Free Radical, Carbonyl, and Nicotine Levels Produced by Juul Electronic Cigarettes

Nicotine and Tobacco Research

Volumn 21, Issue 9, 2019, Pages 1274-1278

  Reilly, Samantha M ^a   Bitzer, Zachary T ^b   Goel, Reema ^a   Trushin, Neil ^a   Richie, John P ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAVORING AGENT; FREE RADICAL; NICOTINE; PROPYLENE GLYCOL;

DRUG EFFECT; ELECTRONIC CIGARETTE; HUMAN; OXIDATIVE STRESS; PHYSIOLOGY;

ELECTRONIC NICOTINE DELIVERY SYSTEMS; FLAVORING AGENTS; FREE RADICALS; HUMANS; NICOTINE; OXIDATIVE STRESS; PROPYLENE GLYCOL;

EID: 85060307793     PISSN: 14622203     EISSN: 1469994X     Source Type: Journal    
DOI: 10.1093/ntr/nty221     Document Type: Article

References (28)

1. Craver R. Juul exceeds 60 percent market share for e-cigs. Winston-Salem Journal. 20www.journalnow.com/business/juul-exceeds-percentmarket-share-for-e-cigs/article_1fd229f1-df7d-5436-Ac90-9263c418dc1c. html
2. Hafner J. Juuling is popular with teens, but doctor sees a ?good chance? that it leads to smoking. USA Today. 20www.usatoday.com/story/ money/nation-now/2017/10/31/juul-e-cigs-controversial-vaping-devicepopular-school-campuses/818325001/
3. Zernike K. ?I Can?t Stop?: schools struggle with vaping explosion. New York Times. 20www.nytimes.com/2018/04/02/health/vaping-ecigarettes-addiction-Teen.html
4. Willett JG, Bennett M, Hair EC, et al. Recognition, use and perceptions of JUUL among youth and young adults. Tob Control. 20doi:10.1136/ tobaccocontrol-2018-054273.
5. U.S Food and Drug Administration. Statement From FDA Commissioner Scott Gottlieb, M.D., on New Enforcement Actions and a Youth Tobacco Prevention Plan to Stop Youth Use of, and Access to, JUUL and Other E-Cigarettes. 20www.fda.gov/NewsEvents/Newsroom/ PressAnnouncements/ucm605432.htm. Accessed May 21, 2018.
6. Kirkham P, Rahman I. Oxidative stress in asthma and COPD: Antioxidants as a therapeutic strategy. Pharmacol Ther. 2006;111(2):476?494.
7. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010;49(11):1603?1616.
8. Bitzer ZT, Goel R, Reilly SM, et al. Effect of flavoring chemicals on free radical formation in electronic cigarette aerosols. Free Radic Biol Med. 2018;120:72?79.
9. Bitzer ZT, Goel R, Reilly SM, et al. Effects of solvent and temperature on free radical formation in electronic cigarette aerosols. Chem Res Toxicol. 2018;31(1):4?12.
10. Sleiman M, Logue JM, Montesinos VN, et al. Emissions from electronic cigarettes: key parameters affecting the release of harmful chemicals. Environ Sci Technol. 2016;50(17):9644?9651.
11. Wang P, Chen W, Liao J, et al. A device-independent evaluation of carbonyl emissions from heated electronic cigarette solvents. PLoS One. 2017;12(1):e0169811.
12. Farsalinos K, Poulas K, Voudris V. Changes in puffing topography and nicotine consumption depending on the power setting of electronic cigarettes. Nicotine Tob Res. 2018;20(8):993?997.
13. Juul Labs Inc. JUULpod Basics. 2018 https://support.juul.com/home/learn/ faqs/juulpod-basics Accessed May 22, 2018.
14. Pankow JF, Kim K, McWhirter KJ, et al. Benzene formation in electronic cigarettes. PLoS One. 2017;12(3):e0173055.
15. Etter JF, Zäther E, Svensson S. Analysis of refill liquids for electronic cigarettes. Addiction. 2013;108(9):1671?1679.
16. Goniewicz ML, Kuma T, Gawron M, Knysak J, Kosmider L. Nicotine levels in electronic cigarettes. Nicotine Tob Res. 2013;15(1):158?166.
17. Duell AK, Pankow JF, Peyton DH. Free-base nicotine determination in electronic cigarette liquids by 1H NMR spectroscopy. Chem Res Toxicol. 2018;31(6):431?434.
18. Risner CH, Martin P. Quantitation of formaldehyde, acetaldehyde, and acetone in sidestream cigarette smoke by high-performance liquid chromatography. J Chromatogr Sci. 1994;32(3):76?82.
19. CORESTA. Routine Analytical Machine for E-Cigarette Aerosol Generation and Collection?Definitions and Standard Conditions. 20www.coresta.org/routine-Analyticalmachine-e-cigarette-Aerosol-generation-and-collection-definitions-And-standard. Accessed August 15, 2018.
20. Goel R, Trushin N, Reilly SM, et al. A survey of nicotine yields in small cigar smoke: influence of cigar design and smoking regimens. Nicotine Tob Res. 2018;20(10):1250?1257.
21. Reilly SM, Goel R, Bitzer Z, et al. Effects of topography-related puff parameters on carbonyl delivery in mainstream cigarette smoke. Chem Res Toxicol. 2017;30(7):1463?1469.
22. Reilly SM, Goel R, Trushin N, et al. Brand variation in oxidant production in mainstream cigarette smoke: carbonyls and free radicals. Food Chem Toxicol. 2017;106(Pt A):147?154.
23. Goel R, Durand E, Trushin N, et al. Highly reactive free radicals in electronic cigarette aerosols. Chem Res Toxicol. 2015;28(9):1675?1677.
24. El-Hellani A, Salman R, El-Hage R, et al. Nicotine and carbonyl emissions from popular electronic cigarette products: correlation to liquid composition and design characteristics. Nicotine Tob Res. 2018;20(2):215?223.
25. Stiles MF, Campbell LR, Graff DW, Jones BA, Fant RV, Henningfield JE. Pharmacodynamic and pharmacokinetic assessment of electronic cigarettes, combustible cigarettes, and nicotine gum: implications for abuse liability. Psychopharmacology (Berl). 2017;234(17):2643?2655.
26. Goniewicz ML, Boykan R, Messina CR, Eliscu A, Tolentino J. High exposure to nicotine among adolescents who use Juul and other vape pod systems (?pods?). Tob Control. 20doi:10.1136/ tobaccocontrol-2018-054565.
27. Agnew-Heard KA, Lancaster VA, Bravo R, Watson C, Walters MJ, Holman MR. Multivariate statistical analysis of cigarette design feature influence on ISO TNCO yields. Chem Res Toxicol. 2016;29(6):1051?1063.
28. El-Hellani A, Salman R, El-Hage R, et al. Nicotine and carbonyl emissions from popular electronic cigarette products: correlation to liquid composition and design characteristics. Nicotine Tob Res. 2018;20(2):215?223