Phase I/II Randomized Study of Proton Beam with Anti–Vascular Endothelial Growth Factor for Exudative Age-Related Macular Degeneration: One-Year Results

Ophthalmology Retina

Volumn 1, Issue 3, 2017, Pages 217-226

  Osmanovic, Senad ^a   Moisseiev, Elad ^a   Mishra, Kavita K ^b   Daftari, Inder ^b   Moshiri, Ala ^a   Morse, Lawrence ^a   Park, Susanna S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; RANIBIZUMAB;

AGE RELATED MACULAR DEGENERATION; AGED; ANGIOGRAPHY; BEST CORRECTED VISUAL ACUITY; CATARACT; CENTRAL RETINAL THICKNESS; CLINICAL EFFECTIVENESS; CONFERENCE PAPER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; MALE; OPHTHALMOSCOPE; OPHTHALMOSCOPY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTON THERAPY; RADIOTHERAPY DOSAGE; RANDOMIZED CONTROLLED TRIAL; RETINA ANGIOGRAPHY; RETINOPATHY; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; WET MACULAR DEGENERATION;

EID: 85070485654     PISSN: None     EISSN: 24686530     Source Type: Journal    
DOI: 10.1016/j.oret.2016.11.003     Document Type: Conference Paper

References (27)

1. Bressler, N.M., Age-related macular degeneration is the leading cause of blindness. JAMA 291 (2004), 1900–1901.
2. Wong, W.L., Su, X., Li, X., et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health 2 (2014), e106–e116.
3. Rosenfeld, P.J., Brown, D.M., Heier, J.S., et al., MARINA Study Group. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med 355 (2006), 1419–1431.
4. Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group, Martin, D.F., Maguire, M.G., Fine, S.L., et al. Ranibizumab and bevacizumab for treatment of neovascular age-related macular degeneration: two-year results. Ophthalmology 119 (2012), 1388–1398.
5. Chakravarthy, U., MacKenzie, G., External beam radiotherapy in exudative age-related macular degeneration: a pooled analysis of phase 1 data. Br J Radiol 73 (2000), 305–313.
6. Flaxel, C.J., Friedrichsen, E.J., Smith, J.O., et al. Proton beam irradiation of subfoveal choroidal neovascularisation in age-related macular degeneration. Eye (Lond) 14 (2000), 155–164.
7. Hess, C., Vuong, V., Hegyi, I., et al. Effect of VEGF receptor inhibitor PTK787/ZK222584 [correction of ZK222548] combined with ionizing radiation on endothelial cells and tumour growth. Br J Cancer 85 (2001), 2010–2016.
8. Jain, R.K., Tumor angiogenesis and accessibility: role of vascular endothelial growth factor. Semin Oncol 29 (2002), 3–9.
9. Avila, M.P., Farah, M.E., Santos, A., et al. Twelve-month short-term safety and visual-acuity results from a multicentre prospective study of epiretinal strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration. Br J Ophthalmol 93 (2009), 305–309.
10. Dugel, P.U., Bebchuk, J.D., Nau, J., et al. Epimacular brachytherapy for neovascular age-related macular degeneration: a randomized, controlled trial (CABERNET). Ophthalmology 120 (2013), 317–327.
11. Archambeau, J.O., Mao, X.W., Yonemoto, L.T., et al. What is the role of radiation in the treatment of subfoveal membranes: review of radiobiologic, pathologic, and other considerations to initiate a multimodality discussion. Int J Radiat Oncol Biol Phys 40 (1998), 1125–1136.
12. Yonemoto, L.T., Slater, J.D., Friedrichsen, E.J., et al. Phase I/II study of proton beam irradiation for the treatment of subfoveal choroidal neovascularization in age-related macular degeneration: treatment techniques and preliminary results. Int J Radiat Oncol Biol Phys 36 (1996), 867–871.
13. Dunavoelgyi, R., Dieckmann, K., Gleiss, A., et al. Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys 81 (2011), 199–205.
14. Zambarakji, H.J., Lane, A.M., Ezra, E., et al. Proton beam irradiation for neovascular age-related macular degeneration. Ophthalmology 113 (2006), 2012–2019.
15. Park, S.D., Phillips, I., Morse, L., Three year follow-up of a pilot study of ranibizumab combined with proton beam irradiation as treatment for exudative age-related macular degeneration. Retina 32 (2012), 956–966.
16. Goitein, M., Miller, T., Planning proton therapy of the eye. Med Phys 10 (1983), 275–283.
17. Park, S.S., Truong, S.N., Zawadzki, R.J., et al. High-resolution Fourier-domain optical coherence tomography of choroidal neovascular membranes associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 51 (2010), 4200–4206.
18. Trikha, R., Morse, L.S., Zawadzki, R.J., et al. Ten-year follow-up of eyes treated with stereotactic fractionated external beam radiation for neovascular age-related macular degeneration. Retina 31 (2011), 1303–1315.
19. Ciulla, T.A., Danis, R.P., Klein, S.B., et al. Proton therapy for exudative age-related macular degeneration: a randomized, sham-controlled clinical trial. Am J Ophthalmol 134 (2002), 905–906.
20. Parsons, J.T., Bova, F.J., Fitzgerald, C.R., et al. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys 30 (1994), 765–773.
21. Bianciotto, C., Shields, C.L., Pirondini, C., et al. Proliferative radiation retinopathy after plaque radiotherapy for uveal melanoma. Ophthalmology 117 (2010), 1005–1012.
22. Chen, L., Kim, I.K., Lane, A.M., et al. Proton beam irradiation for non-AMD CNV: 2-year results of a randomised clinical trial. Br J Ophthalmol 98 (2014), 1212–1217.
23. Zeisberg, A., Seibel, I., Cordini, D., et al. Long-term (4 years) results of choroidal hemangioma treated with proton beam irradiation. Graefes Arch Clin Exp Ophthalmol 252 (2014), 1165–1170.
24. Sarraf, D., Joseph, A., Rahimy, E., Retinal pigment epithelial tears in the era of intravitreal pharmacotherapy: risk factors, pathogenesis, prognosis and treatment (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc 112 (2014), 142–159.
25. Spaide, R.F., Guyer, D.R., McCormick, B., et al. External beam radiation therapy for choroidal neovascularization. Ophthalmology 105 (1998), 24–30.
26. Petrarca, R., Dugel, P.U., Nau, J., et al. Macular epiretinal brachytherapy in treated age-related macular degeneration (MERITAGE): month 12 optical coherence tomography and fluorescein angiography. Ophthalmology 120 (2013), 328–333.
27. Moshfeghi, D.M., Kaiser, P.K., Gertner, M., Stereotactic low-voltage x-ray irradiation for age-related macular degeneration. Br J Ophthalmol 95 (2011), 185–188.