Haloperidol and ziprasidone for treatment of delirium in critical illness

New England Journal of Medicine

Volumn 379, Issue 26, 2018, Pages 2506-2516

  Girard, T D ^a   Exline, M C ^b   Carson, S S ^d   Hough, C L ^g   Rock, P ^h   Gong, M N ⁱ   Douglas, I S ^j   Malhotra, A ^k   Owens, R L ^k   Feinstein, D J ^f   Khan, B ^l   Pisani, M A ^m   Hyzy, R C ⁿ   Schmidt, G A ^o   Schweickert, W D ^p   Hite, R D ^c   Bowton, D L ^e   Masica, A L ^q   Thompson, J L ^r,w   Chandrasekhar, R ^r,s,w   Pun, B T ^r   Strength, C ^r,s,u   Boehm, L M ^r,z   Jackson, J C ^r,s,u,w,ab   Pandharipande, P P ^r,x,aa   Brummel, N E ^r,s,t,u   Hughes, C G ^r,x,aa   Patel, M B ^r,y,ac   Stollings, J L ^r,w   Bernard, G R ^r   Dittus, R S ^r,s,v,ad   Ely, E W ^r,s,t,u,ad   more..

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e WAKE FOREST BAPTIST HEALTH   (United States)

^f Cone Health System ^*  (United States)

^g UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

ⁱ MONTEFIORE MEDICAL CENTER   (United States)

^j DENVER HEALTH MEDICAL CENTER   (United States)

^k UNIVERSITY OF CALIFORNIA   (United States)

^l INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁿ UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^o UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^p UNIVERSITY OF PENNSYLVANIA   (United States)

^q SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^r VANDERBILT UNIVERSITY   (United States)

^s Center for Health Services Research   (United States)

^t Center for Quality Aging   (United States)

^u Division of Allergy   (United States)

^v Division of General Internal Medicine and Public Health   (United States)

^w Department of Biostatistics ^*  (United States)

^x Division of Anesthesiology Critical Care Medicine   (United States)

^y Department of Surgery   (United States)

^z VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aa Anesthesia Service   (United States)

^ab Research Service   (United States)

^ac Surgical Service VA   (United States)

^ad VETERANS AFFAIRS MEDICAL CENTER   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

HALOPERIDOL; PLACEBO; ZIPRASIDONE; DOPAMINE RECEPTOR BLOCKING AGENT; NEUROLEPTIC AGENT; PIPERAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ACUTE RESPIRATORY FAILURE; ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; COMA; CONTROLLED STUDY; CRITICAL ILLNESS; DELIRIUM; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG EXPOSURE; DRUG SAFETY; DRUG USE; DRUG WITHDRAWAL; DYSTONIA; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HOSPITAL DISCHARGE; HUMAN; INFORMED CONSENT; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; NEUROLEPTIC MALIGNANT SYNDROME; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; QT PROLONGATION; RANDOMIZED CONTROLLED TRIAL; SEDATION; SHOCK; TORSADE DES POINTES; CLINICAL TRIAL; COMPARATIVE STUDY; KAPLAN MEIER METHOD; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PSYCHOLOGY; RESPIRATORY FAILURE; TREATMENT FAILURE;

AGED; ANTIPSYCHOTIC AGENTS; CRITICAL ILLNESS; DELIRIUM; DOPAMINE ANTAGONISTS; DOUBLE-BLIND METHOD; FEMALE; HALOPERIDOL; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; PIPERAZINES; RESPIRATORY INSUFFICIENCY; SHOCK; THIAZOLES; TREATMENT FAILURE;

EID: 85057418814     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1808217     Document Type: Article

References (42)

