Impact of cultivation factors in vitro on the growth and the biosynthesis of steviol glycosides in Stevia rebaudiana cell cultures

Physiology and Molecular Biology of Plants

Volumn 25, Issue 4, 2019, Pages 1091-1096

  Bondarev, Nikolai ^a   Reshetnyak, Oxana ^b   Bondareva, Tatyana ^a   Il’in, Michael ^c   Nosov, Alexander ^b,d  

^a OREL STATE UNIVERSITY   (Russian Federation)

^b TIMIRYAZEV INSTITUTE OF PLANT PHYSIOLOGY   (Russian Federation)

^c A N NESMEYANOV INSTITUTE OF ORGANOELEMENT COMPOUNDS   (Russian Federation)

^d MOSCOW STATE UNIVERSITY   (Russian Federation)

Author keywords

Cell culture; Cultivation factors; In vitro; Stevia rebaudiana; Steviol glycosides

Indexed keywords

EID: 85068160014     PISSN: 09715894     EISSN: 09740430     Source Type: Journal    
DOI: 10.1007/s12298-019-00680-6     Document Type: Article

References (32)

1. Anufrieva EN (1997) The growth and photosynthetic characteristics of cell cultures of Serratula coronata and Ajuga reptans as ecdysteroid producers. Cand Sci (Biol). Dissertation, Timiryazev Institute of Plant Physiology, Moscow
2. Bondarev NI, Nosov AM (2004) Effect of light intensity on growth of Stevia rebaudiana cultures in vitro. In: Proceedings of the international conference «Topical issues of Botany and Plant Physiology», Ogarev Mordovia State University, Saransk, pp 40–41
3. Bondarev NI, Nosov AM, Kornienko AV (1997) The influence of several cultural factors on the growth and efficiency of stevia callus and suspension cultures. Biotechnol Russ 7–8:30–37
4. Bondarev NI, Nosov AM, Kornienko AV (1998) Effects of exogenous growth regulators on callusogenesis and growth of cultured cells of Stevia rebaudiana Bertoni. Russ J Plant Physiol 45:770–774
5. Bondarev NI, Reshetnyak OV, Nosov AM (2001) Peculiarities of diterpenoid steviol glycoside production in in vitro cultures of Stevia rebaudiana Bertoni. Plant Sci 161(1):155–163
6. Bondarev NI, Reshetnyak OV, Nosov AM (2003) Effects of nutrient medium composition on development of Stevia rebaudiana shoots cultivated in the roller bioreactor and their production of SGs. Plant Sci 165(4):845–850
7. Bondarev NI, Sukhanova MA, Reshetnyak OV, Nosov AM (2004) Steviol glycoside content in different organs of Stevia rebaudiana Bertoni and its dynamics during ontogenesis. Biol Plant 47:261–264
8. Bondarev NI, Reshetnyak OV, Nosov AM (2007) Growth features of various clones of Stevia rebaudiana Bertoni plants and accumulation of steviol glycosides in them in vivo and in vitro. Biotechnol Russ 1:22–28
9. Bondarev NI, Reshetnyak OV, Nosov AM (2008) The effects of photoperiod and light intensity on the shoot development and steviol glycosides synthesis by Stevia rebaudiana Bertoni in vitro. Izv Timiryazev Agric Acad 4:102–107
10. Bondarev NI, Reshetnyak OV, Nosov AM (2010) Effects of visible light spectral composition and UV-radiation on development of Stevia rebaudiana Bertoni plants in vitro and biosynthesis in them of steviol glycosides Scientific notes of Orel state university. Nat Tech Med Sci 4:55–62
11. Bondarev NI, Reshetnyak OV, Bondareva TA, Nosov AM (2012) Distribution and dynamic of diterpene glycosides contents in Stevia rebaudiana Bertoni intact plants. Biotechnol Russ 5:50–54
12. Bondarev NI, Kurilov DV, Bondareva TA, Stomakhin AA, Nosov AM (2014) Study of electron-dense thylakoids in chloroplasts of Stevia rebaudiana Bertoni in relation to the biosynthesis of diterpenoids. Biol Sect Cell Mol Biol 69(1):70–75
