Flavorant–Solvent Reaction Products and Menthol in JUUL E-Cigarettes and Aerosol

American Journal of Preventive Medicine

Volumn 57, Issue 3, 2019, Pages 425-427

  Erythropel, Hanno C ^a,b   Davis, Lucy M ^c   de Winter, Tamara M ^b,d   Jordt, Sven E ^b,e   Anastas, Paul T ^b,d   O'Malley, Stephanie S ^b   Krishnan Sarin, Suchitra ^b   Zimmerman, Julie B ^a,b,d  

^a Yale University   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE NUS COLLEGE   (Singapore)

^d Yale University   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVORING AGENT; GLYCEROL; MENTHOL; NICOTINE BENZOATE; NICOTINE DERIVATIVE; NITROGEN; PROPYLENE GLYCOL; SOLVENT; UNCLASSIFIED DRUG; VANILLIN; VEGETABLE GLYCERIN; ACETAL DERIVATIVE; ALDEHYDE;

AEROSOL; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETER); HUMAN; MASS FRAGMENTOGRAPHY; QUANTITATIVE ANALYSIS; VAPING; CHEMISTRY; ELECTRONIC CIGARETTE; FOOD AND DRUG ADMINISTRATION; TOXICITY; UNITED STATES;

ACETALS; AEROSOLS; ALDEHYDES; ELECTRONIC NICOTINE DELIVERY SYSTEMS; FLAVORING AGENTS; HUMANS; MENTHOL; SOLVENTS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 85069726908     PISSN: 07493797     EISSN: 18732607     Source Type: Journal    
DOI: 10.1016/j.amepre.2019.04.004     Document Type: Article

References (16)

1. Huang, J, Duan, Z, Kwok, J, et al. Vaping versus JUULing: how the extraordinary growth and marketing of JUUL transformed the U.S. retail e-cigarette market. Tob Control, 28(2), 2018, 146‒151 https://doi.org/10.1136/tobaccocontrol-2018-054382.
2. Willett, JG, Bennett, M, Hair, EC, et al. Recognition, use and perceptions of JUUL among youth and young adults. Tob Control, 28(1), 2019, 115‒116 https://doi.org/10.1136/tobaccocontrol-2018-054273.
3. HHS. E-cigarette use among youth and young adults: a report of the Surgeon General. Atlanta, GA: HHS, CDC, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016. https://ecigarettes.surgeongeneral.gov/documents/2016_sgr_full_report_non-508.pdf. Accessed April 2019.
4. Erythropel HC, Jabba SV, De Winter TM, et al. Formation of flavorant-propylene glycol adducts with novel toxicological properties in chemically unstable e-cigarette liquids. Nicotine Tob Res. In press. Online October 18, 2018. https://doi.org/10.1093/ntr/nty192.
5. Bautista, DM, Pellegrino, M, Tsunozaki, M, TRPA1: a gatekeeper for inflammation. Annu Rev Physiol, 75, 2013, 181‒200 https://doi.org/10.1146/annurev-physiol-030212-183811.
6. Sosnowski, TR, Odziomek, M, Particle size dynamics: toward a better understanding of electronic cigarette aerosol interactions with the respiratory system. Front Physiol, 9, 2018, 853 https://doi.org/10.3389/fphys.2018.00853.
7. Rosbrook, K, Erythropel, HC, DeWinter, TM, et al. The effect of sucralose on flavor sweetness in electronic cigarettes varies between delivery devices. PLoS One, 12(10), 2017, e0185334 https://doi.org/10.1371/journal.pone.0185334.
8. Ai, J, Taylor, KM, Lisko, JG, Tran, H, Watson, CH, Holman, MR, Menthol content in U.S. marketed cigarettes. Nicotine Tob Res, 18(7), 2016, 1575‒1580 https://doi.org/10.1093/ntr/ntv162.
9. Heck, JD., A review and assessment of menthol employed as a cigarette flavoring ingredient. Food Chem Toxicol, 48(suppl 2), 2010, S1‒S38 https://doi.org/10.1016/j.fct.2009.11.002.
10. Goniewicz ML, Boykan R, Messina CR, Eliscu A, Tolentino J. High exposure to nicotine among adolescents who use Juul and other vape pod systems (‘pods’). Tob Control. In press. Online September 7, 2018. https://doi.org/10.1136/tobaccocontrol-2018-054565.
11. Calafat, AM, Polzin, GM, Saylor, J, Richter, P, Ashley, DL, Watson, CH, Determination of tar, nicotine, and carbon monoxide yields in the mainstream smoke of selected international cigarettes. Tob Control, 13(1), 2004, 45‒51 https://doi.org/10.1136/tc.2003.003673.
12. Trushin N, Goel R, Reilly SM, Richie JP, Jr, Bitzer ZT. Free radical, carbonyl, and nicotine levels produced by Juul electronic cigarettes. Nicotine Tob Res. In press. Online October 20, 2018. https://doi.org/10.1093/ntr/nty221.
13. Occupational Alliance for Risk Science (OARS). Workplace environmental exposure levels (WEEL). www.tera.org/OARS/WEELs.pdf. Published 2014. Accessed April 12, 2019.
14. Ha, MA, Smith, GJ, Cichocki, JA, et al. Menthol attenuates respiratory irritation and elevates blood cotinine in cigarette smoke exposed mice. PLoS One, 10(2), 2015, e0117128 https://doi.org/10.1371/journal.pone.0117128.
15. Willis, DN, Liu, B, Ha, MA, Jordt, SE, Morris, JB, Menthol attenuates respiratory irritation responses to multiple cigarette smoke irritants. FASEB J, 25(12), 2011, 4434‒4444 https://doi.org/10.1096/fj.11-188383.
16. Gottlieb S, Abernethy A. FDA voices: understanding the health impact and dangers of smoke and ‘vapor’. Silver Spring, MD; U.S. Food and Drug Administration. https://www.fda.gov/news-events/fda-voices-perspectives-fda-experts/understanding-health-impact-and-dangers-smoke-and-vapor. Accessed April 2019.