Serum beta carotene and overall and cause-specific mortality: A prospective cohort study

Circulation Research

Volumn 123, Issue 12, 2018, Pages 1339-1349

  Huang, Jiaqi ^a   Weinstein, Stephanie J ^a   Yu, Kai ^a   Männistö, Satu ^b   Albanes, Demetrius ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

beta carotene; cardiovascular diseases; epidemiology; mortality; multivariate analysis; primary prevention

Indexed keywords

BETA CAROTENE;

ACCIDENT; ADULT; AGE; ALCOHOL CONSUMPTION; ALL CAUSE MORTALITY; ARTICLE; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; FOLLOW UP; FOOD INTAKE; FRUIT; HEART DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INJURY; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASM; MIDDLE AGED; MORTALITY RISK; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT DISEASE; RISK FACTOR; SEROLOGY; SMOKING; SUPPLEMENTATION; VEGETABLE; VITAMIN BLOOD LEVEL; AGED; BLOOD; FINLAND; MORTALITY; NEOPLASM;

AGED; BETA CAROTENE; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; FINLAND; HUMANS; MALE; MIDDLE AGED; MORTALITY; NEOPLASMS; RESPIRATORY TRACT DISEASES; WOUNDS AND INJURIES;

EID: 85058878215     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.118.313409     Document Type: Article

References (39)