13. Brandle JE, Starratt AN, Gijzen M (1998) Stevia rebaudiana: its agricultural, biological and chemical properties. Can J Plant Sci 78:527–536
14. Butenko RG (1999) Biology of higher plant cells in vitro and biotechnologies on their bases. FBC-Press, Moscow
15. Chalapathi MK (1997) Natural non-calorie sweetener stevia (Stevia rebaudiana Bertoni). Future Crop For India Crop Res 14:347–350
16. Geuns JMC (2000) Safety of stevia and stevioside. Recent Res Dev Phytochem 4:75–88
17. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K (2004) Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 53(1):73–76
18. Hsieh M-H, Chan P, Sue Y-M, Liu J-C, Liang TH, Huang T-Y, Tomlinson B, Chow MSS, Kao P-F, Chen Y-J (2003) Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 25(11):2797–2808
19. Janarthanam B, Gopalakrishnan M, Sekar T (2010) Secondary metabolite production in callus cultures of Stevia rebaudiana Bertoni. Bangladesh J Sci Ind Res 45(3):243–248
20. Kinghorn AD, Soejarto DD (1986) Sweetening agents of plant origin. Crit Rev Plant Sci 4(2):79–120
21. Koppel LA, Butenko RG (1992) Development of tomato apical meristems in vitro under the influence of light with different spectral composition. Sov Plant Physiol 39(2):223–231
22. Ladygin V, Bondarev N, Semenova G, Smolov A, Reshetnyak O, Nosov A (2008) Chloroplast ultrastructure, photosynthetic apparatus activities and production of steviol glycosides in Stevia rebaudiana in vivo and in vitro. Biol Plant 52:9–16
23. Lyakhovkin AG, Long TD, Titov DA, Anh MP (1993) Cultivation and utilization of stevia (Stevia rebaudiana Bertoni). Agricultural publishing house, Hanoi
24. Mathur S, Shekhawat GS (2013) Establishment and characterization of Stevia rebaudiana (Bertoni) cell suspension culture: an in vitro approach production of stevioside. Acta Physiol Plant 35:931–939
25. Matsui M, Matsui K, Kawasaki Y, Oda Y, Noguchi T, Kitagawa Y, Sawada M, Hayashi M, Nohmi T, Yoshihira K, Ishidate M, Sofuni T (1996) Evaluation the genotoxicity of stevioside and steviol using six in vitro and one in vivo mutagenicity assays. Mutagenesis 11(6):573–579
26. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15(13):473–497
27. Nosov AM (1992) Steroid metabolism features in cultured Dioscorea deltoidea cells, as a basis for obtaining biotechnology of furostanol glycosides. Doctoral (Biol) Dissertation. Institute of the Applied Biochemistry and Machine-Building, Moscow
28. Nosov AM (2011) Assessment methods and characteristics of growth rate of the higher plants cells. In: Kuznetsov VIV, Kusnetsov VV, Romanov GA (eds) Molecular genetic and biochemical methods in modern plant biology. BINOM, Laboratory of Knowledge, Moscow, pp 386–402
29. Pausheva ZP (1988) Plant cytology practical training. Agropromizdat, Moscow
30. Rajasekaran T, Ramakrishna A, Udaya Sankar K, Giridhar P, Ravishankar GA (2008) Analysis of predominant steviosides in Stevia rebaudiana Bertoni by liquid chromatography/electrospray ionization-mass spectrometry. Food Biotechnol 22(2):179–188
31. Soejarto DD (2002) Ethnobotany of Stevia and Stevia rebaudiana. In: Kinghorn AD (ed) Stevia: the genus Stevia. Taylor & Francis, London, pp 40–67
32. Tateo F (1990) Technological and toxicological problems connected with the formulation of low-calorie foods. Riv Soc Ital Sci Aliment 19(1–2):13–23