Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

Nature Medicine

Volumn 25, Issue 5, 2019, Pages 730-733

  Dedrick, Rebekah M ^a   Guerrero Bustamante, Carlos A ^a   Garlena, Rebecca A ^a   Russell, Daniel A ^a   Ford, Katrina ^b   Harris, Kathryn ^b   Gilmour, Kimberly C ^b   Soothill, James ^b   Jacobs Sera, Deborah ^a   Schooley, Robert T ^c   Hatfull, Graham F ^a   Spencer, Helen ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIMYCOBACTERIAL AGENT; BACTERIOPHAGE DNA; BEDAQUILINE; CLOFAZIMINE; FLUORODEOXYGLUCOSE; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 6; IVACAFTOR PLUS LUMACAFTOR; MYCOPHENOLATE MOFETIL; RITUXIMAB; TUMOR NECROSIS FACTOR;

ABDOMINAL PAIN; ADD ON THERAPY; ADOLESCENT; AMINO ACID SUBSTITUTION; ANOREXIA; ANTIBIOTIC THERAPY; ANTIBODY RESPONSE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BODY WEIGHT GAIN; CASE REPORT; CLINICAL ARTICLE; CYSTIC FIBROSIS; CYTOKINE RESPONSE; DIARRHEA; DISSEMINATED DRUG RESISTANT MYCOBACTERIUM ABSCESSUS INFECTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ELECTROLYTE DISTURBANCE; ENGINEERED BACTERIOPHAGE; EPSTEIN BARR VIRUS INFECTION; FAILURE TO THRIVE; FEMALE; FORCED EXPIRATORY VOLUME; GASTROSTOMY; GENETIC ENGINEERING; GRANULOMATOSIS; HEPATOMEGALY; HOMOZYGOSITY; HOST RANGE; HUMAN; HYPERCAPNIA; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; LIVER FUNCTION; LIVER FUNCTION TEST; LUNG TRANSPLANTATION; MYCOBACTERIOSIS; MYCOBACTERIUM ABSCESSUS; MYCOBACTERIUM MASSILIENSE; MYCOBACTERIUM SMEGMATIS; NAUSEA; OSTEOPOROSIS; PALLIATIVE THERAPY; PANCREATIC INSUFFICIENCY; PEDIATRIC SURGERY; PHAGE THERAPY; POSITRON EMISSION TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; PSEUDOMONAS INFECTION; PULMONARY HYPERTENSION; REPRESSOR GENE; SKIN BIOPSY; SKIN DEFECT; SKIN NODULE; STOMACH FUNDOPLICATION; SURGICAL WOUND; THORAX RADIOGRAPHY; TOTAL PARENTERAL NUTRITION; WOUND CLOSURE; WOUND HEALING; X-RAY COMPUTED TOMOGRAPHY; ANTIBIOTIC RESISTANCE; ATYPICAL MYCOBACTERIOSIS; DRUG EFFECT; MICROBIOLOGY; PROCEDURES;

ADOLESCENT; CYSTIC FIBROSIS; DRUG RESISTANCE, BACTERIAL; FEMALE; GENETIC ENGINEERING; HUMANS; MYCOBACTERIUM ABSCESSUS; MYCOBACTERIUM INFECTIONS, NONTUBERCULOUS; PHAGE THERAPY;

EID: 85065592443     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/s41591-019-0437-z     Document Type: Article

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