1. Devlin JW, Skrobik Y, Gélinas C, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med 2018; 46(9): e825-e873.
2. Girard TD, Thompson JL, Pandharipande PP, et al. Clinical phenotypes of delirium during critical illness and severity of subsequent long-Term cognitive impairment: A prospective cohort study. Lancet Respir Med 2018; 6: 213-22.
3. Ely EW, Shintani A, Truman B, et al. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291: 1753-62.
4. Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009; 180: 1092-7.
5. Klein Klouwenberg PM, Zaal IJ, Spitoni C, et al. The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ 2014; 349: g6652.
6. Ely EW, Gautam S, Margolin R, et al. The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001; 27: 1892-900.
7. Shehabi Y, Riker RR, Bokesch PM, Wisemandle W, Shintani A, Ely EW. Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med 2010; 38: 2311-8.
8. Vasilevskis EE, Chandrasekhar R, Holtze CH, et al. The cost of ICU delirium and coma in the intensive care unit patient. Med Care 2018; 56: 890-7.
9. Pandharipande PP, Girard TD, Jackson JC, et al. Long-Term cognitive impairment after critical illness. N Engl J Med 2013; 369: 1306-16.
10. Saczynski JS, Marcantonio ER, Quach L, et al. Cognitive trajectories after postoperative delirium. N Engl J Med 2012; 367: 30-9.
11. Wolters AE, van Dijk D, Pasma W, et al. Long-Term outcome of delirium during intensive care unit stay in survivors of critical illness: A prospective cohort study. Crit Care 2014; 18: R125.
12. Dubois MJ, Bergeron N, Dumont M, Dial S, Skrobik Y. Delirium in an intensive care unit: A study of risk factors. Intensive Care Med 2001; 27: 1297-304.
13. Brummel NE, Girard TD, Ely EW, et al. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: The Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med 2014; 40: 370-9.
14. Ely EW, Stephens RK, Jackson JC, et al. Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: A survey of 912 healthcare professionals. Crit Care Med 2004; 32: 106-12.
15. Patel RP, Gambrell M, Speroff T, et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med 2009; 37: 825-32.
16. Morandi A, Piva S, Ely EW, et al. Worldwide survey of the "Assessing pain, Both spontaneous awakening and breathing trials, Choice of drugs, Delirium monitoring/management, Early exercise/mobility, and Family empowerment" (ABCDEF) bundle. Crit Care Med 2017; 45(11): e1111-e1122.
17. Mac Sweeney R, Barber V, Page V, et al. A national survey of the management of delirium in UK intensive care units. QJM 2010; 103: 243-51.
18. Girard TD, Pandharipande PP, Carson SS, et al. Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: The MIND randomized, placebocontrolled trial. Crit Care Med 2010; 38: 428-37.
19. Page VJ, Ely EW, Gates S, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): A randomised, double-blind, placebo-controlled trial. Lancet Respir Med 2013; 1: 515-23.
20. Devlin JW, Roberts RJ, Fong JJ, et al. Efficacy and safety of quetiapine in critically ill patients with delirium: A prospective, multicenter, randomized, doubleblind, placebo-controlled pilot study. Crit Care Med 2010; 38: 419-27.
21. Burry L, Mehta S, Perreault MM, et al. Antipsychotics for treatment of delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev 2018; 6: CD005594.
22. Jorm AF. A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): development and cross-validation. Psychol Med 1994; 24: 145-53.
23. Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001; 286: 2703-10.
24. Ely EW, Margolin R, Francis J, et al. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29: 1370-9.
25. Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166: 1338-44.
26. Ely EW, Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 2003; 289: 2983-91.
27. Peterson JF, Pun BT, Dittus RS, et al. Delirium and its motoric subtypes: A study of 614 critically ill patients. J Am Geriatr Soc 2006; 54: 479-84.
28. Simpson GM, Angus JW. A rating scale for extrapyramidal side effects. Acta Psychiatr Scand Suppl 1970; 212: 11-9.
29. Girard TD, Kress JP, Fuchs BD, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): A randomised controlled trial. Lancet 2008; 371: 126-34.
30. Ely EW. The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families. Crit Care Med 2017; 45: 321-30.
31. Balas MC, Burke WJ, Gannon D, et al. Implementing the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle into everyday care: opportunities, challenges, and lessons learned for implementing the ICU Pain, Agitation, and Delirium Guidelines. Crit Care Med 2013; 41: Suppl 1: S116-S127.
32. Barnes-Daly MA, Phillips G, Ely EW. Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6, 064 patients. Crit Care Med 2017; 45: 171-8.
33. Pun BT, Balas MC, Barnes-Daly MA, et al. Caring for critically ill patients with the ABCDEF bundle: results of the ICU Liberation Collaborative in over 15, 000 adults. Crit Care Med 2018 October 19 (Epub ahead of print).
34. R Core Team. R: A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing, 2018.
35. Dudley DL, Rowlett DB, Loebel PJ. Emergency use of intravenous haloperidol. Gen Hosp Psychiatry 1979; 1: 240-6.
36. Settle EC Jr, Ayd FJ Jr. Haloperidol: A quarter century of experience. J Clin Psychiatry 1983; 44: 440-8.
37. Tesar GE, Stern TA. Evaluation and treatment of agitation in the intensive care unit. J Intensive Care Med 1986; 1: 137-48.
38. Tesar GE, Murray GB, Cassem NH. Use of high-dose intravenous haloperidol in the treatment of agitated cardiac patients. J Clin Psychopharmacol 1985; 5: 344-7.
39. Riker RR, Fraser GL, Cox PM. Continuous infusion of haloperidol controls agitation in critically ill patients. Crit Care Med 1994; 22: 433-40.
40. Shehabi Y, Bellomo R, Kadiman S, et al. Sedation intensity in the first 48 hours of mechanical ventilation and 180-day mortality: A multinational prospective longitudinal cohort study. Crit Care Med 2018; 46: 850-9.
41. Woodward ND, Purdon SE, Meltzer HY, Zald DH. A meta-Analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects. Schizophr Res 2007; 89: 211-24.
42. Ray WA, Chung CP, Murray KT, Hall K, Stein CM. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009; 360: 225-35.