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Volumn 46, Issue 1, 2019, Pages 19-27

Challenges in Advancing Necrotizing Enterocolitis Research

Author keywords

Clinical trials; Necrotizing enterocolitis; Preclinical research

Indexed keywords

PROBIOTIC AGENT; BIOLOGICAL MARKER;

EID: 85058172454     PISSN: 00955108     EISSN: 15579840     Source Type: Journal    
DOI: 10.1016/j.clp.2018.10.002     Document Type: Review
Times cited : (10)

References (45)
  • 1
    • 85015220773 scopus 로고    scopus 로고
    • Development of a gestational age-specific case definition for neonatal necrotizing enterocolitis
    • Battersby, C., Longford, N., Costeloe, K., et al., for the UK Neonatal Collaborative Necrotising Enterocolitis Study Group. Development of a gestational age-specific case definition for neonatal necrotizing enterocolitis. JAMA Pediatr 171 (2017), 256–263.
    • (2017) JAMA Pediatr , vol.171 , pp. 256-263
    • Battersby, C.1    Longford, N.2    Costeloe, K.3
  • 2
    • 35648934513 scopus 로고    scopus 로고
    • Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell's criteria?
    • Gordon, P.V., Swanson, J.R., Attridge, J.T., et al. Emerging trends in acquired neonatal intestinal disease: is it time to abandon Bell's criteria?. J Perinatol 27 (2007), 661–671.
    • (2007) J Perinatol , vol.27 , pp. 661-671
    • Gordon, P.V.1    Swanson, J.R.2    Attridge, J.T.3
  • 3
    • 85006827026 scopus 로고    scopus 로고
    • A critical question for NEC researchers: can we create a consensus definition of NEC that facilitates research progress?
    • Gordon, P.V., Swanson, J.R., MacQueen, B.C., et al. A critical question for NEC researchers: can we create a consensus definition of NEC that facilitates research progress?. Semin Perinatol 41 (2017), 7–14.
    • (2017) Semin Perinatol , vol.41 , pp. 7-14
    • Gordon, P.V.1    Swanson, J.R.2    MacQueen, B.C.3
  • 4
    • 0036894839 scopus 로고    scopus 로고
    • Surgical decision making in necrotizing enterocolitis and focal intestinal perforation: predictive value of radiologic findings
    • Tam, A.L., Camberos, A., Applebaum, H., Surgical decision making in necrotizing enterocolitis and focal intestinal perforation: predictive value of radiologic findings. J Pediatr Surg 37 (2002), 1688–1691.
    • (2002) J Pediatr Surg , vol.37 , pp. 1688-1691
    • Tam, A.L.1    Camberos, A.2    Applebaum, H.3
  • 5
    • 0032695750 scopus 로고    scopus 로고
    • Observer variability in interpretation of abdominal radiographs of infants with suspected necrotizing enterocolitis
    • Rehan, V.K., Seshia, M.M., Johnston, B., et al. Observer variability in interpretation of abdominal radiographs of infants with suspected necrotizing enterocolitis. Clin Pediatr (Phila) 38 (1999), 637–643.
    • (1999) Clin Pediatr (Phila) , vol.38 , pp. 637-643
    • Rehan, V.K.1    Seshia, M.M.2    Johnston, B.3
  • 6
    • 0018960062 scopus 로고
    • Interobserver variability in the radiographic diagnosis of necrotizing enterocolitis
    • Mata, A.G., Rosengart, R.M., Interobserver variability in the radiographic diagnosis of necrotizing enterocolitis. Pediatrics 66 (1980), 68–71.
    • (1980) Pediatrics , vol.66 , pp. 68-71
    • Mata, A.G.1    Rosengart, R.M.2
  • 7
    • 85012307908 scopus 로고    scopus 로고
    • Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study
    • Battersby, C., Longford, N., Mandalia, S., et al., UK Neonatal Collaborative Necrotising Enterocolitis (UKNC-NEC) Study Group. Incidence and enteral feed antecedents of severe neonatal necrotising enterocolitis across neonatal networks in England, 2012-13: a whole-population surveillance study. Lancet Gastroenterol Hepatol 2 (2017), 43–51.