1. Stahl W, Sies H. Bioactivity and protective effects of natural carotenoids. Biochim Biophys Acta. 2005;1740:101-107. doi: 10.1016/j.bbadis.2004.12.006
2. Bendich A. From 1989 to 2001: what have we learned about the "biological actions of beta-carotene"? J Nutr. 2004;134:225S-230S.
3. Erlinger TP, Guallar E, Miller ER III, Stolzenberg-Solomon R, Appel LJ. Relationship between systemic markers of inflammation and serum beta-carotene levels. Arch Intern Med. 2001;161:1903-1908.
4. Higuchi K, Saito I, Maruyama K, Eguchi E, Mori H, Tanno S, Sakurai S, Kishida T, Nishida W, Osawa H, Tanigawa T. Associations of serum β-carotene and retinol concentrations with insulin resistance: the Toon Health Study. Nutrition. 2015;31:975-980. doi: 10.1016/j.nut.2015.02.015
5. Zhao LG, Zhang QL, Zheng JL, Li HL, Zhang W, Tang WG, Xiang YB. Dietary, circulating beta-carotene and risk of all-cause mortality: a meta-analysis from prospective studies. Sci Rep. 2016;6:26983. doi: 10.1038/srep26983
6. Goyal A, Terry MB, Siegel AB. Serum antioxidant nutrients, vitamin A, and mortality in U.S. Adults. Cancer Epidemiol Biomarkers Prev. 2013;22:2202-2211. doi: 10.1158/1055-9965.EPI-13-0381
7. Hashim D, Gaughan D, Boffetta P, Lucchini RG. Baseline serum β- carotene concentration and mortality among long-term asbestos-exposed insulators. Cancer Epidemiol Biomarkers Prev. 2015;24:555-560. doi: 10.1158/1055-9965.EPI-14-0952
8. Bates CJ, Hamer M, Mishra GD. Redox-modulatory vitamins and minerals that prospectively predict mortality in older British people: the National Diet and Nutrition Survey of people aged 65 years and over. Br J Nutr. 2011;105:123-132. doi: 10.1017/S0007114510003053
9. Kilander L, Berglund L, Boberg M, Vessby B, Lithell H. Education, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men. Int J Epidemiol. 2001;30:1119-1126.
10. Karppi J, Laukkanen JA, Mäkikallio TH, Ronkainen K, Kurl S. Low β- carotene concentrations increase the risk of cardiovascular disease mortality among Finnish men with risk factors. Nutr Metab Cardiovasc Dis. 2012;22:921-928. doi: 10.1016/j.numecd.2012.01.008
11. Ito Y, Suzuki K, Ishii J, Hishida H, Tamakoshi A, Hamajima N, Aoki K. A population-based follow-up study on mortality from cancer or cardiovascular disease and serum carotenoids, retinol and tocopherols in Japanese inhabitants. Asian Pac J Cancer Prev. 2006;7:533-546.
12. Buijsse B, Feskens EJ, Kwape L, Kok FJ, Kromhout D. Both alphaand beta-carotene, but not tocopherols and vitamin C, are inversely related to 15-year cardiovascular mortality in Dutch elderly men. J Nutr. 2008;138:344-350. doi: 10.1093/jn/138.2.344
13. Ito Y, Kurata M, Suzuki K, Hamajima N, Hishida H, Aoki K. Cardiovascular disease mortality and serum carotenoid levels: a Japanese population-based follow-up study. J Epidemiol. 2006;16:154-160.
14. Fletcher AE, Breeze E, Shetty PS. Antioxidant vitamins and mortality in older persons: findings from the nutrition add-on study to the Medical Research Council Trial of Assessment and Management of Older People in the Community. Am J Clin Nutr. 2003;78:999-1010. doi: 10.1093/ajcn/78.5.999
15. Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330:1029-1035. doi: 10.1056/NEJM199404143301501
16. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334:1150-1155. doi: 10.1056/NEJM199605023341802
17. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, LaMotte F, Gaziano JM, Ridker PM, Willett W, Peto R. Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med. 1996;334:1145-1149. doi: 10.1056/NEJM199605023341801
18. Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst. 1999;91:2102-2106.
19. The ATBC Cancer Prevention Study Group. The alpha-tocopherol, beta- carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. Ann Epidemiol. 1994;4:1-10. doi: 10.1016/1047-2797(94)90036-1
20. Milne DB, Botnen J. Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography. Clin Chem. 1986;32:874-876.
21. Aune D, Giovannucci E, Boffetta P, Fadnes LT, Keum N, Norat T, Greenwood DC, Riboli E, Vatten LJ, Tonstad S. Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortalitya systematic review and dose-response meta-analysis of prospective studies. Int J Epidemiol. 2017;46:1029-1056. doi: 10.1093/ije/dyw319
22. Carter P, Gray LJ, Troughton J, Khunti K, Davies MJ. Fruit and vegetable intake and incidence of type 2 diabetes mellitus: systematic review and meta-analysis. BMJ. 2010;341:c4229.
23. Pryor WA, Stahl W, Rock CL. Beta carotene: from biochemistry to clinical trials. Nutr Rev. 2000;58:39-53.
24. Young AJ, Lowe GM. Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys. 2001;385:20-27. doi: 10.1006/abbi.2000.2149
25. Rodriguez H, Cutler RG. Critical Reviews of Oxidative Stress and Aging Advances in Basic Science, Diagnostics and Intervention. Singapore: World Scientific Publishing Company; 2003.
26. Rodriguez-Concepcion M, Avalos J, Bonet ML, Boronat A, Gomez-Gomez L, Hornero-Mendez D, Limon MC, Meléndez-Martínez AJ, Olmedilla-Alonso B, Palou A, Ribot J, Rodrigo MJ, Zacarias L, Zhu C. A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. Prog Lipid Res. 2018;70:62-93. doi: 10.1016/j.plipres.2018.04.004
27. Al-Delaimy WK, Slimani N, Ferrari P, et al. Plasma carotenoids as biomarkers of intake of fruits and vegetables: ecological-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Clin Nutr. 2005;59:1397-1408. doi: 10.1038/sj.ejcn.1602253
28. Lampe JW. Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr. 1999;70:475S-490S. doi: 10.1093/ajcn/70.3.475s
29. Venkatasamy VV, Pericherla S, Manthuruthil S, Mishra S, Hanno R. Effect of physical activity on insulin resistance, inflammation and oxidative stress in diabetes mellitus. J Clin Diagn Res. 2013;7:1764-1766. doi: 10.7860/JCDR/2013/6518.3306
30. D'Ambrosio DN, Clugston RD, Blaner WS. Vitamin A metabolism: an update. Nutrients. 2011;3:63-103. doi: 10.3390/nu3010063
31. Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, Hu FB. Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies. BMJ. 2014;349:g4490.
32. Diaz MN, Frei B, Vita JA, Keaney JF Jr. Antioxidants and atherosclerotic heart disease. N Engl J Med. 1997;337:408-416. doi: 10.1056/NEJM199708073370607
33. Asplund K. Antioxidant vitamins in the prevention of cardiovascular disease: a systematic review. J Intern Med. 2002;251:372-392.
34. Shete V, Quadro L. Mammalian metabolism of β-carotene: gaps in knowledge. Nutrients. 2013;5:4849-4868. doi: 10.3390/nu5124849
35. Carroll YL, Corridan BM, Morrissey PA. Lipoprotein carotenoid profiles and the susceptibility of low density lipoprotein to oxidative modification in healthy elderly volunteers. Eur J Clin Nutr. 2000;54:500-507.
36. Arnlöv J, Zethelius B, Risérus U, Basu S, Berne C, Vessby B, Alfthan G, Helmersson J; Uppsala Longitudinal Study of Adult Men Study. Serum and dietary beta-carotene and alpha-tocopherol and incidence of type 2 diabetes mellitus in a community-based study of Swedish men: report from the Uppsala Longitudinal Study of Adult Men (ULSAM) study. Diabetologia. 2009;52:97-105. doi: 10.1007/s00125-008-1189-3
37. Grievink L, de Waart FG, Schouten EG, Kok FJ. Serum carotenoids, alpha-tocopherol, and lung function among Dutch elderly. Am J Respir Crit Care Med. 2000;161:790-795. doi: 10.1164/ajrccm.161.3.9904040
38. Kaluza J, Larsson SC, Orsini N, Linden A, Wolk A. Fruit and vegetable consumption and risk of COPD: a prospective cohort study of men. Thorax. 2017;72:500-509. doi: 10.1136/thoraxjnl-2015-207851
39. Li Y, Zhang J. Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide. Nutr Neurosci. 2007;10:51-58. doi: 10.1080/10284150701250747