood transfusion; Glucosephosphate dehydrogenase deficiency; Haemolysis; Metabolomics; Sickle cell

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; HUMAN; IN VITRO STUDY; IRRADIATION; METABOLOMICS; REVIEW; SICKLE CELL ANEMIA; ANIMAL; BLOOD DONOR; BLOOD STORAGE; CYTOLOGY; DONOR SELECTION; ERYTHROCYTE; HEMOLYSIS; METABOLISM; PROCEDURES; TREATMENT OUTCOME;

ANIMALS; BLOOD DONORS; BLOOD PRESERVATION; DONOR SELECTION; ERYTHROCYTE TRANSFUSION; ERYTHROCYTES; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HEMOLYSIS; HUMANS; TREATMENT OUTCOME;

EID: 85070579396     PISSN: 17232007     EISSN: 23852070     Source Type: Journal    
DOI: 10.2450/2019.0092-19     Document Type: Review

References (48)

1. Nkhoma ET, Poole C, Vannappagari V, et al. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis. Blood Cells Mol Dis 2009; 42: 267-78.
2. Minucci A, Moradkhani K, Hwang MJ, et al. Glucose-6-phosphate dehydrogenase (G6PD) mutations database: Review of the "old" and update of the new mutations. Blood Cells Mol Dis 2012; 48: 154-65.
3. Beutler E, Gaetani G, der Kaloustian V, et al. Glucose-6-phosphate dehydrogenase deficiency. WHO Working Group. Bull World Health Organ 1989; 67: 601-11.
4. Luzzatto L, Arese P. Favism and glucose-6-phosphate dehydrogenase deficiency. New Engl J Med 2018; 378: 60-71.
5. Kirkman HN, Galiano S, Gaetani GF. The function of catalasebound NADPH. J Biol Chem 1987; 262: 660-6.
6. McCurdy PR, Morse EE. Glucose-6-phosphate dehydrogenase deficiency and blood transfusion. Vox Sang 1975; 28: 230-7.
7. Mimouni F, Shohat S, Reisner SH. G6PD-deficient donor blood as a cause of hemolysis in two preterm infants. Isr J Med Sci 1986; 22: 120-2.
8. Sagiv E, Fasano RM, Luban NLC, et al. Glucose-6-phosphatedehydrogenase deficient red blood cell units are associated with decreased posttransfusion red blood cell survival in children with sickle cell disease. Am J Hematol 2018; 93: 630-4.
9. Samanta S, Kumar P, Kishore SS, et al. Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemia. Pediatrics 2009; 123: E96-100.
10. Shalev O, Bogomolski-Yahalom V, Sharon R. Hemolysis following transfusion of erythrocytes from a donor with G6PD deficiency and beta-thalassemia minor. Isr J Med Sci 1993; 29: 214-6.
11. Stainsby D, Dhingra N, James V, et al. Blood donor selection: Guidelines on assessing donor suitability for blood donation. Geneva: World Health Organization; 2012.
12. Marks PA, Johnson AB, Hirschberg E. Effect of Age on the enzyme activity in erythrocytes. Proc Natl Acad Sci U S A 1958; 44: 529-36.
13. Peters AL, van Bruggen R, de Korte D, et al. Glucose-6-phosphate dehydrogenase activity decreases during storage of leukoreduced red blood cells. Transfusion 2016; 56: 427-32.
14. Tzounakas VL, Kriebardis AG, Georgatzakou HT, et al. Glucose 6-phosphate dehydrogenase deficient subjects may be better "storers" than donors of red blood cells. Free Radic Biol Med 2016; 96: 152-65.
15. Leonart MS, Nascimento AJ, Nonoyama K, et al. Enzymes and membrane proteins of ADSOL-preserved red blood cells. Sao Paulo Med J 2000; 118: 41-5.
16. Nogueira D, Rocha S, Abreu E, et al. Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion. Transfus Med Hemother 2015; 42: 46-51.
17. Xiong Y, Xiong Y, Wang Y, et al. Inhibition of glutathione synthesis via decreased glucose metabolism in stored RBCs. Cell Physiol Biochem 2018; 51: 2172-84.
18. Francis RO, Jhang J, Hendrickson JE, et al. Frequency of glucose-6-phosphate dehydrogenase-deficient red blood cell units in a metropolitan transfusion service. Transfusion 2013; 53: 606-11.
19. Mourad N. Effect of prolonged storage on erythrocyte enzymes. Transfusion 1969; 9: 141-2.
20. Rocchigiani M, Pescaglini M, Sestini S, et al. Density increase and ageing of erythrocytes in stored blood. J Int Med Res 1989; 17: 461-6.
21. Noble NA, Tanaka KR, Myhre BA, Johnson DE. Red cell enzyme activity during blood storage and reactivation of phosphofructokinase. Am J Hematol 1982; 13: 1-8.
22. D'Alessandro A, Culp-Hill R, Reisz JA, et al. Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: Lessons from REDS-III-Omics. Transfusion 2019; 59: 89-100.
23. Timperio A, Marisole C, D'Alessandro A, Zolla L. Red blood cell lipidomics analysis through HPLC-ESI-qTOF: Application to red blood cell storage. JIOMICS 2013; 3: 11-24.
