Combining a fusion inhibitory peptide targeting the mers-cov s2 protein hr1 domain and a neutralizing antibody specific for the s1 protein receptor-binding domain (Rbd) showed potent synergism against pseudotyped mers-cov with or without mutations in rbd

Viruses

Volumn 11, Issue 1, 2019, Pages

  Wang, Cong ^a   Hua, Chen ^a   Xia, Shuai ^a   Li, Weihua ^a   Lu, Lu ^a   Jiang, Shibo ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Combination; MERS CoV; Mutation; Neutralizing antibody; Peptide; RBD

Indexed keywords

FUSION PROTEIN; HR2P M2 PEPTIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY M336; NEUTRALIZING ANTIBODY; S1 PROTEIN; S2 PROTEIN; UNCLASSIFIED DRUG; VIRAL PROTEIN; CORONAVIRUS SPIKE GLYCOPROTEIN; PEPTIDE; PROTEIN BINDING; VIRUS ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL FUSION; CONTROLLED STUDY; DRUG POTENTIATION; FEMALE; GENE MUTATION; IC50; MIDDLE EAST RESPIRATORY SYNDROME; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MOUSE; NONHUMAN; PROTEIN DOMAIN; RECEPTOR BINDING; VIRUS CELL INTERACTION; VIRUS INHIBITION; ANIMAL; BAGG ALBINO MOUSE; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; MUTATION; VIRUS ENTRY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; DRUG SYNERGISM; FEMALE; HEK293 CELLS; HUMANS; MICE; MICE, INBRED BALB C; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN DOMAINS; SPIKE GLYCOPROTEIN, CORONAVIRUS; VIRUS INTERNALIZATION;

EID: 85059795428     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v11010031     Document Type: Article

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