    • (2017) Lancet Gastroenterol Hepatol , vol.2 , pp. 43-51
    • Battersby, C.1    Longford, N.2    Mandalia, S.3
  • 8
    • 0023316523 scopus 로고
    • Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness
    • Kliegman, R.M., Walsh, M.C., Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness. Curr Probl Pediatr 17 (1987), 213–288.
    • (1987) Curr Probl Pediatr , vol.17 , pp. 213-288
    • Kliegman, R.M.1    Walsh, M.C.2
  • 9
    • 0017917048 scopus 로고
    • Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging
    • Bell, M.J., Ternberg, J.L., Feigin, R.D., et al. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 187 (1978), 1–7.
    • (1978) Ann Surg , vol.187 , pp. 1-7
    • Bell, M.J.1    Ternberg, J.L.2    Feigin, R.D.3
  • 10
    • 85042946925 scopus 로고    scopus 로고
    • Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review
    • Battersby, C., Santhalingam, T., Costeloe, K., et al. Incidence of neonatal necrotising enterocolitis in high-income countries: a systematic review. Arch Dis Child Fetal Neonatal Ed 103 (2018), F182–F189.
    • (2018) Arch Dis Child Fetal Neonatal Ed , vol.103 , pp. F182-F189
    • Battersby, C.1    Santhalingam, T.2    Costeloe, K.3
  • 12
    • 0035219874 scopus 로고    scopus 로고
    • A National short-term follow-up study of extremely low birth weight infants born in finland in 1996–1997
    • Tommiska, V., Heinonen, K., Ikonen, S., et al. A National short-term follow-up study of extremely low birth weight infants born in finland in 1996–1997. Pediatrics, 107, 2001, e2.
    • (2001) Pediatrics , vol.107 , pp. e2
    • Tommiska, V.1    Heinonen, K.2    Ikonen, S.3
  • 13
    • 84875282408 scopus 로고    scopus 로고
    • Nosocomial infections in very low birthweight infants in Germany: current data from the National Surveillance System NEO-KISS
    • Leistner, R., Piening, B., Gastmeier, P., et al. Nosocomial infections in very low birthweight infants in Germany: current data from the National Surveillance System NEO-KISS. Klin Padiatr 225 (2013), 75–80.
    • (2013) Klin Padiatr , vol.225 , pp. 75-80
    • Leistner, R.1    Piening, B.2    Gastmeier, P.3
  • 14
    • 84882271842 scopus 로고    scopus 로고
    • Epidemiology and trends of necrotizing enterocolitis in Sweden: 1987-2009
    • Ahle, M., Drott, P., Andersson, R.E., Epidemiology and trends of necrotizing enterocolitis in Sweden: 1987-2009. Pediatrics 132 (2013), e443–e451.
    • (2013) Pediatrics , vol.132 , pp. e443-e451
    • Ahle, M.1    Drott, P.2    Andersson, R.E.3
  • 15
    • 84925024062 scopus 로고    scopus 로고
    • Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis
    • Kastenberg, Z.J., Lee, H.C., Profit, J., et al. Effect of deregionalized care on mortality in very low-birth-weight infants with necrotizing enterocolitis. JAMA Pediatr 169 (2015), 26–32.
    • (2015) JAMA Pediatr , vol.169 , pp. 26-32
    • Kastenberg, Z.J.1    Lee, H.C.2    Profit, J.3
  • 16
    • 66649093820 scopus 로고    scopus 로고
    • Mortality of necrotizing enterocolitis expressed by birth weight categories
    • Fitzgibbons, S.C., Ching, Y., Yu, D., et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg 44 (2009), 1072–1075.
    • (2009) J Pediatr Surg , vol.44 , pp. 1072-1075
    • Fitzgibbons, S.C.1    Ching, Y.2    Yu, D.3
  • 17
    • 84952881786 scopus 로고    scopus 로고
    • Necrotizing enterocolitis among very-low-birth-weight infants in Korea
    • Youn, Y.A., Kim, E.-K., Kim, S.Y., Necrotizing enterocolitis among very-low-birth-weight infants in Korea. J Korean Med Sci 30:Suppl 1 (2015), S75–S80.
    • (2015) J Korean Med Sci , vol.30 , pp. S75-S80
    • Youn, Y.A.1    Kim, E.-K.2    Kim, S.Y.3
  • 18
    • 84899082323 scopus 로고    scopus 로고
    • Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009
    • Wojkowska-Mach, J., Rozanska, A., Borszewska-Kornacka, M., et al. Necrotising enterocolitis in preterm infants: epidemiology and antibiotic consumption in the Polish neonatology network neonatal intensive care units in 2009. PLoS One, 9, 2014, e92865.
