Scientific Opinion on the substantiation of health claims related to lutein and maintenance of vision (ID 1603, 1604, 1931) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 8, Issue 2, 2010, Pages

[No Author Info available]

Author keywords

health claims; Lutein; vision

Indexed keywords

EID: 85062223705     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2010.1492     Document Type: Article

References (25)

1. Adackapara CA, Sunness JS, Dibernardo CW, Melia BM and Dagnelie G, 2008. Prevalence of cystoid macular edema and stability in oct retinal thickness in eyes with retinitis pigmentosa during a 48-week lutein trial. Retina, 28, 103–110.
2. Aleman TS, Duncan JL, Bieber ML, De Castro E, Marks DA, Gardner LM, Steinberg JD, Cideciyan AV, Maguire MG and Jacobson SG, 2001. Macular pigment and lutein supplementation in retinitis pigmentosa and Usher syndrome. Investigative Ophthalmology and Visual Science, 42, 1873–1881.
3. Bartlett H and Eperjesi F, 2003. Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic and Physiological Optics, 23, 383–399.
4. Bartlett HE and Eperjesi F, 2008. A randomised controlled trial investigating the effect of lutein and antioxidant dietary supplementation on visual function in healthy eyes. Clinical Nutrition, 27, 218–227.
5. Berendschot TT, Goldbohm RA, Klopping WA, Van de Kraats J, Van Norel J and Van Norren D, 2000. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Investigative Ophthalmology and Visual Science, 41, 3322–3326.
6. Bone RA, Landrum JT, Guerra LH and Ruiz CA, 2003. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. Journal of Nutrition, 133, 992–998.
7. Broekmans WM, Berendschot TT, Klopping-Ketelaars IA, De Vries AJ, Goldbohm RA, Tijburg LB, Kardinaal AF and Van Poppel G, 2002. Macular pigment density in relation to serum and adipose tissue concentrations of lutein and serum concentrations of zeaxanthin. American Journal of Clinical Nutrition, 76, 595–603.
8. Cangemi FE, 2007. TOZAL Study: an open case control study of an oral antioxidant and omega-3 supplement for dry AMD. BMC Ophthalmology, 7, 3.
9. Cardinault N, Gorrand JM, Tyssandier V, Grolier P, Rock E and Borel P, 2003. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. Experimental Gerontology, 38, 573–582.
10. Davies NP and Morland AB, 2004. Macular pigments: their characteristics and putative role. Progress in Retinal and Eye Research, 23, 533–559.
11. Duncan JL, Aleman TS, Gardner LM, De Castro E, Marks DA, Emmons JM, Bieber ML, Steinberg JD, Bennett J, Stone EM, MacDonald IM, Cideciyan AV, Maguire MG and Jacobson SG, 2002. Macular pigment and lutein supplementation in choroideremia. Experimental Eye Research, 74, 371–381.
12. Franciose JL, Askew EW, Lang JC and Bernstein PS, 2006. Serum and macular responses to antioxidant supplementation versus a carotenoid-rich dietary intervention in the elderly. Current Topics in Nutraceutical Research, 4, 69.
13. Hammond BR, Jr., Johnson EJ, Russell RM, Krinsky NI, Yeum KJ, Edwards RB and Snodderly DM, 1997. Dietary modification of human macular pigment density. Investigative Ophthalmology and Visual Science, 38, 1795–1801.
14. Johnson EJ, Chung HY, Caldarella SM and Snodderly DM, 2008. The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation. American Journal of Clinical Nutrition, 87, 1521–1529.
15. Johnson EJ, Hammond BR, Yeum KJ, Qin J, Wang XD, Castaneda C, Snodderly DM and Russell RM, 2000. Relation among serum and tissue concentrations of lutein and zeaxanthin and macular pigment density. American Journal of Clinical Nutrition, 71, 1555–1562.
16. Koh HH, Murray IJ, Nolan D, Carden D, Feather J and Beatty S, 2004. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. Experimental Eye Research, 79, 21–27.
17. Kopsell DA, Lefsrud MG, Kopsell DE, Wenzel AJ, Gerweck C and Curran-Celentano J, 2006. Spinach cultigen variation for tissue carotenoid concentrations influences human serum carotenoid levels and macular pigment optical density following a 12-week dietary intervention. Journal of Agricultural and Food Chemistry, 54, 7998–8005.
18. Kvansakul J, Rodriguez-Carmona M, Edgar DF, Barker FM, Kopcke W, Schalch W and Barbur JL, 2006. Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance. Ophthalmic and Physiological Optics, 26, 362–371.
19. Landrum JT, Bone RA, Joa H, Kilburn MD, Moore LL and Sprague KE, 1997. A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Experimental Eye Research, 65, 57–62.
20. Morganti P, Fabrizi G and Bruno C, 2004. Protective effects of oral antioxidants on skin and eye function. SKINmed, 3, 310–316.
21. Muth ER, Laurent JM and Jasper P, 2001. The Effect of Bilberry Nutritional Supplementation on Night Visual Acuity and Contrast Sensitivity. Alternative Medicine Review, 5, 164–173.
22. Olmedilla B, Granado F, Blanco I and Vaquero M, 2003. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind,* placebo-controlled pilot study. Nutrition, 19, 21–24.
23. Olmedilla B, Granado F, Blanco I, Vaquero M and Cajigal C, 2001. Lutein in patients with cataracts and age-related macular degeneration: a long-term supplementation study. Journal of the Science of Food and Agriculture, 81, 904–909.
24. Schalch W, Cohn W, Barker FM, Kopcke W, Mellerio J, Bird AC, Robson AG, Fitzke FF and Van Kuijk FJ, 2007. Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin-the LUXEA (LUtein Xanthophyll Eye Accumulation) study. Archives of Biochemistry and Biophysics, 458, 128–135.
25. Schweitzer D, Lang GE, Beuermann B, Remsch H, Hammer M, Thamm E, Spraul CW and Lang GK, 2002. Objective determination of optical density of xanthophyll after supplementation of lutein. Ophthalmologe, 99, 270–275.