24. Lachant NA, Noble NA, Myrhe BA, Tanaka KR. Antioxidant metabolism during blood storage and its relationship to posttransfusion red cell survival. Am J Hematol 1984; 17: 237-49.
25. Messana I, Ferroni L, Misiti F, et al. Blood bank conditions and RBCs: The progressive loss of metabolic modulation. Transfusion 2000; 40: 353-60.
26. Reisz JA, Wither MJ, Dzieciatkowska M, et al. Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. Blood 2016; 128: E32-42.
27. Orlina AR, Josephson AM, McDonald BJ. The poststorage viability of glucose-6-phosphate dehydrogenase-deficient erythrocytes. J Lab Clin Med 1970; 75: 930-6.
28. Agarwal P, Ray VL, Choudhury N, et al. Effect of gamma irradiation on blood from glucose 6 phosphate dehydrogenase deficient blood donors. Hematology 2007; 12: 267-70.
29. Tzounakas VL, Kriebardis AG, Georgatzakou HT, et al. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Data Brief 2016; 8: 618-27.
30. Nantakomol D, Palasuwan A, Chaowanathikhom M, et al. Red cell and platelet-derived microparticles are increased in G6PD-deficient subjects. Eur J Haematol 2012; 89: 423-9.
31. Tzounakas VL, Gevi F, Georgatzakou HT, et al. Redox status, procoagulant activity, and metabolome of fresh frozen plasma in glucose 6-phosphate dehydrogenase deficiency. Frontiers Med 2018; 5: 16.
32. Dumaswala UJ, Wilson MJ, Wu YL, et al. Glutathione loading prevents free radical injury in red blood cells after storage. Free Rad Res 2000; 33: 517-29.
33. Reisz JA, Tzounakas VL, Nemkov T, et al. Metabolic linkage and correlations to storage capacity in erythrocytes from glucose 6-phosphate dehydrogenase-deficient donors. Frontiers Med 2017; 4: 248.
34. Tang HY, Ho HY, Wu PR, et al. Inability to maintain GSH pool in G6PD-deficient red cells causes futile AMPK activation and irreversible metabolic disturbance. Antioxid Redox Signal 2015; 22: 744-59.
35. Dumont LJ, AuBuchon JP. Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials. Transfusion 2008; 48: 1053-60.
36. Francis RO, Belpulsi D, Soffing M, et al. Glucose-6-phosphate dehydrogenase deficiency in blood donors is associated with decreased post-transfusion red cell recovery. Blood 2017; 130: 706.
37. Bahar B, Tormey CA. Prevention of transfusion-associated Graft-versus-Host Disease with blood product irradiation: The past, present, and future. Arch Pathol Lab Med 2018; 142: 662-7.
38. Westerman MP, Wald N, Diloy-Puray M. Irradiation shortens the survival time of red cells deficient in glucose-6-phosphate dehydrogenase. Radiat Res 1980; 81: 473-7.
39. Tizianello A, Pannacciulli I, Salvidio E, Gay A. Erythrocytic glucose-6-phosphate dehydrogenase deficiency as a problem in the selection of blood donors. Vox Sang 1963; 8: 47-50.
40. Saugstad OD. Oxidative stress in the newborn-a 30-year perspective. Biol Neonate 2005; 88: 228-36.
41. Olowe SA, Ransome-Kuti O. Exchange transfusion using G-6-PG deficient or Hgb-AS blood in icteric neonates. J Natl Med Assoc 1981; 73: 811-9.
42. Shalev O, Manny N, Sharon R. Posttransfusional hemolysis in recipients of glucose-6-phosphate dehydrogenase-deficient erythrocytes. Vox Sang 1993; 64: 94-8.
43. Huang CS, Sung YC, Huang MJ, et al. Content of reduced glutathione and consequences in recipients of glucose-6-phosphate dehydrogenase deficient red blood cells. Am J Hematol 1998; 57: 187-92.
44. Hermann PB, Pianovski MA, Henneberg R, et al. Erythrocyte oxidative stress markers in children with sickle cell disease. J Pediatr (Rio J) 2016; 92: 394-9.
45. Dumont LJ, Yoshida T, AuBuchon JP. Anaerobic storage of red blood cells in a novel additive solution improves in vivo recovery. Transfusion 2009; 49: 458-64.
46. Kratz A, Ferraro M, Sluss PM, Lewandrowski KB. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Laboratory reference values. New Engl J Med 2004; 351: 1548-63.
47. Shalev O, Eliakim R, Lugassy GZ, Menczel J. Hypoglycemiainduced hemolysis in glucose-6-phosphate dehydrogenase deficiency. Acta Haematol 1985; 74: 227-9.
48. Vanelli M, Lucentini L, Picco P, et al. Blood glucose normalization-induced haemolysis in three adolescents with type 1 diabetes mellitus at onset and unknown G-6-PD deficiency. J Pediatr Endocrinol Metab 1996; 9: 193-6.