    • (2014) PLoS One , vol.9 , pp. e92865
    • Wojkowska-Mach, J.1    Rozanska, A.2    Borszewska-Kornacka, M.3
  • 19
    • 33744537563 scopus 로고    scopus 로고
    • Impact of gestational age on the clinical presentation and surgical outcome of necrotizing enterocolitis
    • Sharma, R., Hudak, M.L., Tepas, J.J. III, et al. Impact of gestational age on the clinical presentation and surgical outcome of necrotizing enterocolitis. J Perinatol 26 (2006), 342–347.
    • (2006) J Perinatol , vol.26 , pp. 342-347
    • Sharma, R.1    Hudak, M.L.2    Tepas, J.J.3
  • 20
    • 84927770048 scopus 로고    scopus 로고
    • Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota
    • Niemarkt, H.J., de Meij, T.G., van de Velde, M.E., et al. Necrotizing enterocolitis: a clinical review on diagnostic biomarkers and the role of the intestinal microbiota. Inflamm Bowel Dis 21 (2015), 436–444.
    • (2015) Inflamm Bowel Dis , vol.21 , pp. 436-444
    • Niemarkt, H.J.1    de Meij, T.G.2    van de Velde, M.E.3
  • 21
    • 84891662696 scopus 로고    scopus 로고
    • Biomarkers of necrotising enterocolitis
    • Ng, P.C., Biomarkers of necrotising enterocolitis. Semin Fetal Neonatal Med 19 (2014), 33–38.
    • (2014) Semin Fetal Neonatal Med , vol.19 , pp. 33-38
    • Ng, P.C.1
  • 22
    • 77953024950 scopus 로고    scopus 로고
    • Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis
    • Thuijls, G., Derikx, J.P.M., van Wijck, K., et al. Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann Surg 251 (2010), 1174–1180.
    • (2010) Ann Surg , vol.251 , pp. 1174-1180
    • Thuijls, G.1    Derikx, J.P.M.2    van Wijck, K.3
  • 23
    • 84906628519 scopus 로고    scopus 로고
    • Necrotizing enterocolitis: the mystery goes on
    • Neu, J., Necrotizing enterocolitis: the mystery goes on. Neonatology 106 (2014), 289–295.
    • (2014) Neonatology , vol.106 , pp. 289-295
    • Neu, J.1
  • 24
    • 85008190850 scopus 로고    scopus 로고
    • Pathogenesis of NEC: impact of an altered intestinal microbiome
    • Neu, J., Pammi, M., Pathogenesis of NEC: impact of an altered intestinal microbiome. Semin Perinatol 41 (2017), 29–35.
    • (2017) Semin Perinatol , vol.41 , pp. 29-35
    • Neu, J.1    Pammi, M.2
  • 25
    • 85008210242 scopus 로고    scopus 로고
    • Pathogenesis of NEC: role of the innate and adaptive immune response
    • Denning, T.L., Bhatia, A.M., Kane, A.F., et al. Pathogenesis of NEC: role of the innate and adaptive immune response. Semin Perinatol 41 (2017), 15–28.
    • (2017) Semin Perinatol , vol.41 , pp. 15-28
    • Denning, T.L.1    Bhatia, A.M.2    Kane, A.F.3
  • 26
    • 84941702065 scopus 로고    scopus 로고
    • Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012
    • Stoll, B.J., Hansen, N.I., Bell, E.F., et al. Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993-2012. JAMA 314 (2015), 1039–1051.
    • (2015) JAMA , vol.314 , pp. 1039-1051
    • Stoll, B.J.1    Hansen, N.I.2    Bell, E.F.3
  • 27
    • 84863021827 scopus 로고    scopus 로고
    • Incidence and timing of presentation of necrotizing enterocolitis in preterm infants
    • Yee, W.H., Soraisham, A.S., Shah, V.S., et al. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics 129 (2012), e298–e304.
    • (2012) Pediatrics , vol.129 , pp. e298-e304
    • Yee, W.H.1    Soraisham, A.S.2    Shah, V.S.3
  • 28
    • 84867162005 scopus 로고    scopus 로고
    • Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan
    • Isayama, T., Lee, S.K., Mori, R., et al. Comparison of mortality and morbidity of very low birth weight infants between Canada and Japan. Pediatrics 130 (2012), e957–e965.
    • (2012) Pediatrics , vol.130 , pp. e957-e965
    • Isayama, T.1    Lee, S.K.2    Mori, R.3
  • 29
    • 84973131236 scopus 로고    scopus 로고
    • Thirteen-year mortality and morbidity in preterm infants in Switzerland
    • Chen, F., Bajwa, N.M., Rimensberger, P.C., et al., Swiss Neonatal Network. Thirteen-year mortality and morbidity in preterm infants in Switzerland. Arch Dis Child Fetal Neonatal Ed 101 (2016), F377–F383.
    • (2016) Arch Dis Child Fetal Neonatal Ed , vol.101 , pp. F377-F383
    • Chen, F.1    Bajwa, N.M.2    Rimensberger, P.C.3
  • 30
    • 84940731146 scopus 로고    scopus 로고
    • Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada
    • Hossain, S., Shah, P.S., Ye, X.Y., et al. Outcome comparison of very preterm infants cared for in the neonatal intensive care units in Australia and New Zealand and in Canada. J Paediatr Child Health 51 (2015), 881–888.
    • (2015) J Paediatr Child Health , vol.51 , pp. 881-888
    • Hossain, S.1    Shah, P.S.2    Ye, X.Y.3
  • 31
    • 84943359335 scopus 로고    scopus 로고
    • Adverse impact of maternal cigarette smoking on preterm infants: a population-based cohort study
    • Isayama, T., Shah, P.S., Ye, X.Y., et al. Adverse impact of maternal cigarette smoking on preterm infants: a population-based cohort study. Am J Perinatol 32 (2015), 1105–1111.
    • (2015) Am J Perinatol , vol.32 , pp. 1105-1111
    • Isayama, T.1    Shah, P.S.2    Ye, X.Y.3
  • 32
    • 56049101409 scopus 로고    scopus 로고
    • Necrotising enterocolitis in very low birth weight infants in Italy: incidence and non-nutritional risk factors
    • Gagliardi, L., Bellu, R., Cardilli, V., et al. Necrotising enterocolitis in very low birth weight infants in Italy: incidence and non-nutritional risk factors. J Pediatr Gastroenterol Nutr 47 (2008), 206–210.
    • (2008) J Pediatr Gastroenterol Nutr , vol.47 , pp. 206-210
    • Gagliardi, L.1    Bellu, R.2    Cardilli, V.3
  • 33
    • 85011024435 scopus 로고    scopus 로고
    • A systematic review of administrative and clinical databases of infants admitted to neonatal units
    • Statnikov, Y., Ibrahim, B., Modi, N., A systematic review of administrative and clinical databases of infants admitted to neonatal units. Arch Dis Child Fetal Neonatal Ed 102 (2017), F270–F276.
    • (2017) Arch Dis Child Fetal Neonatal Ed , vol.102 , pp. F270-F276
    • Statnikov, Y.1    Ibrahim, B.2    Modi, N.3
  • 34
    • 84890700637 scopus 로고    scopus 로고
    • Probiotic effects on late-onset sepsis in very preterm infants: a randomized controlled trial
    • Jacobs, S.E., Tobin, J.M., Opie, G.F., et al., ProPrems Study Group. Probiotic effects on late-onset sepsis in very preterm infants: a randomized controlled trial. Pediatrics 132 (2013), 1055–1062.
    • (2013) Pediatrics , vol.132 , pp. 1055-1062
    • Jacobs, S.E.1    Tobin, J.M.2    Opie, G.F.3
  • 35
    • 84957845119 scopus 로고    scopus 로고
    • Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial
    • Costeloe, K., Hardy, P., Juszczak, E., et al., Probiotics in Preterm Infants Study Collaborative Group. Bifidobacterium breve BBG-001 in very preterm infants: a randomised controlled phase 3 trial. Lancet 387 (2016), 649–660.
    • (2016) Lancet , vol.387 , pp. 649-660
    • Costeloe, K.1    Hardy, P.2    Juszczak, E.3
  • 37
    • 85058174548 scopus 로고    scopus 로고
    • European medicines Agency 2007 The European paediatric initiative: History of the Paediatric Regulation. Available at: Accessed April 6.
    • European medicines Agency 2007 The European paediatric initiative: History of the Paediatric Regulation. Available at: http://www.ema.europa.eu/docs/en_GB/document_library/Other/2009/09/WC500003693.pdf. Accessed April 6, 2018.
    • (2018)
  • 38
    • 85058157836 scopus 로고    scopus 로고
    • Department of Health and Human Services Food and Drug Administration 2016 Best Pharmaceuticals for Children Act and Pediatric Research Equity Act Status Report to Congress. Available at: Accessed April 6.
    • Department of Health and Human Services Food and Drug Administration 2016 Best Pharmaceuticals for Children Act and Pediatric Research Equity Act Status Report to Congress. Available at: https://www.fda.gov/downloads/scienceresearch/specialtopics/pediatrictherapeuticsresearch/ucm509815.pdf. Accessed April 6, 2018.
    • (2018)
  • 39
    • 85033341934 scopus 로고    scopus 로고
    • Implementing and disseminating a core outcome set for neonatal medicine
    • Webbe, J., Brunton, G., Ali, S., et al. Implementing and disseminating a core outcome set for neonatal medicine. BMJ Paediatr Open, 1, 2017, e000048.
    • (2017) BMJ Paediatr Open , vol.1 , pp. e000048
    • Webbe, J.1    Brunton, G.2    Ali, S.3
  • 40
    • 85027853809 scopus 로고    scopus 로고
    • Core outcome sets in women's and newborn health: a systematic review
    • Duffy, J., Rolph, R., Gale, C., et al., International Collaboration to Harmonise Outcomes in Pre-eclampsia (iHOPE). Core outcome sets in women's and newborn health: a systematic review. BJOG 124 (2017), 1481–1489.
    • (2017) BJOG , vol.124 , pp. 1481-1489
    • Duffy, J.1    Rolph, R.2    Gale, C.3
  • 41
    • 84886247817 scopus 로고    scopus 로고
    • StaR Child Health: improving global standards for child health research
    • Offringa, M., Needham, A.C., Chan, W.W., StaR Child Health Group. StaR Child Health: improving global standards for child health research. Early Hum Dev 89 (2013), 861–864.
    • (2013) Early Hum Dev , vol.89 , pp. 861-864
    • Offringa, M.1    Needham, A.C.2    Chan, W.W.3
  • 42
    • 84934753682 scopus 로고    scopus 로고
    • Clinician enteral feeding preferences for very preterm babies in the UK
    • Mills, L., Modi, N., Clinician enteral feeding preferences for very preterm babies in the UK. Arch Dis Child Fetal Neonatal Ed 100 (2015), F372–F373.
    • (2015) Arch Dis Child Fetal Neonatal Ed , vol.100 , pp. F372-F373
    • Mills, L.1    Modi, N.2
  • 43
    • 84987910519 scopus 로고    scopus 로고
    • WHEAT trial development group Research ethics committee decision-making in relation to an efficient neonatal trial
    • Gale, C., Hyde, M.J., Modi, N., WHEAT trial development group Research ethics committee decision-making in relation to an efficient neonatal trial. Arch Dis Child Fetal Neonatal Ed 102 (2017), F291–F298.
    • (2017) Arch Dis Child Fetal Neonatal Ed , vol.102 , pp. F291-F298
    • Gale, C.1    Hyde, M.J.2    Modi, N.3
  • 44
    • 84958811508 scopus 로고    scopus 로고
    • WHEAT trial development group Neonatal randomised point-of-care trials are feasible and acceptable in the UK: results from two national surveys
    • Gale, C., Modi, N., WHEAT trial development group Neonatal randomised point-of-care trials are feasible and acceptable in the UK: results from two national surveys. Arch Dis Child Fetal Neonatal Ed 101 (2016), F86–F87.
    • (2016) Arch Dis Child Fetal Neonatal Ed , vol.101 , pp. F86-F87
    • Gale, C.1    Modi, N.2
  • 45
    • 85058147259 scopus 로고    scopus 로고
    • International Neonatal Consortium. Available at: Accessed April 6.
    • International Neonatal Consortium. Available at: https://c-path.org/programs/inc/. Accessed April 6, 2018.
    • (2018)


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